A meta-analysis on uterine transplantation: Redefining the limits of reproductive surgery

Abstract

SUMMARY In September 2014, the first baby grown in a transplanted uterus was born, which represented an astonishing scientific progress that will mark the history of human reproduction. The recipient was a 32-year-old woman with Rokytanski syndrome who became pregnant after a successful embryo transfer and had an uneventful pregnancy, giving birth to a healthy newborn and marking the beginning of a new era. Patients who do not have a uterus or have a dysfunctional uterus now have the chance of dreaming with pregnancy and motherhood. Combining principles of solid organ transplantation and techniques of human reproduction, uterus transplantation is the first ephemeral transplant performed in order to promote reproductive potential of women and may be removed after successful pregnancy. Worldwide, 11 uterine transplantations were performed in patients. Of these, seven maintained their reproductive potential, with viable transplanted uteri and regular menstrual cycles.

Motherhood of women with uterine factor infertility

“…Uterus transplantation decidedly redefined the limits of reproductive surgery and the first post-UTx live birth documented in the literature confirms the success of this procedure [23,24,25].…”

“…However, the attempts to transfer an embryo to the uterus ended in spontaneous abortion before the 6th week of gestation. Uterus transplantations have been attempted in Sweden since 2012 [23,24].…”

“…successful treatment of infertility [26]. Since the transplanted uterus is not connected to the recipient's fallopian tubes, IVF is necessary and the pregnancy is concluded with a C-section [23]. The transplanted organ should be removed after the therapeutic outcome has been achieved, i.e.…”

Uterine transplantation and IVF for congenital or acquired uterine factor infertility: A systematic review of safety and efficacy outcomes in the first 52 recipients

“…Furthermore, it has endorsed the concept of reproductive surgery that was previously introduced with the strategy of ovarian tissue transplantation [12]. In fact, both transplantation procedures are performed with the intent of restoring fertility in non-life-saving situations, rather than improving the chance of survival in life-saving situations [13,14].…”