“…We read with interest the article by Baris et al, which is a retrospective, cross-sectional cohort study on 198 pediatric patients with refractory epilepsy and global developmental delay enrolled between July 2018 and July 2021 based on the presence of a pathogenic variant, as assessed by a panel for mutations in genes associated with genetic epilepsy 1 . The most commonly mutated genes in this cohort were the SCN1A and TBC1D24 genes, followed by the CACNA1A and KCNQ2 genes 1 . A pathogenic variant was detected only in three patients ( ALDH7A1, KCNQ2 , and SCN1A ) 1 .…”