Objective: Acute myopericardial syndromes (myopericarditis and perimyocarditis) are among the most challenging diseases to diagnose and treat in pediatric cardiology. The true incidence of the diseases is unknown because the disease can be subclinical or mild enough to go unrecognized in the context of a viral syndrome. The clinical manifestations of acute myopericardial syndromes vary widely from typical chest pain and electrocardiogram changes to atypical chest pain, non-specified electrocardiography changes and subclinical left ventricular dysfunction. The aim of this study is to help pediatricians in the evaluation and management of these common and complex clinical syndromes. Material and Methods: Patients who had been diagnosed with myopericarditis or perimyocarditis at Dr. Sami Ulus Maternity, Children's Health and Diseases Training and Research Hospital between 2010 and 2019 were retrospectively evaluated. Patients who had a fulminant form of myocarditis or progressing to dilated cardiomyopathy were excluded from the study. The medical records of the patients were examined, and their age, gender, diagnostic tests and diagnosis were all evaluated. Results: During the study period, the records of 260 patients were obtained. 47 patients were excluded from the study because of fulminant myocarditis and progression to dilated cardiomyopathy. Of the remaining 213 patients, 68% were male, 32% were female and the median age was 156 months (32 to 212 months). Patients diagnosed with perimyocarditis and myopericarditis had been admitted with a complaint of chest pain and the diagnosis was made according to their history, physical examination, electrocardiography and echocardiography findings. Conclusion: Pediatricians should be aware of the clinical signs and symptoms that increase the index of suspicion for acute myopericardial syndromes because prompt referral to the emergency department and access to specialists with expertise in the care and support of these patients is imperative.