A preliminary analysis of the reduction of chemotherapy waste in the treatment of cancer with centralization of drug preparation

Hyeda, Adriano; Costa, Élide Sbardellotto Mariano da

doi:10.1590/1806-9282.61.04.368

Cited by 10 publications

(8 citation statements)

References 7 publications

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“…It has been previously demonstrated that inefficiency of drug waste minimization may produce a considerable economic loss, though experiences are limited and most studies are dated or focused on other therapeutic areas 9,10,11 .…”

Section: Discussion: Our Department Of Medicalmentioning

confidence: 99%

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2016

IJPSR

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Section: Discussion: Our Department Of Medicalmentioning

confidence: 99%

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2016

IJPSR

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“…27 The cost-saving effect of these strategies has already been studied by several studies. 5,10,12 Currently, both Malaysian and World Health Organisation (WHO) official guidelines do not recommend the use of returned medication as the quality of returned medication cannot be guaranteed. 28,29 In view of the rising global cost of cancer care burden, the authors opine that the practice of re-dispensing, reusing or recycling of returned undiluted cytotoxic drug preparations could play a significant role in lowering the cost of cancer care especially in low and middle countries where cancer burden is rising rapidly.…”

Section: Rising Global Cancer Burden -Existing and Potential Strategimentioning

confidence: 99%

“…reusing or recycling) or reconstitution of these undiluted cytotoxic drugs which are returned in good condition before expiry date. Currently, most of the healthcare costrelated studies on cytotoxic drugs were carried out to evaluate the cost-saving effect of centralised cytotoxic reconstitution pharmacy, 10 cytotoxic drug dose rounding, 11 reuse of opened cytotoxic vials 5,12 and other costsaving measures. 6 Due to the increasing cancer burden and rising expenditures on cancer drugs in Malaysia, appropriate usage and management on unused cytotoxic drug as well as management on wastage of cytotoxic drug are therefore an area worth investigating.…”

Section: Introductionmentioning

confidence: 99%

Parenteral cytotoxic drug wastage at a tertiary hospital in Kuala Lumpur: How much and why?

Ang

Cheah

Abdullah

et al. 2019

J Oncol Pharm Pract

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Purpose To identify the cost and reasons of returned parenteral chemotherapy regimens at a tertiary hospital in Kuala Lumpur, Malaysia. Methods Data were retrospectively extracted from all the Chemotherapy Return Forms in 2016, which is a compulsory documentation accompanying each return of parenteral chemotherapy regimen. The following data were extracted: patient’s diagnosis, gender, location of treatment (i.e. ward/daycare clinic), start date of chemotherapy regimen, type of cytotoxic drug returned, dose of cytotoxic drug returned, number of cytotoxic drug preparations returned and reason for return as well as whether the returned cytotoxic drug preparations could be re-dispensed. The cost of wastage was calculated based on the cost per mg (or per unit) of the particular returned cytotoxic drug. Results One hundred and fifty-nine cases of returned chemotherapy regimen comprising of 231 parenteral cytotoxic drug preparations were analysed. The total cost of returned chemotherapy regimen for 2016 was €3632, with €756 (20.8%) worth of chemotherapy regimens returned due to preventable reasons and €2876 (79.2%) worth of chemotherapy regimens returned due to non-preventable reasons. Approximately 50% of cases returned chemotherapy regimen were due to deterioration of patient’s clinical condition and another 24.5% of cases of returned chemotherapy regimen were attributed to adverse drug reactions. Conclusion Wastage associated to non-preventable reasons such as adverse drug reactions and preventable causes like refusal of patients can be further reduced by using newer healthcare innovations and establishment of written institutional protocols or standard operating procedures as references for in-charge healthcare personnel when cytotoxic drug-related issues occur. Adoption of cost-saving strategies that have been proven by studies could further improve current cost containment strategies.

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“…Dilution is also common, where the concentrated liquid form added to the sterile water for injections or to physiological solution results in a more diluted liquid form (4) . Reusing medication in vials, commercial quantity medication dose, and the intended dose in the therapeutic regimen are of crucial importance in determining the residual volume (5) , which is the volume that remains in the vial after drug reconstitution, dilution and administration.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the presence of residue in the packages, in addition to increasing hospital costs (5) also implies the need for correct disposal, otherwise the residues pose a risk to public health and to the environment (6) . In view of the above, the following question was raised: During the preparation of parenteral antibiotics used in pediatrics, is there excess medication remaining in the vials?…”

Section: Introductionmentioning

confidence: 99%

Residual volume in vials of antibiotics used in pediatrics

Chaves

Bezerra

Lima

et al. 2017

Rev. esc. enferm. USP

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Objective: Quantifying residual volume contained in vials of antibiotics used in pediatrics. Method: This is an experiment involving samples from vials of antibiotics used in a pediatric hospital. Residual volume was identified by calculating the difference in weight measurement before and after the vials were washed. Evaluation of the residual volume difference in the vials was determined by the Wilcoxon non-parametric test for a sample and established at a significance level of 5%. Results: 105 samples of antibiotics were selected. The correct use of the antibiotics oxacillin (88.57%) and ceftriaxone (94.28%) predominated with low residual values. The same did not occur for procaine benzylpenicillin + potassium benzylpenicillin, since a greater residual volume was discarded in 74.28% of the vials. Conclusion: We highlight the need for improvements in managing antibiotics in the institution under study, so that the excess volume of the antibiotics in the vials is used within the acceptable stable time. It is also necessary that the disposal of the residual volume be adequately disposed, since it presents a risk to public health and the environment. DESCRIPTORSResidual Volume; Anti-Bacterial Agents; Infusions, Parenteral; Pediatric Nursing. Residual volume in vials of antibiotics used in pediatricsVolume residual de antibióticos em frascos-ampola utilizados na pediatria Volumen residual de antibióticos en frascos-ampolla utilizados en pediatría

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A preliminary analysis of the reduction of chemotherapy waste in the treatment of cancer with centralization of drug preparation

Abstract: Hyeda a et al. 368rev Assoc med BrAs 2015; 61(4):368-374 ORIGINAL ARTICLEA preliminary analysis of the reduction of chemotherapy waste in the treatment of cancer with centralization of drug preparation

Cited by 10 publications

References 7 publications

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Parenteral cytotoxic drug wastage at a tertiary hospital in Kuala Lumpur: How much and why?

Residual volume in vials of antibiotics used in pediatrics

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