Cognitive impairment and metabolic syndrome in a population of Brazilian oldest-old

Hashimoto, Vanessa Yumi; Jacinto, Alessandro Ferrari; Araújo, Lara Miguel Quirino; Cendoroglo, Maysa Seabra; Filho, Clineu de Mello Almada

doi:10.1590/1806-9282.20200940

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Dementia is a common neurological disorder associated with impaired performance in daily activities ( 1 , 2 ). The total number of dementia victims is forecast to increase to 78,000,000 by 2030 and 139,000,000 by 2050 ( 3 , 4 ). Alzheimer’s disease (AD) is the most commonly seen dementia in the aging population, contributing roughly 60–70% of all dementia cases ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

Association between systemic rheumatic diseases and dementia risk: A meta-analysis

Wang

Lin²,

Huang³

et al. 2022

Front. Immunol.

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Background and aimsEpidemiological studies have been conducted on the relationship between systemic rheumatic diseases (SRDs) and dementia. Therefore, we focused on determining the extent of alliances bounded by SRDs, along with the risk of dementia.Materials and methodsTwo independent reviewers assessed all studies retrieved from the PubMed, EMBASE, Scopus, and Web of Science databases between January 1, 2000 and November 30, 2021. Only observational studies that estimated the possibility of dementia in participants with SRD were considered. The random-effects model was applied to forecast pooled risk ratios (RRs) and 95% confidence intervals (CI). Heterogeneity among the studies was evaluated using the Q and I2 statistics. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. Funnel plots were used to calculate the risk of bias.ResultsSeventeen observational studies with 17,717,473 participants were recruited. Our findings showed that among the participants with SRDs, those with osteoarthritis, systemic lupus erythematosus, and Sjogren’s syndrome were highly related to an elevated risk of dementia (pooled RR: 1.31; 95% CI: 1.15–1.49, p<0.001; pooled RR: 1.43; 95% CI: 1.19–1.73, p<0.001; and pooled RR: 1.26; 95% CI: 1.14–1.39, p<0.001, respectively). However, participants with rheumatoid arthritis (RA) were not associated with an increased risk of dementia (pooled RR: 0.98; 95% CI: 0.90–1.07, p<0.001).ConclusionThis systematic review and meta-analysis demonstrated an increased dementia risk among SRDs participants, except for RA.

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Section: Introductionmentioning

confidence: 99%

Association between systemic rheumatic diseases and dementia risk: A meta-analysis

Wang

Lin²,

Huang³

et al. 2022

Front. Immunol.

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Identification of a Link between Suspected Metabolic Syndrome and Cognitive Impairment within Pharmaceutical Care in Adults over 75 Years of Age

et al. 2023

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The prevalence of metabolic syndrome (MetS) and cognitive impairment (CI) is increasing with age. MetS reduces overall cognition, and CI predicts an increased risk of drug-related problems. We investigated the impact of suspected MetS (sMetS) on cognition in an aging population receiving pharmaceutical care in a different state of old age (60–74 vs. 75+ years). Presence or absence of sMetS (sMetS+ or sMetS−) was assessed according to criteria modified for the European population. The Montreal Cognitive Assessment (MoCA) score, being ≤24 points, was used to identify CI. We found a lower MoCA score (18.4 ± 6.0) and a higher rate of CI (85%) in the 75+ group when compared to younger old subjects (23.6 ± 4.3; 51%; p < 0.001). In the age group of 75+, a higher occurrence, of MoCA ≤ 24 points, was in sMetS+ (97%) as compared to sMetS− (80% p < 0.05). In the age group of 60–74 years, a MoCA score of ≤24 points was identified in 63% of sMetS+ when compared to 49% of sMetS− (NS). Conclusively, we found a higher prevalence of sMetS, the number of sMetS components and lower cognitive performance in subjects aged 75+. This age, the occurrence of sMetS and lower education can predict CI.

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Cognitive impairment and metabolic syndrome in a population of Brazilian oldest-old

Cited by 2 publications

References 19 publications

Association between systemic rheumatic diseases and dementia risk: A meta-analysis

Association between systemic rheumatic diseases and dementia risk: A meta-analysis

Identification of a Link between Suspected Metabolic Syndrome and Cognitive Impairment within Pharmaceutical Care in Adults over 75 Years of Age

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