Role of mean platelet volume in differential diagnosis of adult-onset Still's disease and sepsis

Abstract

Dear Editor, Luo and colleagues have recently published a study entitled "Role of mean platelet volume in differential diagnosis of adult-onset Still's disease and sepsis" in Revista da Associação Médica Brasileira examining the role of mean platelet volume (MPV) to distinguish adult-onset Still's disease (AOSD) from sepsis 1 . This is a potentially impactful article, since AOSD can be difficult to distinguish from sepsis and other reactive conditions. In particular, the use of complete blood cell count (CBC) data, which is nearly universally available, can provide a cost-effective means to arrive at the correct diagnosis. The goals of this letter are to (1) compare Luo et al's data to earlier work on this subject and (2) add additional comments regarding the clinical application of MPV.We followed the guidelines for systematic reviews of diagnostic accuracy studies 2 and PRISMA guidelines 3 . Because this study used publicly available data, it did not require ethical board approval. We conducted an electronic search using Medline (PubMed interface), Scopus, and Web of Science using the keywords "MPV" or "mean platelet volume" AND "Still disease" OR "Still's disease," without restrictions. The date of the search was January 22, 2022. The titles and abstracts were screened, and the full-text articles were then obtained