Hypomagnesemia and its relation with chronic low-grade inflammation in obesity

Oliveira, Ana Raquel Soares de; Cruz, Kyria Jayanne Clímaco; Silva, Juliana; Morais, Jennifer Beatriz Silva; Freitas, Taynáh Emannuelle Coelho de; Araújo, Rogério Santiago; Marreiro, Dilina do Nascimento

doi:10.1590/1806-9282.63.02.156

Cited by 30 publications

(21 citation statements)

References 46 publications

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“…However, magnesium’s role as a calcium antagonist may be important. Prolonged opening of calcium channels and activation of N-methyl-D-aspartate (NMDA) receptors in the absence of magnesium leads to a cascade of events, which favor the inflammatory process [ 35 ]. In the presence of increased concentrations of intracellular calcium, phagocytic cells are activated leading to increased cytokine production [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Magnesium Intake and Chronic Pain in U.S. Adults

et al. 2020

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Chronic pain is a public health concern and additional treatment options are essential. Inadequate magnesium intake has been associated with chronic pain in some populations. We sought to examine the relationship between dietary magnesium intake and chronic pain in a large, representative cohort of U.S. adults (NHANES). Of the 13,434 eligible adults surveyed between 1999 and 2004, 14.5% reported chronic pain while 66% reported inadequate magnesium intake. The univariate analysis showed a protective effect of increased magnesium intake adjusted for body weight (odds ratio 0.92; 95%; CI 0.88, 0.95; p < 0.001). It remained so even after correcting for socioeconomic and clinical factors as well as total calorie intake (odds ratio 0.93; 95% CI 0.87, 0.99; p = 0.02). The association was stronger in females (odds ratio 0.91; 95% CI 0.85, 0.98; p = 0.01) than males (odds ratio 0.96; 95% CI 0.89, 1.04; p = 0.32). The potential protective effect of magnesium intake on chronic pain warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Relationship between Magnesium Intake and Chronic Pain in U.S. Adults

et al. 2020

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“…Magnesium deficiencies have been reported frequently in obesity [90][91][92][93][94][95][96][97][98][99][100][101]. Different causal factors between obesity and hypomagnesemia have been suggested.…”

Section: Low Magnesium Levels Are Often Seen In Obesitymentioning

confidence: 99%

The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses

Vinke

Wesselink

Orten-Luiten

et al. 2020

IJMS

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Long-term use of proton pump inhibitors (PPIs) is common in patients with muscle wasting-related chronic diseases. We explored the hypothesis that the use of PPIs may contribute to a reduction in muscle mass and function in these patients. Literature indicates that a PPI-induced reduction in acidity of the gastrointestinal tract can decrease the absorption of, amongst others, magnesium. Low levels of magnesium are associated with impaired muscle function. This unwanted side-effect of PPIs on muscle function has been described in different disease backgrounds. Furthermore, magnesium is necessary for activation of vitamin D. Low vitamin D and magnesium levels together can lead to increased inflammation involved in muscle wasting. In addition, PPI use has been described to alter the microbiota’s composition in the gut, which might lead to increased inflammation. However, PPIs are often provided together with nonsteroidal anti-inflammatory drugs (NSAIDs), which are anti-inflammatory. In the presence of obesity, additional mechanisms could further contribute to muscle alterations. In conclusion, use of PPIs has been reported to contribute to muscle function loss. Whether this will add to the risk factor for development of muscle function loss in patients with chronic disease needs further investigation.

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“…Magnesium is the second most abundant intracellular cation and is involved in about 300 biochemical reactions related to anabolic and catabolic actions in the body, such as glycolysis and protein and lipid metabolism [55][56]. The Women's Health Initiative Observational Study (n = 3713 postmenopausal women, aged 50-79 years) reported that intake of dietary magnesium was independently and inversely associated with plasma concentrations of hs-CRP, IL-6, and sVCAM-1 in postmenopausal women after an adjustment for multiple variables including dietary fiber, fruit, vegetables, folate, and saturated and trans-fatty intake [57].…”

Section: Magnesiummentioning

confidence: 99%

Weight Management: Inflammation

Upasana¹

2020

Weight Management

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Nowadays, obesity is considered as one of the fastest escalating nutritional disorders that reached pandemic throughout the world. Obesity is a condition in which overaccumulation of energy in the form of fat happens in an individual's subcutaneous and/or abdominal visceral tissue. It is described as an abnormal growth of adipose tissue due to the enlargement of fat cell size (hypertrophic obesity) or fat cell number (hyperplastic obesity) or a condition of both. Earlier, it was reported that the most common type of obesity that affects the general population is the polygenic form that results from a result of a positive energy balance between energy consumption and its expenditure-or a combination of both. The pandemic of obesity has enforced to analyze the link between the role of inflammation and complications of overweight and obesity. This led to crossroads of the field of nutrition, diet therapy, physiology, immunology, and epidemiology and makes the understanding that they are linked inexplicably. The remodeling of obesity as an inflammatory state has led a wide impression in our conceptualization of obesityrelated diseases. In this chapter, we highlight the endocrine aspect of adipose tissue, the effect of dysregulated secretion of adipokines due to inflammation and dietary components that affect obesity related to inflammation.

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Hypomagnesemia and its relation with chronic low-grade inflammation in obesity

Abstract: Oliveira arS et al. 156rEv assoc mEd Bras 2017; 63(2):156-163

Cited by 30 publications

References 46 publications

Relationship between Magnesium Intake and Chronic Pain in U.S. Adults

Relationship between Magnesium Intake and Chronic Pain in U.S. Adults

The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses

Weight Management: Inflammation

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