Narrative review of Vitex agnus-castus in symptoms in Gynecology

Lopes, Ceci Mendes Carvalho; Fonseca, Ângela Maggio da; Alves, Mayara Souza; Bayer, Luiza Helena Costa Moreira; Veiga, Eduardo Carvalho de Arruda; Sorpreso, Isabel Cristina Espósito; Baracat, Edmund Chada; Soares-Jr, José Maria

doi:10.1590/1806-9282.20220174

Cited by 2 publications

(2 citation statements)

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“…У внутрішньочасточковій стромі термінальної протокової часточкової одиниці (морфофункціональна структурна одиниця МЗ) збільшується кількість фібробластів, активується синтез колагену, внаслідок чого тканина МЗ стає жорсткішою, набуваючи властивостей щільної сполучної тканини. Переважно колагени (насамперед колаген I типу) є основною причиною зміни механічних властивостей екстрацелюлярного матриксу тканин МЗ, що ведуть до підвищення їхньої жорсткості [23,26], що запускає в клітинах МЗ механізм механохемотрансдукції (перетворення механічних подразників на хімічні сигнали), активізуючи проліферативні процеси у фіброгландулярній тканині [8,44]. ПРЛ також чинить пряму стимулювальну дію на проліферативні процеси в МЗ, підсилюючи утворення сполучної тканини.…”

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Possibilities of multi-parameter ultrasonography in diagnostic and evaluation of Vitex agnus-castus treatment of patients with mastodynia and mastopathy

Makarova,

Fedusenko

2023

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Objectives: 1) to determine the elasticity of normal breast tissue (parenchyma and premammary adipose tissue) in healthy women using ultrasound two-dimensional shear wave elastography (2D-SWE); 2) to reveal a possible correlation between increased stiffness of the breast parenchyma and hyperprolactinemia in patients with mastodynia and mastopathy; 3) to evaluate the ability of the Vitex agnus-castus drug to reduce the stiffness of the breast glandular tissue; 4) to objectify the ability of the Vitex agnus-castus drug to affect the thickness of the breast parenchyma, the condition of the milk ducts and cystic changes.Materials and methods. Breast tissue stiffness was investigated using 2D shear wave elastography (2D-SWE) in 32 women aged 18–52 with cyclic mastalgia/mastopathy before and after treatment with Vitex agnus-castus drug. A correlation was made with laboratory parameters (prolactin level), the general condition of the breast according to the results of ultrasonography in gray scale mode. The control group consisted of 78 women without complaints, without signs of diffuse and focal pathology of the mammary glands.Results. The 2D-SWE elastography showed normal values of breast tissue stiffness in women without pathology. 2D-SWE in symptomatic women made it possible to detect increased stiffness of the breast parenchyma, thereby screening for its diffuse changes. At the same time, dynamic changes in the softbreast tissue as a result of the treatment (parenchyma thickness, dilatation of the milk ducts, the presence of simple cystic foci (BI-RADS 2)) were diagnosed, analyzed and compared in grayscale mode ultrasonography (2D). The majority of patients (90,6%) noted a decrease in the level of prolactin after treatment. Statistical evidence of the positive effect of the Vitex agnus-castus drug in the treatment of mastodynia/mastopathy has been proven.Conclusions. Assessment of the basic breast tissue stiffness using 2D-SWE makes it possible to screen patients with its elevated values. This fact makes it possible to assign these women to the risk group of developing breast cancer. Evaluation of changes in the mechanical stiffness properties of the breast soft tissues makes it possible to evaluate and objectify the effectiveness of the treatment.

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Section: вступunclassified

Possibilities of multi-parameter ultrasonography in diagnostic and evaluation of Vitex agnus-castus treatment of patients with mastodynia and mastopathy

Makarova,

Fedusenko

2023

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“…Also, both leaf and fruit extracts have anti-inflammatory and antifungal activities that have been shown by the studies ( Souto et al, 2020 ; Berrani et al, 2021 ). In addition, chasteberry fruit extracts’ anti-prostate, antiepileptic, antiangiogenic and health-promoting effects on gynecological diseases such as menopause, dysmenorrhea, premenstrual syndrome have been proven by in vivo and in human clinical trials ( Saberi et al, 2008 ; Ibrahim et al, 2017 ; Souto et al, 2020 ; Mendes et al, 2022 ).…”

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confidence: 99%

Evaluation of the anti-obesity effect of Sambucus nigra L. (elderberry) and Vitex agnus-castus L. (chasteberry) extracts in high-fat diet-induced obese rats

Ulusoy,

İnal,

Küpeli Akkol

et al. 2024

Front. Pharmacol.

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The aim of this study was to investigate the effects of S. nigra L. and V. agnus-castus L. plants on obesity in vivo. Extracts were prepared from S. nigra leaves, flowers, fruits and from V. agnus-castus leaves, flowers, and fruits using 100% water and 70% ethanol. The total phenol and flavonoid contents of the extracts were quantified spectrophotometrically. The findings revealed that the ethanol extracts of V. agnus-castus and S. nigra flowers had the highest phenolic content, while the ethanol extracts of S. nigra flowers and V. agnus-castus leaves had the highest flavonoid content. Qualification and quantification of the phenolic contents of the extracts were carried out using liquid chromatography-high resolution mass spectrometry (LC-HRMS) analyses. The study investigated the effects of various extracts on plasma levels of leptin, insulin, triiodothyronine (T3), thyroxine (T4), triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and lipase enzyme in obesity-induced rats. The results showed that the ethanol extract of V. agnus-castus flowers, as well as the ethanol and water extracts of V. agnus-castus leaves, resulted in body weight reduction in rats with obesity. Additionally, these extracts were found to decrease serum levels of LDL, triglycerides, leptin, lipase, TNF-α, and IL-1β while increasing levels of HDL and adiponectin. The LC-HRMS results demonstrated that all three extracts exhibited relatively high concentrations of luteolin-7-glycoside and kaempferol, in comparison to the other extracts. The ethanol extract of V. agnus-castus flowers contained 653.04 mg/100 g of luteolin-7-glycoside and 62.63 mg/100 g of kaempferol. The ethanol extract of V. agnus-castus leaves contained 1,720.26 mg/100 g of luteolin-7-glycoside and 95.85 mg/100 g of kaempferol. The water extract of V. agnus-castus leaves contained 690.49 mg/100 g of luteolin-7-glycoside and 194.41 mg/100 g of kaempferol. The study suggests that the ethanol extract of V. agnus-castus flowers and leaves, as well as the water extract of V. agnus-castus leaves, may have potential benefits in treating obesity. However, further controlled clinical studies are necessary to evaluate the clinical efficacy of V. agnus-castus in treating obesity and investigate the in vivo anti-obesogenic effects of luteolin-7-glycoside and kaempferol separately, both in their pure form and in combination.

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Narrative review of Vitex agnus-castus in symptoms in Gynecology

Cited by 2 publications

References 19 publications

Possibilities of multi-parameter ultrasonography in diagnostic and evaluation of Vitex agnus-castus treatment of patients with mastodynia and mastopathy

Possibilities of multi-parameter ultrasonography in diagnostic and evaluation of Vitex agnus-castus treatment of patients with mastodynia and mastopathy

Evaluation of the anti-obesity effect of Sambucus nigra L. (elderberry) and Vitex agnus-castus L. (chasteberry) extracts in high-fat diet-induced obese rats

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