Assessment of quality of life in patients with advanced oral cancer who underwent mandibulectomy with or without bone reconstruction

Abstract

INTRODUCTION Malignant neoplasms of the head and neck, due to its anatomical location, can cause significant alterations in vital functions related to feeding, communication and social interaction of the affected patients. Objective To analyze the quality of life of patients with advanced malignant neoplasms of the oral cavity and submitted to radical operations with curative intent. Material and methods 47 patients with oral cavity squamous cell carcinoma (SCC), in stages III and IV, underwent surgical treatment with segmental mandibulectomy and complementary radiotherapy. The patients were submitted to the quality of life questionnaires after a minimum time of six months after the surgical treatment. Results Of the 183 patients, only 47 (25.7%) were able to answer the questionnaire and were included as the sample of the study. The majority of patients selected were male (39; 82.9%). The mean age was 64.4 years. The majority of the patients presented clinical stage IV (83%) and were submitted to adjuvant radiotherapy (95.4%). The mean score obtained after the questionnaires were applied was 64.6. The worst scores were found in swallowing and chewing. Conclusion There were no statistically significant differences in the domains of quality of life between the two groups studied (with bone reconstruction versus no bone reconstruction). Patients interviewed 2 years or more after treatment presented higher scores (p = 0.02).

Mastication in health‐related quality of life in patients treated for oral cancer: A systematic review

“…The included studies involved a total of 1849 oral cancer patients of which at least 1308 were male, as one study did not report sex of patients (Vakil et al, 2012 ). Eleven studies only reported mean or median age with SD and did not mention range (Agarwal et al, 2014 ; Bekiroglu et al, 2011 ; Gu et al, 2021 ; Hoene et al, 2021 ; Larson et al, 2021 ; Rogers et al, 2004 ; Rogers & Lowe, 2020 ; Seferin et al, 2022 ; Soares et al, 2018 ; Wu et al, 2020 ; Zhang et al, 2020 ). One study did not mention age of patients (Vakil et al, 2012 ) and three studies categorised patients in age groups without further details about mean and SD (Rogers & Lowe, 2020 ; Yue et al, 2018 ; Zhang et al, 2020 ).…”

“…One study did not mention age of patients (Vakil et al, 2012 ) and three studies categorised patients in age groups without further details about mean and SD (Rogers & Lowe, 2020 ; Yue et al, 2018 ; Zhang et al, 2020 ). Studies were mainly conducted in China (Fang et al, 2014 ; Fang et al, 2013 ; Gu et al, 2021 ; Li et al, 2013 ; X. Li, Sun, & Guo, 2016 ; W. Li, Zhang et al, 2016 ; Wu et al, 2020 ; Yan et al, 2017 ; Yang et al, 2014 ; Yuan et al, 2016 ; Yue et al, 2018 ; Zhang et al, 2020 ; Zhang et al, 2013 ), followed by India (Agarwal et al, 2014 ; Ghai et al, 2021 ; Sakthivel et al, 2017 ; Vora et al, 2017 ), the United Kingdom (Bekiroglu et al, 2011 ; Devine et al, 2001 ; Rogers et al, 2004 ; Rogers & Lowe, 2020 ), Brazil (Seferin et al, 2022 ; Soares et al, 2018 ), the United States (Larson et al, 2021 ; Ochoa et al, 2021 ), Germany (Hoene et al, 2021 ) and Pakistan (Vakil et al, 2012 ).…”

“…In some studies, patients administered the questionnaire at least once pre‐ and post‐treatment (Agarwal et al, 2014 ; Yan et al, 2017 ). Patients in other studies administered the questionnaire only once post‐treatment (Bekiroglu et al, 2011 ; Devine et al, 2001 ; Fang et al, 2013 ; Fang et al, 2014 ; Ghai et al, 2021 ; Gu et al, 2021 ; Larson et al, 2021 ; Li et al, 2013 ; Li et al, 2016 ; Ochoa et al, 2021 ; Sakthivel et al, 2017 ; Seferin et al, 2022 ; Soares et al, 2018 ; Vakil et al, 2012 ; Vora et al, 2017 ; Wu et al, 2020 ; Yang et al, 2014 ; Yue et al, 2018 ; Zhang et al, 2013 ; Zhang et al, 2020 ). The questionnaire was administered twice post‐treatment in two studies (Rogers & Lowe, 2020 ; Yuan et al, 2016 ).…”

“…The included studies involved a total of 1849 oral cancer patients of which at least 1308 were male, as one study did not report sex of patients (Vakil et al, 2012). Eleven studies only reported mean or median age with SD and did not mention range (Agarwal et al, 2014;Bekiroglu et al, 2011;Gu et al, 2021;Hoene et al, 2021;Larson et al, 2021;Rogers et al, 2004;Rogers & Lowe, 2020;Seferin et al, 2022;Soares et al, 2018;Wu et al, 2020;Zhang et al, 2020).…”

Carcinoma oral de células escamosas en pacientes jóvenes

“…El pilar terapéutico fundamental en el COCE es la resección quirúrgica, la cual, debido a su ubicación anatómica, causa alteraciones significativas en las funciones vitales relacionadas con la alimentación, la comunicación y la interacción social de los pacientes afectados (24).…”