Association of obesity with chronic disease and musculoskeletal factors

Minghelli, Beatriz; Oliveira, Raúl; Nunes, Carla

doi:10.1590/1806-9282.61.04.347

Cited by 22 publications

(16 citation statements)

References 39 publications

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“…It is known that in both humans and mice, an imbalance between TNF-α and adiponectin (a hormone of adipose tissue) seems to play an important role in the progression of steatosis to steatohepatitis. [16,17].…”

Section: Discussionmentioning

confidence: 99%

Echographic analysis of the alterations musculoskeletal associated with endothelial dysfunction and obesity

Coria

Estrada-Cruz

Ordoñez

et al. 2020

Preprint

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Background: Modern imaging plays a central role in the care of obese patients, with an integral focus on its use and accessibility in individuals with this condition with alterations of various organs.Objective. To perform an echographical analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle in obese rats.Methods. Sprague Dawley rats (250±5 g) were used and divided into two groups: control group (C) fed a standard diet and the obese group (Ob), fed with a hyper caloric diet of high fructose-fat for 4 mounts. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography and abdominal ultrasound and musculoskeletal system studies in the lower extremities were performed.Results . Body weight in the Ob group was increased compared to the control group, (p <0.001); in addition, increased glucose, cholesterol and triglycerides of were found in the Ob group vs the C group, (p <0.05), and as well as increased adhesion molecules ICAM-1 and, VCAM-1 (p <0.01). On ultrasound, 75% of the Ob group presented showed 75% fatty liver and distal joint abnormalities.Conclusion . Endothelial dysfunction and changes at the level of the musculoskeletal system with the presence of joint cysts in the posterior region of the distal joint of the lower extremities were observed in obese rodents.

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Section: Discussionmentioning

confidence: 99%

Echographic analysis of the alterations musculoskeletal associated with endothelial dysfunction and obesity

Coria

Estrada-Cruz

Ordoñez

et al. 2020

Preprint

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show abstract

“…Thus, excessive body weight creates greater load stress, which causing joint misalignment (deformities) in the lower extremities and in ammatory and degenerative processes. This condition could decrease physical functioning due to associations with mobility and pain [22].…”

Section: Discussionmentioning

confidence: 99%

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Coria

Estrada-Cruz

Ordoñez

et al. 2020

Preprint

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Background: Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats. Methods: Sprague Dawley rats (250±5g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities. Results: The body weight in the Ob group was increased compared to that in the control group, (p<0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p<0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p<0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities. Conclusion: Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower- extremity joints.

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“…[10][11][12] In this special issue, professional medical scientists; Phillip Bwititi and Kenneth Chinkwo with experience from three continents collaborate to discuss effects of obesity on inflammatory and oxidative stress markers in asthma' as well as a narrative review of current clinical practice on oxidative stress markers in infectious respiratory diseases.…”

Section: Issues Of Management and Monitoring By Laboratory Methods Inmentioning

confidence: 99%

Issues of management and monitoring by laboratory methods in respiratory medicine: editorial introduction

Nwose

2016

Int J Res Med Sci

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Association of obesity with chronic disease and musculoskeletal factors

Cited by 22 publications

References 39 publications

Echographic analysis of the alterations musculoskeletal associated with endothelial dysfunction and obesity

Echographic analysis of the alterations musculoskeletal associated with endothelial dysfunction and obesity

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Issues of management and monitoring by laboratory methods in respiratory medicine: editorial introduction

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