The impact of rotavirus vaccination on emergency department visits and hospital admissions for acute diarrhea in children under 5 years

Paulo, Rodrigo Locatelli Pedro; Rodrigues, Andre Broggin Dutra; Machado, Beatriz Marcondes; Gilio, Alfredo Elias

doi:10.1590/1806-9282.62.06.506

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…Diarrhea has multi-causative-agents including virus, bacteria, and protozoa where the common once are rotavirus (the leading), escherichia coli, vibrio cholerae, shigella, entamoeba histolytica, and giardia lamblia [5][6][7][8]. Its' most common risk factors are lack of safe drinking water & using untreated pathogenic water either for drinking or food preparation, poor sewage treatment, and lack of basic sanitation facilities [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Diarrheal Morbidity and Associated Factors among Under-Five Children in Southwest Ethiopia. Institution based cross-sectional study

Kitaba

Dame

Terefe

2022

Preprint

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Background: In opposite to progressing to achieve target 3.2 of Sustainable Development Goals, which is ending preventable deaths of neonates and under-five years child by 2030, diarrheal disease continued to be the major cause of child mortality in developing countries including Ethiopia. Thus, this study aimed to assess the prevalence of diarrheal morbidity and associated factors among under-five children in southwest Ethiopia. Methodology: An institution-based cross sectional study was conducted among 2233 under-five children at three randomly selected public hospitals of southwest Ethiopia from March 1 to November 21, 2021. Data were collected from mothers/guardians of the index children selected by systematic random sampling using structured interviewer administered questionnaire. Data entered by Epi_data v.4.2 were analyzed by multivariable logistic regression. P-value <0.05 and 95% confidence-interval (CI) was used to ascertain statistical significance. Results were presented by tables and text. Result: This study had a response rate of 90.9%. The two-week prevalence of diarrhea among the under-five children was 701(34.53%). The factors associated with it were being female (AOR 0.26; 95%CI=.172-.4), age 12-23 months (AOR 4.37; 95%CI=2.32-8.24), mothers or guardian with no formal education (AOR 3.55; 95%CI=1.97-6.4), being urban resident (AOR 0.48; 95%CI=0.28-0.84), being 1st born (AOR .08; 95%CI=.03-.26), frequent hand washing (AOR .58; 95%CI=.26-.66), washing child utensils by cool-water & soap (AOR 2.8; 95%CI=2.12-3.57), unprotected water (AOR 3.6; 95%CI=2.13-6.13), having latrine (AOR .03; 95%CI=.02-.05), replacing water in storage daily (AOR .02; 95%CI=.004-.05), and child-self feeding (AOR 2.4; 95%CI=1.57-3.74).Conclusion: The prevalence of diarrheal morbidity among under-five children in southwest Ethiopia is unacceptably high. Accordingly, to reduce the morbidity, it is urgent that the parents, health extension workers, the zonal health departments, and all concerned bodies should struggle their best to strengthen the practices of diarrhea preventive methods and to avoid the risk factors.

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Section: Introductionmentioning

confidence: 99%

Diarrheal Morbidity and Associated Factors among Under-Five Children in Southwest Ethiopia. Institution based cross-sectional study

Kitaba

Dame

Terefe

2022

Preprint

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“…Over the last decade, rotavirus vaccines have been introduced in many resource-limited countries. Their impact on morbidity and mortality due to rotavirus diseases have been significant [2], [3], [4], [5], [6].…”

Section: Introductionmentioning

confidence: 99%

A Phase III open-label, randomized, active controlled clinical study to assess safety, immunogenicity and lot-to-lot consistency of a bovine-human reassortant pentavalent rotavirus vaccine in Indian infants

Rathi

Desai

Kawade

et al. 2018

Vaccine

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“…Hasil yang sama dijumpai pada penelitian Paulo dkk bahwa tingkat kejadian diare rawat inap pada anak mengalami penurunan sebesar 40% setelah vaksinasi rotavirus. 17 Penelitian Leshem dkk juga menunjukkan angka kejadian diare rawat inap di rumah sakit setelah vaksinasi rotavirus menurun dari 55% menjadi 31% dan semakin menurun di beberapa tahun berikutnya. Pengenalan vaksin rotavirus secara signifikan dapat menurunkan biaya kesehatan untuk perawatan medis di rumah sakit.…”

Section: Pembahasanunclassified

Hubungan Vaksinasi Rotavirus dengan Kejadian Diare pada Anak Usia 6-24 Bulan di Kota Denpasar

Widiantari,

Cempaka,

Nesa

et al. 2022

eum

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Diarrhea constantly becomes an issue of health because of its high mortality and morbidity. Rotavirus infection is known as the predominant cause of acute diarrhea with severe dehydration and hospitalized diarrhea among children less than five years of age. Therefore, rotavirus vaccination is supposed to provide protective effect against the diarrhea cases. The study was implemented to prove the association between rotavirus vaccination and the diarrhea cases among children 6-24 months of age in Denpasar City. The study used an observation cross-sectional analytic design located at private pediatric clinic in Denpasar City and Puskesmas III Denpasar Utara from January to June 2020. The subjects selected by consecutive sampling technique were 104 children 24-36 months of age who divided into vaccinated and unvaccinated groups. The diarrhea cases were measured retrospectively from 6-24 months of age. The study data were derived through questionnaires, processed and analyzed through chi-square and logistic regression test on SPSS. In this study, the percentage of diarrhea cases in the vaccinated group (15,4%) was smaller than the unvaccinated group (36,5%). The statistical test showed PR = 0,42, 95% CI = 0,271-0,654, and p value = 0,001 (p<0,05) which means that rotavirus vaccination was significantly associated with the diarrhea cases and acts as a protective factor. Keywords : Children, Diarrhea, Rotavirus, Vaccination

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The impact of rotavirus vaccination on emergency department visits and hospital admissions for acute diarrhea in children under 5 years

Cited by 8 publications

References 22 publications

Diarrheal Morbidity and Associated Factors among Under-Five Children in Southwest Ethiopia. Institution based cross-sectional study

Diarrheal Morbidity and Associated Factors among Under-Five Children in Southwest Ethiopia. Institution based cross-sectional study

A Phase III open-label, randomized, active controlled clinical study to assess safety, immunogenicity and lot-to-lot consistency of a bovine-human reassortant pentavalent rotavirus vaccine in Indian infants

Hubungan Vaksinasi Rotavirus dengan Kejadian Diare pada Anak Usia 6-24 Bulan di Kota Denpasar

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