Effectiveness of platelet-rich plasma on post-COVID chronic olfactory dysfunction

Evman, Melis Demirag; Cetin, Zeynep Erdogan

doi:10.1590/1806-9282.20230666

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…This study comprised five distinct investigations [20][21][22][23][24], involving a total of 254 participants.…”

Section: Resultsmentioning

confidence: 99%

“…Data were systematically extracted from the selected eligible studies using a standardized format [15,16]. Information regarding patient number, the grading scale employed for assessing olfactory dysfunction, the incidence or percentage of individuals exhibiting substantial recovery from olfactory dysfunction, and the p-value for the comparison between the treatment and control groups or between pre-treatment and post-treatment outcomes was extracted [17][18][19][20][21][22][23][24][25][26]. The analyzed outcomes included changes in olfactory scores after treatment and the percentage of individuals who significantly recovered from olfactory dysfunction.…”

Section: Data Extraction and Risk Of Bias Assessmentmentioning

confidence: 99%

“…Yan [21] Abo El Naga [22] Lechien [24] Steffens [20] Yan [21] Lechien [24] Lechien [24] Evman [23] Lechien [24] Evman [23] Lechien [24] Proven medical treatments for improving olfactory dysfunction are limited. While corticosteroids are commonly used in clinical practice, their precise mechanism of action remains poorly understood.…”

Section: B C Amentioning

confidence: 99%

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Efficacy of Platelet-Rich Plasma in the Treatment of Persistent Olfactory Impairment After COVID-19: A Systematic Review and Meta-Analysis

Bae,

Kim,

Hwang

2024

J Rhinol

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Background and Objectives: This study aimed to evaluate the impact of topical platelet-rich plasma (PRP) injection on persistent refractory olfactory dysfunction after COVID-19 infection.Methods: A systematic review was conducted, focusing on studies that compared the efficacy of topical PRP treatment with a control group (receiving either placebo or no treatment) in ameliorating olfactory dysfunction. Pre- and post-treatment comparisons were evaluated, along with a subgroup analysis of olfactory function evaluation.Results: The analysis revealed a significant improvement in olfactory scores between 1 to 3 months post-treatment (standardized mean difference=1.4376; 95% confidence interval [CI]=0.5934–2.2818; I2=84.1%) in the treatment group compared to the control group. Moreover, a notable disparity was observed between the two groups in the incidence of substantial recovery from anosmia or hyposmia (odds ratio=8.6639; 95% CI=2.9752–25.2292; I2=0.0%). PRP treatment led to a clinically significant increase in the threshold, discrimination, and identification (TDI) score for the Sniffin’ Sticks test by >5.5 (minimum clinically significant difference; mean difference, 6.3494; 95% CI=4.0605–8.6384; I2=0.0%), as confirmed by verified examinations. The odds ratio for significant improvement among patients after treatment was determined to be 0.7654 (95% CI=0.6612–0.8451). Furthermore, all TDI subdomains exhibited significant and comparable improvements post-treatment.Conclusion: This meta-analysis indicates that the injection of PRP into the olfactory fissure or surrounding mucosal areas is an effective treatment for persistent refractory olfactory dysfunction.

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“…This study comprised five distinct investigations [20][21][22][23][24], involving a total of 254 participants.…”

Section: Resultsmentioning

confidence: 99%

Section: Data Extraction and Risk Of Bias Assessmentmentioning

confidence: 99%

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Efficacy of Platelet-Rich Plasma in the Treatment of Persistent Olfactory Impairment After COVID-19: A Systematic Review and Meta-Analysis

Bae,

Kim,

Hwang

2024

J Rhinol

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Determinants of long-lasting postviral COVID-19 and non-COVID-19 olfactory Dysfunction: The sanctuary theory

Lechien

2024

Medical Hypotheses

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Platelet-Rich Plasma (PRP) in the Treatment of Long COVID Olfactory Disorders: A Comprehensive Review

Maniaci,

Lavalle,

Masiello

et al. 2024

Biomedicines

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Background: Long COVID has brought numerous challenges to healthcare, with olfactory dysfunction (OD) being a particularly distressing outcome for many patients. The persistent loss of smell significantly diminishes the affected individual’s quality of life. Recent attention has been drawn to the potential of platelet-rich plasma (PRP) therapy as a treatment for OD. This comprehensive review aims to evaluate the effectiveness of PRP therapy in ameliorating OD, especially when associated with long-term COVID-19. Methods: We executed a comprehensive search of the literature, encompassing clinical trials and observational studies that utilized PRP in treating OD limited to COVID-19. We retrieved and comprehensively discussed data such as design, participant demographics, and reported outcomes, focusing on the efficacy and safety of PRP therapy for OD in COVID-19 patients. Results: Our comprehensive analysis interestingly found promising perspectives for PRP in OD following COVID-19 infection. The collective data indicate that PRP therapy contributed to a significant improvement in olfactory function after COVID-19 infection. Conclusions: The evidence amassed suggests that PRP is a promising and safe therapeutic option for OD, including cases attributable to Long COVID-19. The observed uniform enhancement of olfactory function in patients receiving PRP highlights the necessity for well-designed, controlled trials. Such studies would help to refine treatment protocols and more definitively ascertain the efficacy of PRP in a broader, more varied patient cohort.

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Effectiveness of platelet-rich plasma on post-COVID chronic olfactory dysfunction

Cited by 4 publications

References 21 publications

Efficacy of Platelet-Rich Plasma in the Treatment of Persistent Olfactory Impairment After COVID-19: A Systematic Review and Meta-Analysis

Efficacy of Platelet-Rich Plasma in the Treatment of Persistent Olfactory Impairment After COVID-19: A Systematic Review and Meta-Analysis

Determinants of long-lasting postviral COVID-19 and non-COVID-19 olfactory Dysfunction: The sanctuary theory

Platelet-Rich Plasma (PRP) in the Treatment of Long COVID Olfactory Disorders: A Comprehensive Review

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