Effects of Dietary Supplementation with Tributyrin and Coated Sodium Butyrate on Intestinal Morphology, Disaccharidase Activity and Intramuscular Fat of Lipopolysaccharide-Challenged Broilers

Abstract

The objectives of this study were to investigate the effects of tributyrin (TB) and coated sodium butyrate (CSB) on intestinal morphology, disaccharidase activity and intramuscular fat of broilers challenged with lipopolysaccharide (LPS). A total of 160 1-day-old healthy Cobb broilers were randomly allocated into four groups: (1) control; (2) LPS, in which broilers were fed a basal diet and intraperitoneally injected with 500 μg/kg LPS on days 38, 40 and 42; (3) TB, in which LPSchallenged broilers were fed basal diet supplemented with 500 mg/kg TB; and (4) CSB, in which LPS-challenged broilers were fed basal diet supplemented with 877 mg/kg CSB. Addition of TB and CSB inhibited (p<0.05) the decrease in villus height in the duodenum and ileum of LPSchallenged broilers, respectively. Both TB and CSB increased (p<0.05) activity of maltase in the small intestine, and TB increased (p<0.05) activity of isomaltase in the ileum. Additionally, dietary addition of TB and CSB decreased (p<0.05) the content of intramuscular fat. In conclusion, dietary supplementation of TB was more effective than CSB in improving intestinal morphology and disaccharidase activity of LPS-challenged broilers, and they both reduced intramuscular fat in the breast and legs.

Gut Microbiota Influence Lipid Metabolism of Skeletal Muscle in Pigs

“…acetate and butyrate in JM might positively contribute to the intramuscular adipogenesis in mouse recipients. Some researchers have reported that dietary supplementation of butyrate can prevent diet-induced insulin resistance and obesity by promoting energy expenditure and induce mitochondria function (46,47) and can decrease IMF content in mice and Broilers (30,48). Here we found a remarkable decrease of colonically derived butyrate in JM compared with that in LM, which might contribute to the higher IMF content in JM.…”

Effects of Tributyrin Supplementation on Growth Performance, Insulin, Blood Metabolites and Gut Microbiota in Weaned Piglets

“…Nazih et al [43] demonstrated that butyrate was the only fatty acid that significantly increased the synthesis and the secretion of ApoA-IV protein, which is a major component of HDL and promotes the synthesis of ApoA-IV-containing HDL [44]. Xiong et al [45] showed that tributyrin supplementation in LPS-challenged broilers increased serum HDL compared to LPS-challenged broilers without any feed supplement. Our study, together with previous results, showed that tributyrin might lead to positive effects on blood lipid regulation.…”

Effects of sodium butyrate stimulation on immune‐related mRNA‐miRNA network in intestine of grass carp

“…Sodium butyrate is a common additive in diets of poultry and livestock. It has been shown to promote intestinal development, regulate immune response, increase nutrient absorption and ameliorate intestinal environment (Hu & Guo, 2007;Kotunia et al, 2004;Liu, Yang et al, 2014). The improved effects on intestinal villi by sodium butyrate feeding have been widely reported in several fish, including tilapia , seabass (Wassef et al, 2019), Arapaima gigas (Luz et al, 2019) and grass carp (Liu et al, 2017;Tian et al, 2017;Zhou et al, 2019).…”

“…after fed sodium butyrate, the pH and isobutyric acid concentration in caecum of weanling pigs are increased (Biagi et al, 2007). Other studies show that sodium butyrate supplementation promotes feed conversion ratio in chicken (Hu & Guo, 2007) and calves (Guilloteau et al, 2009). The immune activities are also regulated by feeding with sodium butyrate supplementation (Huuskonen et al, 2004;Liu, Yang et al, 2014;Zhang et al, 2011).…”