Oral acetylsalicylic acid and prevalence of actinic keratosis

Schmitt, Juliano Vilaverde; Miot, Hélio Amante

doi:10.1590/1806-9282.60.02.010

Cited by 6 publications

(6 citation statements)

References 55 publications

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“…Regular use of ASA and NSAIDs for more than 6 months is correlated with reduction in the number of AKs . Their use should be questioned due to their influence on the number of AKs and skin tumors.…”

Section: Discussionmentioning

confidence: 99%

A randomized, open, controlled trial of tretinoin 0.05% cream vs. low-dose oral isotretinoin for the treatment of field cancerization

et al. 2019

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A randomized, open, controlled trial of tretinoin 0.05% cream vs. low-dose oral isotretinoin for the treatment of field cancerization Abstract Background Sun exposure may lead to actinic keratoses (AKs), field cancerization, and skin cancer. Effective treatment of AKs and field cancerization is important. Oral and topical retinoids can be used for this purpose. To compare clinical, histological, and immunohistochemical effects of oral and topical retinoid for AKs and field cancerization on face and upper limbs of immunocompetent patients, as well as the impact on quality of life, safety, and tolerability.Methods This study compared 10 mg/day oral isotretinoin (ISO) to 0.05% tretinoin cream (TRE) every other night, associated with sunscreen (SPF 60). Patients of both genders, aged 50-75 years, underwent cryotherapy with liquid nitrogen for AKs at baseline and after 120 days when they were randomized into two groups, TRE (n = 31) and ISO (n = 30), for 6 months. Outcome measures were: number of AKs, histological (thickness of stratum corneum and epithelium) and immunohistochemical parameters (p53, Bcl-2 and Bax), dermatology life quality index (DLQI), and adverse events.Results Both treatments reduced the number of AKs (around 28%), the thickness of stratum corneum, and expression of p53 and Bax. By contrast, the epithelium thickness and Bcl-2 expression increased. There was no difference in the outcomes between TRE and ISO. Both treatments improved quality of life and were well tolerated with minimal side effects. Conclusions Retinoids are effective and safe for field cancerization. Classical treatments for field cancerization (imiquimod and ingenol mebutate) are used for a short period; retinoids may be a good choice to intercalate with them and can be used continuously.

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Section: Discussionmentioning

confidence: 99%

A randomized, open, controlled trial of tretinoin 0.05% cream vs. low-dose oral isotretinoin for the treatment of field cancerization

et al. 2019

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“…Given the multifactorial nature of skin cancer development, it is crucial to employ multivariate approaches to When adjusted for age, phototype, alopecia, and sunexposed occupation, there was no association between gender and AK severity, confirming that gender does not have an independent link to predisposition, as identified in another study in the Brazilian population. 28 This finding is reinforced by other studies indicating that women are more likely to adhere to sunscreen use. [29][30][31] This is the first study assessing risk factors for AK severity using the AKASI as the primary outcome measure.…”

Section: Discussionmentioning

confidence: 72%

Association between calcium channel blockers and the severity of actinic keratosis on face and scalp: a cross‐sectional study

Gioppo,

de Castro Martins,

Santos

et al. 2023

Int J Dermatology

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BackgroundActinic keratosis (AK) is a skin condition associated with age, sun exposure, and immunosuppression. Certain drugs, such as photosensitizing medications and calcium channel blockers (CCBs), have been linked to AK. This study explores the impact of individual, behavioral, and exposure factors on the severity of AKs on the face and scalp.MethodsA multicenter cross‐sectional study was conducted on immunocompetent individuals with at least one AK on their face or scalp and assessed demographic factors, sun exposure and protection, history of skin cancer, and medication use within the last 6 months. The primary outcome was the Actinic Keratosis Area and Severity Index (AKASI) score, and a hierarchical generalized linear model was used to evaluate the variation in AKASI scores, adjusting for gender, age, and skin phototype.ResultsTwo hundred seventy subjects between 39 and 92 years were evaluated. The majority had phototype I or II (77%), male gender (51%), personal history of skin cancer (55%), and low adherence to sunscreen use (29%). The use of photosensitizing medications was reported by 61%. Through multivariate analysis, older age (βSE = 0.14; P < 0.01), lighter skin phototype (βSE = 0.15; P = 0.01), history of skin cancer (βSE = 0.12; P < 0.01), sunburning (βSE = 0.12; P < 0.01), and use of CCBs (βSE = 0.11; P = 0.02) were identified as independent risk factors for AK severity. Photosensitizing drugs were not identified as risk factors.ConclusionOlder age, lower skin phototype classifications, and a personal history of skin cancer were confirmed as severity risk factors for AK, while the use of CCBs was associated with more severe AK.

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“…However, as for hydrochlorothiazide, the results of different studies are contradictory. Conflicting evidence regarding the use of antiplatelet agents comes from a Brazilian case-control study, which demonstrated a protective effect of acetylsalicylic acid on the development of AK [30]. This study enrolled 74 cases and 216 controls, and the median duration of therapy was 36 months.…”

Section: Discussionmentioning

confidence: 99%

Drug Intake and Actinic Keratosis: A Case-Control Study

Sechi

Altobrando

Cerciello

et al. 2021

Dermatol Pract Concept

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Background: Actinic keratosis (AK) is a form of premalignant keratinocyte dysplasia. Recently, the role of photosensitizing drugs in the development of AK has been postulated. Objective: This study evaluated a possible association between the use of photosensitizing drugs and the development of AK. A secondary aim was to identify a possible association between any medication other than those primarily examined and AK. Methods: A single-center, case-control study assessed the cumulative drug exposure of 90 patients with AK and 90 controls visiting a dermatology service for other skin ailments. Before the visit, patients were interviewed to collect data on daily therapy and the lag-time of discontinued drugs within the last 2 years, and to record the drug’s active ingredient, dosage, and duration of therapy. In addition, sociodemographic characteristics including age, sex, educational level, skin phototype, and cumulative sun exposure habits were gathered. Results: By logistic regression, exposures to angiotensin II receptor blockers (ARBs) and antiplatelet agents were identified as independent risk factors for the development of AK. ARB intake was associated with AK only at high exposure (OR = 13.6; 95% CI, 2.0-93.8). The use of antiplatelet drugs was borderline, yet not significant, at low exposure (OR = 3.31; 95% CI, 0.86-12.7), but increased in a dose-dependent manner. The strongest correlation was found at the highest cumulative dose (>1100 dose unit-years (OR = 4.38; 95% CI, 1.16-16.6). Conclusions: High exposure to ARBs and antiplatelet agents may promote AK carcinogenesis in at-risk patients.

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Oral acetylsalicylic acid and prevalence of actinic keratosis

Abstract: Conclusion:The regular use of oral acetylsalicylic acid for more than six months was associated to a lower prevalence of actinic keratosis, especially facial and erythematous ones.

Cited by 6 publications

References 55 publications

A randomized, open, controlled trial of tretinoin 0.05% cream vs. low-dose oral isotretinoin for the treatment of field cancerization

A randomized, open, controlled trial of tretinoin 0.05% cream vs. low-dose oral isotretinoin for the treatment of field cancerization

Association between calcium channel blockers and the severity of actinic keratosis on face and scalp: a cross‐sectional study

Drug Intake and Actinic Keratosis: A Case-Control Study

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