The relationship between serum leptin, insulin-like growth factor-1, and insulin-like growth factor binding protein-3 levels and clinical parameters in primary fibromyalgia patients

Abstract

SUMMARY OBJECTIVE: The aim of this study was to investigate the levels of leptin, growth hormone, insulin-like growth factor-1, and insulin-like growth factor binding protein-3 and their relations with clinical parameters in patients with primary fibromyalgia and healthy controls. METHODS: Our study was performed on 30 female patients with primary fibromyalgia and 30 healthy controls. The levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 were measured by a two-site immunoradiometric assay. The serum level of leptin was measured by the ELISA kit. RESULTS: The serum level of leptin was significantly higher, but the serum levels of insulin-like growth factor-1 were significantly lower in patients with fibromyalgia syndrome than healthy controls (p<0.001). The leptin level was positively correlated with the Visual Analog Scale, Fibromyalgia Impact Questionnaire score, Beck Depression Inventory score, tender point count, age, and duration of disease (p<0.001), but it was negatively correlated with insulin-like growth factor-1 (p<0.001). The insulin-like growth factor-1 level was negatively correlated with age, Visual Analog Scale, Fibromyalgia Impact Questionnaire and Beck Depression Inventory scores, duration of disease, and tender point count (p<0.001). CONCLUSION: Our results indicate that high levels of serum leptin and low levels of serum insulin-like growth factor-1 may play a role in the physiopathogenesis of fibromyalgia and may be related to some symptoms.

There is currently no evidence that high serum leptin and low insulin-like growth factor-1 levels characterise fibromyalgia

“…IGF-1 was negatively correlated with age, VAS, FMIQS, BDIS, disease duration, and tender point count 1 . It was concluded that increased serum leptin and decreased IGF-1 levels may be involved in the pathogenesis of FM 1 . The study is impressive, but some points should be discussed.…”

“…Leptin levels were positively correlated with VAS score, FMIQS, BDIS, tender point count, and disease duration 1 but negatively correlated with IGF-1 1 . IGF-1 was negatively correlated with age, VAS, FMIQS, BDIS, disease duration, and tender point count 1 . It was concluded that increased serum leptin and decreased IGF-1 levels may be involved in the pathogenesis of FM 1 .…”

“…Serum leptin, tender point count, visual analogue scale (VAS) score, FM impact questionnaire score (FMIQS) and Beck depression inventory score (BDIS) were found to be increased and IGF-1 decreased in FM patients 1 . Leptin levels were positively correlated with VAS score, FMIQS, BDIS, tender point count, and disease duration 1 but negatively correlated with IGF-1 1 . IGF-1 was negatively correlated with age, VAS, FMIQS, BDIS, disease duration, and tender point count 1 .…”

“…We read with interest Atamer et al's article on the serum levels of leptin, growth hormone, insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein-3 in 30 patients with primary fibromyalgia (FM), which were compared with 30 healthy controls 1 . Serum leptin, tender point count, visual analogue scale (VAS) score, FM impact questionnaire score (FMIQS) and Beck depression inventory score (BDIS) were found to be increased and IGF-1 decreased in FM patients 1 . Leptin levels were positively correlated with VAS score, FMIQS, BDIS, tender point count, and disease duration 1 but negatively correlated with IGF-1 1 .…”