Comment on “The effect of mutation status, pathological features and tumor location on prognosis in patients with colorectal cancer”

Abstract

Dear Editor, Recently, we read an article "The effect of mutation status, pathological features and tumor location on prognosis in patients with colorectal cancer" that analyzes the prognostic factors of colorectal cancer. According to the clinical follow-up data, the genetic and epigenetic risk factors, such as perineural invasion, stage and grade, gender, age, RAS status, and tumor side, on the prognosis of patients with colorectal cancer were analyzed. This retrospective clinical study is of great significance for guiding clinical treatment, especially as part of a future meta-analysis 1 .However, we have some opinions which we want to discuss with the author: First, the treatment of patients with colorectal cancer during follow-up needs to be clearly described. Patients with colorectal cancer with different stages, pathologies, and molecular types will receive different treatment methods.