Individualized threshold for tumor segmentation in 18F-FDG PET/CT imaging: The key for response evaluation of neoadjuvant chemoradiation therapy in patients with rectal cancer?

Fagundes, Theara Cendi; Mafra, Arnoldo; Silva, Rodrigo G.; Castro, Ana Carolina G.; Silva, Luciana C.; Aguiar, Priscilla Teixeira; Silva, Josiane A; Eduardo, Paulo; Machado, Alexei Manso Corrêa; Mamede, Marcelo

doi:10.1590/1806-9282.64.02.119

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…A study with 17 patients confirmed the predictive power of tumor segmentation based on PET/ CT imaging for response evaluation in patients with rectal cancer after neoadjuvant CRT therapy. 33 The major strength of DWI and PET/CT lies in the identification of nonresponders who are not candidates for organ preservation. Up to now, DWI and PET/CT are not accurate enough to safely select patients for organ-sparing strategies.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging Value to Predict Pathologic Staging in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiation

Pinta¹,

Martín²,

Sempere³

et al. 2019

tjcd

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Amaç: Bu çalışma, neoadjuvan kemoradyoterapi (CRT) sonrası lokal ileri rektum kanserinin preoperatif olarak yeniden düzenlenmesinde, cerrahi tedavinin bireyselleştirilmesini kolaylaştırmak için manyetik rezonans görüntülemenin (MRG) rolünü değerlendirmek için tasarlanmıştır. Yöntem: MRG öncesi ve sonrasında neoadjuvan CRT alan 117 hastayı inceledik. Tüm hastalara yeniden evreleme için MRG ve takiben CRT bittikten sonra operasyon yapıldı. Bu çalışmanın birincil bitiş noktası, CRT sonrası MRG evrelemesinin patolojik evrelemeye göre doğruluğunu tahmin etmekti.

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Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging Value to Predict Pathologic Staging in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiation

Pinta¹,

Martín²,

Sempere³

et al. 2019

tjcd

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Disease quantification on PET/CT images without explicit object delineation

Tong¹,

Udupa²,

Odhner³

et al. 2019

Medical Image Analysis

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Detection of GLUT-1, Hexokinase-Ii, Ki-67, P53, and P16 Levels and HPV With 18F-Fdg PET/CT in Penile Cancer

SALAZAR,

Júnior,

SANCHEZ

et al. 2023

Preprint

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Introduction: Penile cancer (PC) is a rare tumor. It is associated with chronic inflammation and human papilloma virus (HPV) infection. Recent results of 18F-FDG PET/CT studies have demonstrated the great potential of 18F-FDG PET/CT as a noninvasive tool for assessing PC patients. Cancer cells overexpress transmembrane glucose transporters (GLUTs) and hexokinase (HK) during times of high glucose metabolism. Ki-67 is a nuclear protein linked to DNA replication. In PC, the HPV virus has oncoproteins that can interfere with the activities of the p16 and p53 tumor suppressor proteins associated with DNA replication, leading to changes related to PC carcinogenesis. Purpose: Determine the correlation of the immunohistochemistry positivity of tumor molecular markers related to glucose metabolism, proliferation, and HPV with 18F-FDG uptake in penile cancer. Procedures: Fifty-one patients were selected and underwent 18F-FDG PET/CT-based staging. Semiquantitative analysis was performed using the maximum standardized uptake value (SUVmax) and volumetric SUV (SUV2SD). HPV DNA was extracted and identified. Three pathologists performed immunohistochemistry analysis with anti-GLUT-1, anti-hexokinase-II, anti-Ki67, anti-p16, and anti-p53 antibodies. Results: Of the 51 analyzed patients, 80.6% had invasive usual squamous cell carcinoma (SCC), and 42 patients were HPV+ (52.4%). Warty SCC showed the highest SUV value, and there were significant differences in SUVmax (p=0.015). Higher SUVmax and SUV2SD values were observed in grade 3 tumors. In typical invasive SCC, grade 3, HPV+, p16-negative, p53-negative, GLUT-1 i-3, and HK-II i-3 tumors showed a higher mean SUV. The Ki-67 value was significantly different for grade 3 tumors (p=0.001) and HK-II i-1 tumors (p=0.036). Ki-67 positivity was also higher in HPV-, p16 i-2, p53 i-3, and GLUT-1 i-3 tumors; none of the differences were statistically significant. Conclusions: In PC, high uptake of 18F-FDG correlated with higher expression of glycolytic metabolism markers. There was a trend for positive correlation between increased expression of glucose transport markers and higher histological grade and higher Ki-67 expression. HPV-negative patients showed more significant relationships between PET/CT results and markers of proliferation.

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Individualized threshold for tumor segmentation in 18F-FDG PET/CT imaging: The key for response evaluation of neoadjuvant chemoradiation therapy in patients with rectal cancer?

Abstract: The present study confirmed the predictive power of the variables using a noninvasive individualized methodology for tumor segmentation based on 18F-FDG PET/CT imaging for response evaluation in patients with rectal cancer after neoadjuvant chemoradiation therapy.

Cited by 3 publications

References 31 publications

Magnetic Resonance Imaging Value to Predict Pathologic Staging in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiation

Magnetic Resonance Imaging Value to Predict Pathologic Staging in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiation

Disease quantification on PET/CT images without explicit object delineation

Detection of GLUT-1, Hexokinase-Ii, Ki-67, P53, and P16 Levels and HPV With 18F-Fdg PET/CT in Penile Cancer

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