Diagnostic value of serum levels of galanin and obestatin in patients with gastric cancer

Uygur, Furkan Ali; Dişçi, Esra; Peksöz, Rıfat; Öztürk, Nurınnısa; Yıldırgan, M. İlhan; Albayrak, Yavuz

doi:10.1590/1806-9282.20211188

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…One of the most used methods in diagnosing and following many diseases is biomarkers. 23 - 25 These markers can be used alone or with other auxiliary methods. Biomarkers play a critical role in the diagnosis of the disease, early recognition of organ dysfunction, disease risk classification, prognosis, and patient management.…”

Section: Methodsmentioning

confidence: 99%

A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review

Peksöz¹,

Agirman²,

Şentürk³

et al. 2023

Eurasian J Med

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Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection according to the Third International Consensus Definitions for Sepsis and Septic Shock definitions. It is a clinical condition with high morbidity and mortality due to its complex pathophysiology and lack of a complete treatment. It constitutes a significant economic burden because it constitutes a substantial part of intensive care patients, and the treatment process is lengthy and costly. Therefore, early diagnosis and treatment of the disease are essential. After pneumonia, an essential source of sepsis is intra-abdominal infection. Due to the presence of multiple and polymicrobial sources of infection, abdominal sepsis progresses more seriously. The effective treatment of intra-abdominal infection consists of early recognition of the disease, control of the source, appropriate antibiotic therapy, and stabilization in the intensive care setting with an excellent surgical approach. We searched PubMed, EMBASE, MEDLINE, and the Cochrane Library. Two authors reviewed all identified abstracts and selected articles for full-text review. We included original studies assessing mediators in intra-abdominal sepsis. Inflammatory and protein mediators such as acute phase protein and chemokine cytokines play an essential role in intra-abdominal sepsis. In clinical practice, white blood cell count, C-reactive protein, and procalcitonin are the most used parameters in the definition of abdominal infection. Tumor necrosis factor-alpha, interleukin-6, high-mobility group protein B1, and presepsin are other markers with high diagnostic efficiency, even though they are not used routinely. Despite everything, there is a need for highly effective markers that can be used in the diagnosis and follow-up of sepsis. Great hope is attached to these markers. This review aims to discuss the importance of the most used markers in the diagnosis and follow-up of abdominal sepsis and the markers on which there are essential studies in light of current literature.

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Section: Methodsmentioning

confidence: 99%

A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review

Peksöz¹,

Agirman²,

Şentürk³

et al. 2023

Eurasian J Med

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show abstract

“…compared to healthy persons, serum galanin levels decreased in patients with stomach cancer. Study concluded that serum galanin levels could be used as a potential biomarker in the detection of stomach cancer [12]. Galanin has been demonstrated to serve as a regulatory peptide within ovary, controlling preovulatory impulses of LH and prolactin and as well as regulating steroidogenesis in ovarian tissue.…”

Section: Journal Of University Of Anbar For Pure Science (Juaps)mentioning

confidence: 99%

An Association of Galanin with some biochemical parameters in Iraqi Type II Diabetic Patients

abood,

Alaaraji

2023

JUAPS

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Background: The body's ability to produce insulin is affected by a group of chronic metabolic diseases known as diabetes. Someone has high blood sugar, either because the pancreas is not producing enough insulin or because the body's cells are not using insulin that is being produced effectively. Present study tried to explore whether there was any association of galanin with urea, uric acid, creatinine, albumin, globulin, total protein, albumin-to-globulin ratio, fasting glucose in patients with type 2 diabetes. Materials and Methods: This study included 42 patients; and 42 healthy controls (HCs); who served as a control group. Enzyme-linked immunosorbent assay (ELISA) was used to determine the level of galanin in serum. While levels of urea, uric acid, creatinine in addition fasting serum glucose (FSG) were determined by enzymatic colorimetric methods, albumin, globulin and total protein (T. protein) were estimated by colorimetric methods.Results: The Study found that level of serum galanin in patients with type 2 diabetes mellitus (T2DM) was higher compared to healthy subjects (P < 0.0001) and FSG was higher in patients compared to HCs (P < 0.0001). Galanin had a significant positive relationship with FSG, urea, creatinine, and globulin (P < 0.0001). Howeve galanin was found to have a negative correlation with uric acid, T. protein, and albumin, in added ,albumin to globulin (ALB/GLB), P < 0.0001). Studied parameters found in descending order of area under receiver operating curve (AUROC): Galanin was (0.858), FSG (1), urea (0.757), uric acid (0.541), creatinine (0.507), T.Protein (0.530). ), globulin (0.586) and albumin (0.657). While (ALB/GLB) was (0.646). New values of cut-off value for studied variables have been estimated as follows, Galanin ( > 6.14 ng/mL), FSG (> 116.5 mg/dL), Urea (> 30.5 mg/dL), Uric acid (< 4.75 mg/dL), Creatinine (> 0.835 mg/dL), T. Protein (< 7.05 g/dL), Albumin (< 4.35 g/dL), Globulins (> 2.75 g/dL) and ALB/GLB (< 1.545). Conclusion: Serum galanin may be used as a biomarker the detection o. .

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Diagnostic value of serum levels of galanin and obestatin in patients with gastric cancer

Cited by 2 publications

References 25 publications

A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review

A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review

An Association of Galanin with some biochemical parameters in Iraqi Type II Diabetic Patients

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