Are inflammatory and malnutrition markers associated with metabolic syndrome in patients with sarcoidosis?

Abstract

OBJECTIVE:The study aimed to investigate the use of Neutrophil/lymphocyte ratio, C-reactive protein/albumin ratio, controlling nutritional status, and prognostic nutritional index immune, inflammatory, and malnutrition markers Metabolic syndrome+ in sarcoidosis patients, as an early-stage marker.METHOD: This is a single-center and cross-sectional study that determines the association of Metabolic syndrome in patients with sarcoidosis. Patients were evaluated based on the National Cholesterol Education Program's Adult Treatment Panel III criteria. Neutrophil/ lymphocyte ratio, C-reactive protein/albumin ratio, controlling nutritional status, and prognostic nutritional index values were simultaneously determined through blood test.RESULTS: A total of 253 patients diagnosed with sarcoidosis were included in this study. Metabolic syndrome-was detected in 37.2% of patients. The prevalence was significantly higher in females (p<0.001). Any degree of malnutrition assessed by controlling nutritional status had higher Metabolic syndrome (p=0.035). The Neutrophil/lymphocyte ratio cutoff value was 2.24, sensitivity was 70.53, specificity was 60.13, and Area Under the Curve value was 0.663 for predicting Metabolic syndrome in sarcoidosis patients.CONCLUSION: Neutrophil/lymphocyte ratio and controlling nutritional status are associated with the Metabolic syndrome+ in sarcoidosis patients. Thus, close monitoring of Neutrophil/lymphocyte ratio and controlling nutritional status increase in terms of Metabolic syndrome and immune malnutrition may be important in sarcoidosis patients.

Comment on “Are inflammatory and malnutrition markers associated with metabolic syndrome in patients with sarcoidosis?”

“…We were very pleased to read the article entitled “Are inflammatory and malnutrition markers associated with metabolic syndrome in patients with sarcoidosis?” by Isik and his colleagues 1 . In this article, the authors revealed that neutrophil-to-lymphocyte ratio and controlling nutritional status are associated with the metabolic syndrome (MetS)+ in sarcoidosis patients.…”