Anthropometric clinical indicators of visceral adiposity as predictors of nonalcoholic fatty liver disease

Abstract

OBJECTIVE: This study aims to evaluate the role of anthropometric clinical indicators of visceral adiposity as predictors of NAFLD, identifying the cutoff points based on gender.METHODS: This was a cross-sectional study conducted in patients with or without NAFLD. Waist circumference (WC), body mass index (BMI), waist-to-height ratio (WHtR), Conicity Index (C Index), and lipid accumulation product (LAP) were evaluated.RESULTS: A total of 107 individuals were evaluated, of which 46.7% were diagnosed with NAFLD. Individuals with NAFLD presented higher values of WC, BMI, C Index, LAP, and WHtR when compared with those without NAFLD (p<0.05). For the total sample, the indicators WC, BMI, WHtR, LAP, and C Index had an area under the receiver operator characteristic curve (AUC) above 0.87, with no difference in the prediction of NAFLD in both sexes. WHtR (AUC=0.934) was the indicator of visceral adiposity with the best discriminatory power for NAFLD, followed by LAP (0.919), WC (0.912), C Index (0.907), and BMI (0.877). CONCLUSIONS:The anthropometric clinical indicators of visceral adiposity showed high performance, especially the WHtR indicator, as NAFLD predictors.

The associations between cardiometabolic index and non-alcoholic fatty liver disease

“…Recently, more and more researchers have recently started to use WHtR. In a study of patients with NAFLD, WHtR was found to be the most effective in assessing visceral adiposity, and its ability to identify NAFLD was superior to BMI and WC [29]. A Japanese study of 14,125 participants also supports WHtR as a strong indicator of NAFLD [30].…”

Factores de riesgo de fibrosis avanzada en enfermedad hepática esteatósica asociada a disfunción metabólica en pacientes con diabetes mellitus 2

“…Factores de riesgo clínicos según fibrosis avanzada en enfermedad hepática esteatósica asociada a disfunción metabólica en diabéticos tipo 2. OR=503) observamos fue un factor de riesgo independiente de fibrosis en ambos sexos, se deduce el IMC sirve para estratificar pacientes con riesgo de fibrosis, de forma similar se encontró que el IMC y la circunferencia abdominal herramientas útiles como predictores de fibrosis (21) . De la misma manera, nuestros resultados coinciden con la conclusión que para los pacientes con MASLD, la obesidad podría predecir un peor pronóstico a largo plazo (22) .…”

Diagnostic scores and scales for appraising Nonalcoholic fatty liver disease and omics perspectives for precision medicine

“…Also, the hepatic steatosis index (HSI) which included the alanine transaminase/ aspartate transaminase ratio (ALT/AST) ratio and BMI, and the presence of diabetes mellitus, rules out NAFLD with a cut-off of <30 whereas a cut-off of >36 could detect NAFLD. The lipid accumulation product showed that increased values of this index are associated with moderate and severe steatosis [25]. Other models also used to predict hepatic steatosis are the NAFLD liver fat score and the NAFLD ridge score.…”

“…In this context, biomarkers and scores have been investigated to predict and diagnose NAFLD. These determinations range from clinical (age, sex, diabetes, body mass index), biochemical (aminotransferases and ferritin), metabolic markers (insulin, triglycerides, cholesterol) or other variables related to oxidative stress, inflammation or glucose and lipid metabolism [25]. According to recent guidelines for the diagnosis of NAFLD, minimal or noninvasive approaches should aim to identify the risk of NAFLD among individuals at highest metabolic risk in primary care settings, identify subjects with worse prognosis in secondary and tertiary care settings, monitor disease progression and predict future response to therapeutic intervention in a personalized manner [26,27 ▪ ].…”