Estimated glomerular filtration rate in patients with type 2                   diabetes mellitus

Fontela, Paula Caitano; Winkelmann, Eliane Roseli; Ott, Joice Nedel; Uggeri, Douglas Prestes

doi:10.1590/1806-9282.60.06.010

Cited by 22 publications

(16 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As for risk factors, this study found a significant association between older age group (>50 years), and KD. This is consistent with findings from other studies [6,9,11,12]. It was reported that eGFR will decline gradually with age and at the age >50 years whatever the equations were used; 25% of the diabetics will have eGFR <90 mL/min [17].…”

Section: Discussionsupporting

confidence: 91%

“…Our prevalence estimate of KD was lower than 86.3% reported in Jamaica [9] and 82.6% in Kenya [11], but higher than that of 25.3% reported in Brazil [12] and 27.9% in Spain [13]. These differences in KD prevalence might be because of the differences in case difference in creatinine assays and calibration or due to the use of Cockroft-Gault equation for estimation of GFR could also have led to an underestimation of GFR & thus a higher prevalence of KD.…”

Section: Discussioncontrasting

confidence: 87%

See 1 more Smart Citation

Renal Function Assessment Among Diabetic Patients in Asella Referral and Teaching Hospital, Assela, South East Ethiopia

Ayalneh¹

2019

SJCM

View full text Add to dashboard Cite

1.5 million people died due to diabetes and more than half millions of them died because of diabetic kidney diseases in 2015. In Ethiopia, the frequency of chronic complications of diabetes is high and an increased occurrence of nephropathy, peripheral neuropathy, hypertension, and retinopathy was observed with longer duration of diabetes. However, there is limited data on the assessment of renal function among Diabetic patients at country level in general as well as specifically in Asella Referral & Teaching Hospital. Retrospective study method was used and Cockroft-Gault formula was used to calculate the estimated Glomerular Filtration Rate. The data were analyzed using SPSS version-20 software and the Pvalue was calculated to see the statistically significant association (p-value < 0.05) among different parameters. Among the total of 189 study subjects, 123 (65.1%) was found to have evidence of renal damage. Of all 123 patients having renal damage, 76 (40.2%) was stage 2, 4 (2.1%) was stage 4. Diabetic patients whose age is >50 were 0.276 times at risk of developing diabetic renal damage than those aged ≤50 (AOR=0.276, 95% CI (0.133-0.574) p=0.001)

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 87%

Renal Function Assessment Among Diabetic Patients in Asella Referral and Teaching Hospital, Assela, South East Ethiopia

Ayalneh¹

2019

SJCM

View full text Add to dashboard Cite

show abstract

“…The ACR was calculated as albumin (mg)/creatinine (g). Estimated GFR (eGFR) was calculated using the MDRD equation [15]. Glucose levels were determined by enzymatic methods in plasma samples.…”

Section: Subjects and Examinationmentioning

confidence: 99%

Serum Elabela/Toddler Levels Are Associated with Albuminuria in Patients with Type 2 Diabetes

Zhang

Gong

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Elabela (ELA) or Toddler is a recently identified hormone that plays a crucial role in embryonic development through the activation of the apelin receptor (APJ). Our previous study indicated that ELA is highly expressed in adult kidney and the ELA receptor signaling pathway is functional in mammalian systems. Whereas nothing is yet known regarding ELA and diabetic kidney disease (DKD). Here, we evaluated the relationship between serum ELA levels and albuminuria in patients with type 2 diabetes (T2D). Methods: An observational study involving 80 patients divided into groups according to their baseline urinary albumin/creatinine ratio (ACR): Group 1 (ACR ≤ 29 mg/g), Group 2 (ACR = 30–299 mg/g), Group 3 (ACR ≥ 300 mg/g with normal serum creatinine), and Group 4 (ACR ≥ 300 mg/g with increased serum creatinine). The demographic, clinical, and biochemical variables including serum ELA were obtained or measured through disease history, physical examination, or laboratory evidence. Results: The results showed that the serum ELA levels decreased gradually with the deterioration of DKD from the stages of normal albuminuria, microalbuminuria, macroalbuminuria, to macroalbuminuria and elevated serum creatinine. In addition, ELA had a significantly negative correlation with ACR (r = -0.561, P < 0.001), retinopathy (r = -0.424, P < 0.001), serum creatinine (r = -0.269, P = 0.016), SBP (r = -0.249, P = 0.026), DBP (r = -0.261, P = 0.020) and a positive correlation with eGFR (r = 0.318, P = 0.004). Furthermore, stepwise multiple linear regression analysis showed that ACR, retinopathy, and LDL-C were considered the most relevant variables to ELA, and ELA, retinopathy, eGFR, and age were important predictors for ACR (t = -4.546, P = 0.000). Conclusions: To our knowledge, this is the first study to explore the clinical relationship between ELA levels and CKD. Decreased serum ELA levels might be a significant clinical predictor in patients with DKD or even as a promising agent for treating CKD patients.

show abstract

“…However, this method requires urine samples and could show altered results due to collection errors. In clinical practice, measuring of plasma creatinine has been most-used the method to assess kidney function, however it alone is not a sensitive method to assess asymptomatic patients with chronic kidney disease (CKD) (Fontela et al, 2014). Instead, eGFR is the most feasible clinical measure of kidney function (KDIGO, 2013).…”

Section: Introductionmentioning

confidence: 99%

Association between kidney function and Framingham risk score in an admixed population of Brazil

Costa

Freitas

Cruz

et al. 2018

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk development. However, the mechanisms of reduced kidney function with CVD risk are unclear. This study aimed to investigate the association between kidney function and Framingham risk score (FRS) in participants with traditional cardiovascular risk factors and normal estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m² in an admixed population of Brazil. The participants were divided into three groups according to FRS: low risk group with 0% to <10%, moderate risk group with ≥10% to 20% and high risk group with >20%. The eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Data from participants were collected by questionnaire, and blood and urine samples were collected to analyze biochemical markers. A total of 214 subjects aged 53±10 years old was collected. There were 77 individuals in low risk group, 59 in moderate risk group and 78 in high-risk group. Mean eGFR CKD-EPI was 89.39±15.05 mL/min/1.73 m² and 90.74±16.17 mL/min/1.73 m 2 when race adjustment. The results indicated that there is an increasing the cardiovascular risk with a decreased of eGFR, conforming to a significant inverse correlation observed between eGFR and FRS with Spearman correlation (R²=-0.256, p<0.001; R²=-0.224, p=0.001, when adjusted for race). There was a statistically significant difference in eGFR CKD-EPI (p<0.001) and eGFR CKD-EPI with race adjustment (p=0.002) among risk groups. The data suggests that the reduction eGFR is associated with elevated FRS among Brazilian adults without CKD. Furthermore, the results suggest that race adjustment it's not necessary in Brazilian population.

show abstract

Estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Cited by 22 publications

References 18 publications

Renal Function Assessment Among Diabetic Patients in Asella Referral and Teaching Hospital, Assela, South East Ethiopia

Renal Function Assessment Among Diabetic Patients in Asella Referral and Teaching Hospital, Assela, South East Ethiopia

Serum Elabela/Toddler Levels Are Associated with Albuminuria in Patients with Type 2 Diabetes

Association between kidney function and Framingham risk score in an admixed population of Brazil

Contact Info

Product

Resources

About