Solid pseudopapillary neoplasia of the pancreas: a review

Abstract

SUMMARY OBJECTIVES To review the literature and the diagnosis of conventional histopathological routine and immunohistochemistry of the cases diagnosed with Solid Pseudopapillary Neoplasm of the Pancreas (SPNP). METHODS The review of the literature was done using the Pubmed and solid Google-Scholar databases, through the historical, clinical aspects and diagnostic methods of SPNP. The review of SPNP cases diagnosed in the University Hospital Clementino Fraga Filho was carried out from 1977 to 2018. RESULTS Intratumoral phenotypic heterogeneity of SPNP was evidenced in the cases studied, taking into account macroscopic, microscopic, and immunohistochemical patterns. CONCLUSIONS The results show the importance of the examination of several fragments obtained from different regions of the neoplasia since not all of them present the same molecular alterations.

Solid bifocal pseudopapillary neoplasm of the pancreas: A case report

“…As a result, 90% of SPNPs have an abnormal pattern of nuclear marking of the protein β-catenin, whereas in a healthy pancreas, the marking is on the membrane. B-catenin interacts with E-cadherin, so the deregulation of the former interferes with the expression of the latter and, consequently, no membrane expression of E-cadherin is observed in most SPNP [ 14 ].…”

Large-duct pattern invasive adenocarcinoma of the pancreas–a variant mimicking pancreatic cystic neoplasms: A minireview

“…These types have unique paths during development and progression to invasive tumors[ 25 ], and specific genetic alterations observed in IPMNs may be responsible for tumor phenotypes and ultimately influence the patients’ outcome[ 26 , 27 ]. In most cases, other pancreatic lesions with cystic features, such as solid cystic neoplasm (SCN)[ 28 , 29 ], mucinous cystic neoplasm (MCN)[ 30 ], and solid pseudopapillary neoplasm (SPN)[ 28 ], can be easily distinguished from classic PDA[ 31 ]; however, atypical imaging findings of patients occasionally impair proper diagnosis. Knowledge and use of relevant genetic alterations unique to these cystic neoplasms may aid patients and physicians in making appropriate decisions.…”