Outcome of children and adolescents with lymphoblastic lymphoma

Oliveira, M. C.; Sampaio, Keyla C.; Oliveira, Aline Carneiro; Santos, Aieska Dantas; Castro, Lúcia Porto Fonseca de; Viana, Marcos Borato

doi:10.1590/1806-9282.61.05.417

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…The outcome was inferior for pleural or pericardial effusion positive patients comparing with negative ones in adolescent. And in a recent study by Burkhardt 11 , adolescent females with Pre-T-LBL had a worse outcome.…”

Section: Discussionmentioning

confidence: 91%

Patients over 40 years old with precursor T-cell lymphoblastic lymphoma have different prognostic factors comparing to the youngers

Meng

Zhang

Yang

et al. 2018

Sci Rep

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This study aimed to analyze the clinical characteristics and prognostic factors of patients, divided into over 40-year-old group or not, with precursor T-cell lymphoblastic lymphoma (Pre-T-LBL). Based on the retrospective analysis of the clinical data of 59 patients with Pre-T-LBL during the period from December 2010 to December 2015, albumin level, anemia, pleural or pericardial effusion, protocol, therapy response, mediastinal mass, lactate dehydrogenase (LDH), and international prognostic index (IPI) or age-adjusted international prognostic index (aaIPI) were summarized. For patients aged <40 years, factors correlating with poor progression-free survival (PFS) were pleural or pericardial effusion, regimen, albumin level and therapy response. Pleural or pericardial effusion, aaIPI score, regimen, LDH increased, albumin level, therapy response and mediastinal mass were all related with poor overall survival (OS). In the patients aged ≥40 years, only anemia associated with PFS. However, anemia, involvement of bone marrow and therapeutic response were all related with poor OS. In conclusion, the patients with Pre-T-LBL are characterized by a low incidence and bad prognosis. Different prognostic factors can be discovered for patients over 40-year-old with Pre-T-LBL comparing to the youngers. New prognostic evaluation factors should be explored for patients ≥40 years old.

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Section: Discussionmentioning

confidence: 91%

Patients over 40 years old with precursor T-cell lymphoblastic lymphoma have different prognostic factors comparing to the youngers

Meng

Zhang

Yang

et al. 2018

Sci Rep

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“…13 Oliveira et al 14 reported a favourable prognosis of childhood LBL using an intensive chemotherapy regimen derived from acute lymphoblastic leukaemia therapy. Specifically, they reported that 22 (81%) of 27 patients were alive in first complete remission.…”

Section: Case Reportmentioning

confidence: 99%

Imaging findings of childhood B-cell lymphoblastic lymphoma in the mental region: a case report

Lam

Kuribayashi

Sakamoto

et al. 2017

Dentomaxillofacial Radiology

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Lymphoblastic lymphoma (LBL) is an uncommon neoplasm that accounts for about 5% of all non-Hodgkin's lymphomas. Approximately 90% of LBLs are of immature T-cell lineage, with B-cell lymphoblastic lymphoma (B-LBL) accounting for only about 10%. Owing to infrequency, the clinicopathological features and the imaging findings of B-LBL are not well defined. LBLs frequently affect extranodal sites. The most common site is the skin, followed by the bone, and the head and neck region is rarely involved. We report herein a case of childhood B-LBL occurring in the mental region, with emphasis on the findings of several imaging studies, including contrast-enhanced CT, MRI and fluorodeoxyglucose-positron emission tomography/CT.

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Multivariate analysis of prognostic factors of lymphoblastic lymphomas of the mediastinum

Mlika

Khanfir

Mansouri³

et al. 2016

Ann Hematol

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Dear Editor,Lymphoblastic lymphoma (LL) of the mediastinum is a rare tumour accounting for 2 % of non-Hodgkin lymphomas. It is a diagnostic and therapeutic emergency. Positive diagnosis is based on microscopic examination. They are classified as T LL in 85 to 90 % of the cases. Few survival studies have been reported, and our knowledge about these tumours is based on rare case reports and case studies [1]. Our aim was to assess the most relevant factors influencing the survival of patients presenting mediastinal LL.We conducted a retrospective single-centre study over a 16-year period between 2000 and 2015 including all patients presenting mediastinal LL. Patients with other mediastinal lesions were ruled out. Two age groups were identified: the pediatric age lower than 15 years and the adult age superior to 15 years. The tumours were subdivided into localized tumours including stages I and II according to the Ann Arbor classification of lymphoma and disseminated tumours including stages III and IVaccording to the same classification. The nature of the specimen, the gross exam, the microscopic features and the crowding artefacts were recorded. The immunohistochemical study was performed in all cases using a manual method performed by the same technician. The different antibodies included CD3, CD5, CD99, CD1a, CD45, Tdt, Ki-67, CD20, CK, EMA, CD79a, CD15 and CD30 antibodies. A multivariate analysis was performed to compare the sex, the gender and the age in relation to the global survival of the patients using cox model. The SPSS software (version 15.0) was used.Thirty-one T cell LL of the mediastinum were diagnosed. The mean age of the patients was 26 years. A male predominance was noticed with 19 men and 12 women. The global survival was estimated to 85 % at 8 months and 70 % at 12 months with a mean survival of 24 months. The multivariate analysis revealed that the sex was a relevant prognostic factor (p = 0.045). Table 1 illustrates the different results related to the odds ratio, the confidence interval and the p values.This study highlights the bad prognosis of these tumours with a global survival of 24 months versus 43 months in the literature. Many prognostic factors have been reported in the literature [2,3]. The young age is considered as a prognostic factor [4,5]. This was not proved in our study (p = 0.46). The female sex is considered as a prognostic factor either in our study or in the literature review (p = 0.045) [6]. In opposition to the literature, the stage does not seem to play a key role (p = 0.88) [7].Other prognostic factors have been reported in the literature including mir17, mir 19, MYC, bcl2, bcl6 and the c-myc without a real consensus [8,9].Our survival study revealed the prognostic relevance of the gender in LL. The prognostic impact of the subtype of the lymphoma was not highlighted because all the cases diagnosed were of T cell subtype. This fact is concordant to the literature review because the majority of mediastinal LL are of T cell subtype.

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Outcome of children and adolescents with lymphoblastic lymphoma

Abstract: OutcOme Of children and adOlescents with lymphOblastic lymphOma reV assoC med Bras 2015; 61(5):417-422 417

Cited by 8 publications

References 26 publications

Patients over 40 years old with precursor T-cell lymphoblastic lymphoma have different prognostic factors comparing to the youngers

Patients over 40 years old with precursor T-cell lymphoblastic lymphoma have different prognostic factors comparing to the youngers

Imaging findings of childhood B-cell lymphoblastic lymphoma in the mental region: a case report

Multivariate analysis of prognostic factors of lymphoblastic lymphomas of the mediastinum

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