Growth velocity and weight gain in prepubertal asthmatic children

Abstract

Summary Objective: To evaluate the stature growth rate (GR) and the weight gain of prepubertal asthmatic children. Method: A retrospective cohort study evaluating medical records of 85 children diagnosed with asthma, aged less than 9 years, of both sexes, with at least one year of follow-up in the allergy outpatient clinic. The data on the disease, weights and heights were collected through a standardized questionnaire on two occasions, with an interval of one year. The curves proposed by Tanner were applied for the analysis of the GR, and the Z-score of the GR (ZGR) was calculated. Results: Excess weight (risk for overweight, overweight and obesity) was observed in 31.8% (27/85) of the patients, but there was no association with the severity of asthma. Low GR (ZGR < -2) was found in 13.9% (11/79) of patients, most frequently among children with moderate/severe persistent asthma compared to persistent mild and intermittent forms (7/11 - 63.6% vs. 21/68 - 30.2%, respectively, p=0.047). Use of steroids (dose, type and time of use) was not associated with GR. Conclusion: GR was most affected in children with moderate/severe asthma.

Association Between Long-Term Usage of Different Dosages of Inhaled Glucocorticosteroids and Physical Development of Children With Bronchial Asthma

“…Обобщая приведенные выше данные, можно отметить их противоречивость: хотя в ретроспективных и лонгитудинальных исследованиях не было найдено статистически значимых подтверждений относительно негативного эффекта ИГКС на окончательный (во взрослом возрасте) рост больных БА относительно их здоровых сверстников, в некоторых исследованиях показано дозозависимое подавление роста и увеличение массы тела пациентов на фоне применения ИГКС коротким курсом или курсом средней продолжительности [6,8,10].…”

Association between Bronchial Asthma and Pubertal Delay in Pediatric Patients

“…The authors have shown marked reductions of heights in their subjects with severe asthma. Recently, the results of a retrospective study (18) showed a significant reduction in growth rates in children with moderate or severe asthma and this association is more apparent in those with a co-morbid rhinitis, indicating an important connection between such two conditions.…”

The Asthma Obese Phenotype

“…Waist circumference was negatively associated with eosinophilia [10] and gave an odds ratio (OR) = 1.46 for asthma in females [11]. The relation between asthma and metabolic syndrome seems to be reciprocal, as asthma increases the risk for metabolic syndrome [12] and for obesity [13].…”