Analysis of survival in patients with brain metastases treated surgically: Impact of age, gender, oncologic status, chemotherapy, radiotherapy, number and localization of lesions, and primary cancer site

Abstract

SUMMARY OBJECTIVE To evaluate the survival of patients with brain metastases treated surgically according to the potentially involved factors. METHODS 71 patients treated surgically were analyzed with the diagnosis of brain metastases during the period from January 2011 to November 2014, totaling 47 months of follow-up. The Kaplan-Meier curve method was used for survival analysis. Results We evaluated 71 patients with brain metastases treated surgically, 44 female and 27 male, mean age of 60.1 years. According to the Karnofsky scale, 44 patients were classified with Karnofsky greater than or equal to 70 and 27 patients with Karnofsky inferior to 70. Lung was the primary site most commonly found. Death occurred in twenty patients (28%), and lung tumors were responsible for the most deaths. Twelve patients had supra and infratentorial metastases, fifty-nine only had supratentorial lesions, and lesions were multiple in twenty-eight patients and single in forty-three. Thirty patients were also treated with chemotherapy, eighteen with chemotherapy and radiation therapy, while only three received just radiotherapy. Survival analysis by Kaplan-Meier curve showed no statistical significance regarding age, histological type, location, Karnofsky, chemotherapy, and radiotherapy. There was statistical significance regarding gender. CONCLUSION The factors analyzed did not change survival rates, except for gender. This fact may probably be explained due to the systemic and diffuse behavior of cancer.

Retrospective analysis of survival in patients with brain metastases from an unknown primary tumor

“…The frequency of metastatic cerebral tumors is increased due to improved systemic disease control, advanced imaging modalities, and increased use of routine screening for staging. a statistically significant prognostic effect on survival in this study despite previous publications (11). Finally, in a study with an enrollment of 71 subjects, Rotta et al reported that only gender affects survival, without any noticeable effects of age, histological type, KPS, location of cerebral metastases, and treatment type on survival (11).…”

“…a statistically significant prognostic effect on survival in this study despite previous publications (11). Finally, in a study with an enrollment of 71 subjects, Rotta et al reported that only gender affects survival, without any noticeable effects of age, histological type, KPS, location of cerebral metastases, and treatment type on survival (11). Similarly our results showed that surgically (metastasectomy) treated patients had similar outcomes and survival rates with those not treated with surgery.…”

“…The lung was the major primary location of the metastatic disease (74.5%); however, breast cancer constituted only a small part (3.6%). In previous publications, the rate of breast cancer was reported to be higher and was attributable to the heterogeneity of our study population (11,12).…”

“…In 2018, The National Institute for Health and Care Excellence reported a series of 298 patients with brain metastasis in which 55 subjects categorized as brain metastasis from unknown primary (6). In another study, Rotta et al reported 71 subjects (11). Both studies highlighted the scarcity of data regarding brain metastases of unknown primary.…”

The Concordance of Recursive Partitioning Analysis (RPA) Class Stratification with Survival of Brain Metastases Patients in Mohammad Hoesin Hospital, Palembang, Indonesia

“…A total of 78 patients with BM were eligble for this survival of BM patients in different setting . (9)(10)(11)(12)(13)(14)(15)(16) Several previous studies have shown that characteristic primary tumor and the treatment strategy before BM diagnosed was significant to the course of BM. (11.17) Lung cancer is the most common primary tumor and usually diagnosed at the same time of the diagnosed BM (synchronous).…”