Does resveratrol reduce cisplatin-induced ovarian damage?

Abstract

SUMMARY OBJECTIVE: The objective of this study was to investigate the protectiveness of resveratrol on cisplatin-induced damage to the ovary using experimental models. METHODS: A total of 30 female Wistar-Albino rats constituted the research material. The rats were categorized into three groups: Group 1 was administered one milliliter of 0.9% NaCl solution, Group 2 was administered 7.5 mg/kg cisplatin, and Group 3 was administered 7.5 mg/kg cisplatin and 10 mg/kg resveratrol. Ovaries were extirpated in all groups and subjected to biochemical and histopathological tests. Cisplatin-induced damage to ovarian tissue was graded and scored as the total histopathological findings score. The ovarian function was assessed using immunohistochemical staining for c-kit expression. Rats’ malondialdehyde, catalase, and superoxide dismutase levels were determined. RESULTS: The histopathological finding score was significantly higher in Group 2 than in other groups (p<0.05). The superoxide dismutase and catalase levels were significantly higher in Group 3 than in Group 2 (p<0.001 for both cases). The malondialdehyde level was significantly higher in Group 2 than in Group 3 (p<0.001). CONCLUSION: The study findings demonstrated that resveratrol reduced ovarian injury and enhanced biochemical parameters following cisplatin-induced ovary damage in experimental models.

Advances in the role of resveratrol and its mechanism of action in common gynecological tumors

“…CDDP use may result in ovarian hypoplasia or exhaustion ( Meirow, 2000 ; Rossi et al, 2017 ). Ciplak et al (2023) showed that RES prevents and attenuates CDDP toxicity in ovarian follicles by increasing superoxide dismutase and catalase levels and decreasing malondialdehyde levels in OC tissue. Similar results were obtained by Chinwe et al (2018) , who hypothesized that RES promotes follicle-stimulating hormone expression.…”