Analyzing the neuropsychological characteristics and changes in serum markers of patients with chronic cerebral circulation insufficiency

Tang, Jianhua; Zhen, Yuqing; Yu, Ling; Zheng, Juan; Liang, Hui

doi:10.1590/1806-9282.64.01.41

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Patients with recurrent cerebral ischemia will have their own neurological function affected. Serum MBP, S100β, and NSE are specific indicators of neurological function evaluation, and the levels are positively correlated with the severity of the disease [19,20]. Recently, cerebral blood flow of patients with TIA is relatively abnormal, mainly manifested as increased resistance, and both cerebral blood flow and 6 Journal of Healthcare Engineering velocity have a downward trend.…”

Section: Discussionmentioning

confidence: 99%

Clinical Study of Clopidogrel Combined with Huoxue Tongluo Prescription in Improving Transient Ischemic Attack and the Effect on MMP-9, Hcy, and CRP

Chen²,

et al. 2022

Journal of Healthcare Engineering

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Background. This study aimed to explore the clinical study of clopidogrel combined with Huoxue Tongluo prescription in improving transient ischemic attack (TIA) and the effect on MMP-9, Hcy, and CRP. Methods. A total of 84 patients with TIA admitted to our hospital from December 2019 to February 2021 were selected. The patients were divided into the control group (42 cases: not treated with Huoxue Tongluo prescription) and study group (42 cases: treatment with Huoxue Tongluo prescription). The clinical efficacy, adverse reactions, the levels of blood pressure and lipid, blood rheology and cerebral hemodynamics, neurological function-related indicators, MMP-9, Hcy, and CRP of the two groups were compared. Results. The total effective rate in the study group was higher than the control group. Compared with before treatment, the levels of SBP and DBP in both groups decreased memorably after treatment, and those in the study group decreased more particularly than the control group. The levels of LDL, HDL, TC, and TG in the study group were significantly better than those in the control group. The plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and hematocrit of patients in the study group were lower than those in the control group, and the maximum blood flow velocity, minimum blood flow velocity, average blood flow velocity, and average blood flow were higher than those in the control group. The levels of NSE, MBP, and S100β in the study group were more memorably lower than those in the control group. After treatment, the levels of MMP-9, Hcy, and CRP in the study group were significantly lower than those in the control group. There was no obvious difference in the incidence of adverse reactions between the study group and control group. Conclusion. Clopidogrel combined with Huoxue Tongluo prescription can significantly improve the therapeutic effect and reduce the levels of MMP-9, Hcy, and CRP in patients with TIA.

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Section: Discussionmentioning

confidence: 99%

Clinical Study of Clopidogrel Combined with Huoxue Tongluo Prescription in Improving Transient Ischemic Attack and the Effect on MMP-9, Hcy, and CRP

Chen²,

et al. 2022

Journal of Healthcare Engineering

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“…However, no significant difference was found in serum S‐100β levels between patients with post‐stroke depression and patients without post‐stroke depression. In fact, there is still controversy about the relationship between serum S‐100β levels and depression 35–37 . Although anxiety disorder and depression disorder have overlapping biological mechanisms such as decreased serotonin levels in the brain, the changes of neurotransmitters in the brain are not completely consistent 38–40 .…”

Section: Discussionmentioning

confidence: 99%

“…In fact, there is still controversy about the relationship between serum S-100β levels and depression. [35][36][37] Although anxiety disorder and depression disorder have overlapping biological mechanisms such as decreased serotonin levels in the brain, the changes of neurotransmitters in the brain are not completely consistent. [38][39][40] Depression disorder is associated with decreased levels of dopamine and norepinephrine, 41,42 while anxiety disorder is associated with increased levels of these substances.…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke

Wang

Xiao

et al. 2022

Psychogeriatrics

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Background: Post-stroke anxiety (PSA) is a common neuropsychiatric affective disorder occurring after a stroke. Animal experiments have indicated that serum S-100β levels are closely related to anxiety disorder. No clinical study has been done to explore the relationship between serum S-100β levels and anxiety symptoms in patients with acute stroke. The aim of our study was to investigate the association between serum S-100β levels and PSA. Methods: One hundred twenty-six acute stroke patients were recruited and followed up for 1 month. Blood samples were collected within 24 h after admission. The levels of serum S-100β were measured by enzyme-linked immunosorbent assays. Patients with significant clinical symptoms of anxiety and a Hamilton Anxiety Rating Scale score >7 at 1 month after stroke were diagnosed as PSA. Results: Serum S-100β levels in the non-PSA group were lower than the PSA group (838.97 (678.20-993.59) ng/L vs. 961.87 (796.09-1479.59) ng/L, Z = À2.661, P = 0.008). In multivariate analyses, we found that decreased risk of PSA was associated with low tertile serum S-100β levels (≤753.8 ng/L, OR 0.062, 95% CI 0.008-0.475, P = 0.007). Conclusions: Low serum S-100β levels at admission may be associated with the decreased risk of PSA.

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“…Modern medicine believes that chronic cerebral insufficiency is the pre-stage of cerebral infarction and is closely related to various diseases such as vascular dementia and Alzheimer. [1] According to statistics, about 80% of the elderly over 75 will have varying degrees of chronic cerebral insufficiency, and those over 60 will generally appear. [2] Currently, modern medicine's treatment of CCCI patients mainly focuses on controlling the underlying disease, expanding blood vessels, improving cerebral circulation, nourishing the brain nerves, and failing to achieve satisfactory therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

Exploring the active components and mechanism of modified bazhen decoction in treatment of chronic cerebral circulation insufficiency based on network pharmacology and molecular docking

Xu,

Shen,

2023

Medicine

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Modified bazhen decoction (MBZD) is a classical Chinese medicine formula with potential efficacy in the treatment of chronic cerebral circulation insufficiency (CCCI), and its main components and potential mechanisms are still unclear. The study aimed to investigate the active ingredients and mechanism of action of MBZD in treating CCCI through network pharmacology combined with molecular docking. The chemical composition and targets of 11 Chinese herbs in MBZD were retrieved utilizing the traditional Chinese medicine systems pharmacology database and analysis platform platform, and the targets for CCCI were screened by Genecards, online mendelian inheritance in man, therapeutic target database, and comparative toxicogenomics database databases. The targets were genetically annotated with the Uniprot database. We created a compound-target network employing Cytoscape software and screened the core targets for the treatment of CCCI by CytoNCA clustering analysis; the AutoDock Vina program performed molecular docking study of crucial targets. One thousand one hundred ninety-one active compounds were obtained, 2210 corresponding targets were predicted, 4971 CCCI-related targets were obtained, and 136 intersecting genes were identified between them. The central core targets were IL6, MAPK14, signal transducer and activator of transcription 3, RELA, VEGFA, CCND1, CASP3, AR, FOS, JUN, EGFR, MAPK1, AKT1, MYC, and ESR1; gene ontology functional enrichment analysis yielded 911 gene ontology items (P < .01), while Kyoto Encyclopedia of Genes and Genomes pathway enrichment yielded 138 signal pathways (P < .01), primarily including oxidative reactions, vascular regulation, apoptosis, and PI3K-Akt signaling pathway. The molecular docking results showed that the core active component of MBZD had good binding with the main target. This research initially uncovered the mechanism of action of MBZD via multi-component-multi-target-multi-pathway for the treatment of CCCI, providing the theoretical basis for the clinical application of MBZD.

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Analyzing the neuropsychological characteristics and changes in serum markers of patients with chronic cerebral circulation insufficiency

Abstract: CCCI patients who are accompanied by minor depressive disorder have different degrees of cognitive impairment and experience a significant rise in serum CRP, S100B, MBP, HSP-70 and NSE.

Cited by 7 publications

References 20 publications

Clinical Study of Clopidogrel Combined with Huoxue Tongluo Prescription in Improving Transient Ischemic Attack and the Effect on MMP-9, Hcy, and CRP

Clinical Study of Clopidogrel Combined with Huoxue Tongluo Prescription in Improving Transient Ischemic Attack and the Effect on MMP-9, Hcy, and CRP

The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke

Exploring the active components and mechanism of modified bazhen decoction in treatment of chronic cerebral circulation insufficiency based on network pharmacology and molecular docking

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