Secondary osteoarthritis to ochronotic arthropathy - a diagnostic challenge

Evangelista, Priscila Dourado; Parente, José Sávio Menezes; Brasileiro, Romano Bezerra; Paiva, José Gerardo Araújo; Freitas, Max Victor Carioca; Moreira, Aline dos Santos; Alves, Ana Paula; Costa, Igor Santos

doi:10.1590/1806-9282.64.07.583

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Symptoms usually manifest in patients ranging from 20 to 50-year-old with a 2:1 male to female ratio[ 2 ]. The end stage of this disease can be accompanied with severe osteoarthritis, known as ochronotic osteoarthropathy[ 3 , 4 ]. Due to the rarity of the disease, initial diagnosis is challenging.…”

Section: Introductionmentioning

confidence: 99%

Ochronotic arthropathy of bilateral hip joints: A case report

Min¹,

Rafi²,

Wang³

et al. 2023

World J Clin Cases

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BACKGROUND Ochronosis, also known as alkaptonuria, is a rare autosomal recessive self-metabolic disease arising from deficiency of homogentisate 1,2 dioxygenase enzyme. It affects several organs and muscoskeletal structures. We herein report a case of a patient who presented with severe hip arthropathy complicated with late stage ochronosis. CASE SUMMARY A 56-year-old male patient was admitted in our department in 2019 with complaints of chronic low backache and left hip pain. After the required investigations were done, lumbar disc herniation and severe hip arthritis were the initial diagnosis. A total left hip arthroplasty was performed. Ochronotic osteoarthritis was only obtained post-surgery as confirmatory diagnosis. He was again admitted mid 2022 with the same complaints on the right hip. Subsequently, he underwent a total right hip arthroplasty. Post-operative recovery and follow-ups were deemed very satisfactory. CONCLUSION Ochronosis is an unusual diagnosis for a patient who presents with typical hip arthritis. Thus, unless meticulous history taking and advanced laboratory tests, the diagnosis can easily be missed by surgeons.

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Section: Introductionmentioning

confidence: 99%

Ochronotic arthropathy of bilateral hip joints: A case report

Min¹,

Rafi²,

Wang³

et al. 2023

World J Clin Cases

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Topical Hydroquinone use leading to Endogenous Ochronosis: A Case Report

Orth,

Phillips Jr.

2020

Journal of Orthopaedic Experience &Amp; Innovation

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Ochronosis is a rare disease characterized by skin pigment changes and degenerative arthritis caused by deposition of homogentisic acid in joint cartilage. There are exogenous and endogenous forms of the disease with the endogenous form typically caused by alkaptonuria, or a defect in homogentisic acid oxidase enzyme. In this report we present a previously undocumented case of endogenous ochronosis caused by topical hydroquinone use in a 69-year-old Caucasian male without alkaptonuria.

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Secondary osteoarthritis to ochronotic arthropathy - a diagnostic challenge

Cited by 2 publications

References 5 publications

Ochronotic arthropathy of bilateral hip joints: A case report

Ochronotic arthropathy of bilateral hip joints: A case report

Topical Hydroquinone use leading to Endogenous Ochronosis: A Case Report

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