Laboratory predictors of survival in ovarian cancer

Jammal, Millena Prata; Martins-Filho, Agrimaldo; Bandeira, Guilherme Henrique; Murta, Beatriz Martins Tavares; Murta, Eddie Fernando Cândido; Nomelini, Rosekeila Simões

doi:10.1590/1806-9282.66.1.61

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…However, as ovarian torsion is an acute inflammatory condition, markers such as WBC, Creactive protein (CRP), and D-dimer may increase in response to inflammation (15). An experimental study found that D-dimer levels were elevated in cases of ovarian torsion (16). CRP, an acute-phase reactant that rises in inflammatory events, has been emphasized to have diagnostic value in acute abdominal pain by Chi and colleagues (17).…”

Section: Discussionmentioning

confidence: 99%

The Role of Neutrophil/Lymphocyte Ratio in Ovarian Torsions

Büyük,

Karacar Büyük,

Suman

et al. 2024

Sağlık Bilimlerinde Değer

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Aim: Ovarian torsion is among the gynecological emergencies. Laboratory and imaging methods are used for diagnosis. Symptoms are generally nonspecific, making it difficult to differentiate from other acute abdominal emergencies. This study aims to investigate the diagnostic value of neutrophil-lymphocyte ratio (NLR) in addition to imaging methods for the diagnosis of ovarian torsion. Material and Methods: A total of 120 patients were included in the study. The study was planned retrospectively. The patients included in the study were analyzed in three different groups. Those with follicular cysts were in Group 1, those with simple cysts were in Group 2, and those with ovarian torsion were in Group 3. The groups were compared in terms of laboratory parameters and demographic characteristics. Results: When the groups were compared in terms of mean age, it was found that the mean age of Group 3 was significantly lower than Group 1 (p

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Section: Discussionmentioning

confidence: 99%

The Role of Neutrophil/Lymphocyte Ratio in Ovarian Torsions

Büyük,

Karacar Büyük,

Suman

et al. 2024

Sağlık Bilimlerinde Değer

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“…Increased expression of GLUT1 is associated with shorter survival times in ovarian cancer patients and predicts a shorter time for recurrence (DFI) in patients who achieve remission. [16][17][18][19][20]…”

Section: Discussionmentioning

confidence: 99%

High Random Blood Glucose Level before Surgery as a Risk Factor for Recurrent Event in Epithelial Ovarian Carcinoma

Hapsari

Iskandar

2022

Indones J Obstet Gynecol

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Abstract Objective : To investigate the high random blood glucose level as a risk factor for recurrent disease in EOC patient at Kariadi General Hospital. Methods: Sixty six patients diagnosed as EOC in Kariadi General Hospital were divided into 2 groups: 30 patients with recurrent disease and 30 patients without recurrent disease after completing chemotherapy cycles. We analysed correlation between age of diagnosis, tumour mass location, Ca-125 level, histological subtype and random blood glucose level before surgery with recurrent disease. Result: There is no significantly difference in age of diagnosis, tumour mass location and histological subtypes between two groups. However, recurrent EOC patients have higher Ca-125 level significantly than non-recurrent patients (327.8±250.5 vs 183.5±212.1 respectively; p = 0,01). Mean of random blood glucose level of recurrent patients is also higher than non-recurrent patients significantly (150.5 ±79 vs 110.8 ± 31.1 respectively; p = 0.006). Patient with random blood glucose level > 110 mg/dl have 3 times more likely to develop recurrence in EOC patient significantly with 95% CI. Conclusion: The mean of random blood glucose level in recurrent EOC patients is significantly higher than non-recurrent EOC patients. Patient with random blood glucose level > 110 mg/dl have 3 times more likely to develop recurrence in EOC patient. Keyword: epithelial ovarian cancer, random blood glucose level, recurrent. Abstrak Tujuan: Untuk membuktikan kadar glukosa darah sewaktu yang tinggi sebagai faktor risiko kejadian residif pada pasien karsinoma ovarium epitelial di RSUP dr. Kariadi. Metode: Enam puluh pasien yang telah didiagnosis sebagai karsinoma ovarium epitelial di RSUP dr. Kariadi dibagi menjadi 2 kelompok: 30 pasien pada kelompok residif dan 30 pasien pada kelompok non-residif berdasarkan evaluasi setelah menyelesaikan siklus kemoterapi. Data yang dianalisis meliputi usia saat terdiagnosis, lokasi tumor, kadar Ca-125, subtipe histologi, kadar gula darah sewaktu (GDS) sebelum operasi dan hubungannya dengan kejadian residif. Hasil: Tidak terdapat perbedaan yang bermakna dalam usia saat diagnosis, lokasi tumor dan subtipe histologis diantara kedua kelompok. Namun, kelompok pasien residif memiliki kadar Ca-125 yang lebih tinggi secara bermakna dibandingkan kelompok pasien non-residif (327,8 ± 250,5 vs 183,5 ± 212,1; p = 0,01). Rerata kadar GDS pada kelompok pasien residif juga lebih tinggi secara bermakna daripada kelompok non-residif (150,5 ± 79 vs 110,8 ± 31,1; p = 0,006). Pasien dengan kadar GDS > 110 mg/dl memiliki risiko 3 kali lipat untuk menjadi residif secara bermakna dengan tingkat kepercayaan 95%. Kesimpulan: Rerata kadar GDS pada kelompok pasien residif lebih tinggi secara bermakna dibanding kelompok pasien non-residif. Pasien dengan kadar GDS > 110 mg/dl memiliki risiko 3 kali lipat untuk menjadi residif Kata kunci: kadar gula darah sewaktu, karsinoma ovarium epitelial, residif.

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Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR

Zhang

Jiang

et al. 2023

J Ovarian Res

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Ovarian cancer (OC) is one of the deadliest malignant tumors affecting women worldwide. The predictive value of some blood inflammatory composite markers in OC has been extensively reported. They can be used for early detection and differential diagnosis of OC and can be used for predicting survival, treatment response, and recurrence in the affected patients. Here, we reviewed the predictive values of composite inflammatory markers based on complete blood count, namely neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio, and systemic inflammation index and markers based on blood protein, namely C-reactive protein-to-albumin ratio and prognostic nutritional index in OC, with a focus on NLR and PLR. We referred to the clinical studies on these six markers, reviewed the patient population, and summarized the marker cut-off values, significance, and limitations of these studies. All these studies were retrospective and most of them were single-center clinical studies with small sample sizes. We found that the cut-off values of these markers have not been unified, and methods used to determine these values varied among studies. The predictive value of these markers on survival was mainly reflected in the postoperative patients of multiple subtypes of ovarian cancer including epithelial OC, high-grade serous ovarian carcinoma, and ovarian clear cell carcinoma. We focused on NLR and PLR and calculated their pooled hazard ratios. NLR and PLR were reliable in predicting overall and progression-free survivals in patients with OC. Therefore, it is necessary to adjust important confounding factors and conduct a long-term follow-up prospective cohort study to further clarify the cut-off values of NLR and PLR and their clinical applications.

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Laboratory predictors of survival in ovarian cancer

Cited by 3 publications

References 25 publications

The Role of Neutrophil/Lymphocyte Ratio in Ovarian Torsions

The Role of Neutrophil/Lymphocyte Ratio in Ovarian Torsions

High Random Blood Glucose Level before Surgery as a Risk Factor for Recurrent Event in Epithelial Ovarian Carcinoma

Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR

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