Platelet-to-lymphocyte ratio (PLR) and Plateletcrit (PCT) in young patients with morbid obesity

Abstract

SUMMARY OBJECTIVE To compare the complete blood counts, namely the plateletcrit (PCT) and Platelet-To-Lymphocyte Ratio (PLR) of healthy subjects and those with morbid obesity in the young population. METHODS We included 45 patients with morbid obesity (body mass index -BMI - greater than or equal to 45 kg/m2) and 45 healthy subjects (BMI less than or equal to 25 kg/m2) in our study. Blood samples were obtained from the participants following a 12-hour fasting period. Then we evaluated the levels of hemoglobin (Hb), hematocrit (HCT), red cell distribution width (RDW), mean platelet volume (MPV), white blood cell (WBC), PLR, platelet counts, and PCT in the complete blood count. RESULTS The morbid obesity group had significantly higher platelet counts and PCT values (p<0.001), and PLR values (p=0.033). The value of WBC was also higher in the obese group (p=0.001). MPV was lower in the obesity group but not statistically significant (p=0.815). No significant difference was found between hemoglobin and hematocrit values in these groups; but RDW valuewere higher and statistically significant in the obese group (p=0.001). CONCLUSION PLR or PCT may be more useful as a marker in determining an increased thrombotic state and inflammatory response in morbid obesity.

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“…The values for Low risk <1.6, Medium risk 1.6-2.4 and High risk >2.4. (10) PLR is calculated by dividing the platelet count by the lymphocytes [44]. The cut off is <150.…”

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“… 33 The results of our study demonstrated that T2DM patients with DPN had significantly higher fibrinogen, lower BMI, and slightly but not significantly decreased MPV and PDW, and BMI was positively associated with MPV and PDW (data not shown), indicating that obese patients have higher MPV and PDW levels than non-obese patients, and weight loss could lead to lower MPV levels, in agreement with previous studies. 38 , 39 Moreover, serum TBA levels were positively associated with MPV and PDW, and negatively with PLT, PCT and fibrinogen, and the subjects in the higher serum TBA quartiles exhibited higher levels of MPV and PDW, and lower PLT and fibrinogen compared with those in the lowest quartile, suggesting that serum TBA might exertathero-protective effects by inhibiting platelet activation and function. Previous studies also revealed that BAs were associated with platelet dysfunction through membrane deformity and inhibited the thrombin response, 40 , 41 and taurocholic acid reduced clot strength via inhibiting platelet activation and aggregation, and promoted tissue plasminogen activator-mediated fibrinolysis.…”

“…PCT values, the percentage of platelets in blood per unit volume, may provide us with more accurate and comprehensive insight into total platelet mass and their functions, and now became a cardiovascular disease marker. 37 , 38 Fibrinogen, the major coagulation protein in blood by mass, has been independently associated with incident cardiovascular disease outcomes associated with increased blood viscosity. 33 The results of our study demonstrated that T2DM patients with DPN had significantly higher fibrinogen, lower BMI, and slightly but not significantly decreased MPV and PDW, and BMI was positively associated with MPV and PDW (data not shown), indicating that obese patients have higher MPV and PDW levels than non-obese patients, and weight loss could lead to lower MPV levels, in agreement with previous studies.…”

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“…Plateletcrit is the ratio of the volume of platelets to the total blood volume, and it is an indicator of total platelet mass. [17] It is generally correlated with MPV and PDW. Increased plateletcrit has been associated with poor prognosis in thromboembolic events.…”