Bacillus Coagulans Enhance the Immune Function of the Intestinal Mucosa of Yellow Broilers

Xu, Liping; Fan, Q; Zhuang, Y; Wang, Q; Gao, Y; Wang, C

doi:10.1590/1806-9061-2015-0180

Cited by 14 publications

(5 citation statements)

References 40 publications

(39 reference statements)

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“…including Bacillus subtilis, B. coagulans , and B. licheniformis etc. have been widely used as commercialized probiotic products for humans and animals (Barbosa et al, 2005; Zhang et al, 2013; Park and Kim, 2014; Haque et al, 2017; Xu et al, 2017). Bacillus spp.…”

Section: Introductionmentioning

confidence: 99%

Intestinal Morphologic and Microbiota Responses to Dietary Bacillus spp. in a Broiler Chicken Model

Wang

Zhang

et al. 2019

Front. Physiol.

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Dietary inclusion of probiotic Bacillus spp. beneficially affect the broiler chickens by balancing the properties of the indigenous microbiota causing better growth performance. The effects of three Bacillus spp. on the growth performance, intestinal morphology and the compositions of jejunal microflora were investigated in broiler chickens. A total of 480 1-day-old male Arbor Acres broilers were randomly divided into four groups. All groups had six replicates and 20 birds were included in each replicate. The control birds were fed with a corn-soybean basal diet, while three treatment diets were supplemented with Bacillus coagulans TBC169, B. subtilis PB6, and B. subtilis DSM32315 with a dosage of 1 × 109 cfu/kg, respectively. The experiment lasted for 42 days. The compositions and diversity of jejunal microflora were analyzed by MiSeq high-throughput sequencing. The B. coagulans TBC169 group showed marked improvements of growth performance, nutrient digestibility and intestinal morphology compared with the other B. subtilis treatments. B. coagulans TBC169 supplementation improved the average body weight (BW), average daily weight gain (ADG), total tract apparent digestibility of crude protein and gross energy (GE), and reduced feed conversion rate (FCR) compared with the control group (P < 0.05). The villus height to crypt depth ratio (VH/CD) of jejunum and duodenum was increased in the birds fed with B. coagulans TBC169 compared with the control group (P < 0.05). However, two B. subtilis treatments presented more positive variation of the jejunum microflora of chickens than that in the B. coagulans TBC169 group. B. subtilis PB6 and B. subtilis DSM32315 treatments improved the diversity of jejunal microbiota on day 21 compared with the control (P < 0.05), while which were decreased on day 42 (P < 0.05). The supplementation with B. coagulans TBC169 significantly improved the proportion of Firmicutes, otherwise two B. subtilis significantly improved the proportion of Proteobacteria, Bacteroidetes, Actinobacteria, and Acidobacteria at the phylum level during starter phase and decreased the proportion of Bacteroidetes during growing phase compared with the control. The supplementation with B.subtilis DSM32315 significantly improved the proportion of Clostridiales during starter phase, whereas two B. subtilis significantly improved the proportion of Pseudomonas, Burkholderia, Prevotella, DA101 during growing phase at the genus level compared with the control. In conclusion, the dietary supplementation with probiotic Bacillus spp. strains improved body weight and intestinal morphology in broiler chickens, which might be associated with the gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Intestinal Morphologic and Microbiota Responses to Dietary Bacillus spp. in a Broiler Chicken Model

Wang

Zhang

et al. 2019

Front. Physiol.

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“…Besides, B. coagulans can enhance gut immune functions such as phagocytosis, the activity of NK, T, and B cells, and increase the expression of IgA, IgG, and IgM (Kodali & Sen, 2008;Xu et al, 2017). As mentioned before, the intestinal microbiota limits pathogens such as Salmonella infection, one of the mechanisms referred to as colonization resistance (Wijburg et al, 2006).…”

Section: Discussionmentioning

confidence: 97%

“…It has also been reported that B. subtilis probiotic can be a choice to increase the cecal Lactobacillus count and decrease the count of Salmonella , similar to some antimicrobials such as avilamycin (Park, Yun, & Kim, 2018). Besides, B. coagulans can enhance gut immune functions such as phagocytosis, the activity of NK, T, and B cells, and increase the expression of IgA, IgG, and IgM (Kodali & Sen, 2008; Xu et al, 2017). As mentioned before, the intestinal microbiota limits pathogens such as Salmonella infection, one of the mechanisms referred to as colonization resistance (Wijburg et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of oral administration of mixed probiotic spores of Bacillus subtilis and Bacillus coagulans on gut microbiota changes and intestinal and liver damage of rats infected with Salmonella Typhimurium

Mazkour

Shekarforoush

Basiri

et al. 2022

Journal of Food Safety

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Although the intestinal lumen is a significant way to enter pathogens such as Salmonella, they face a dense microbiota in the gut lumen. This community confers health benefits. Probiotics enhance the colonization resistance and direct inhibition of pathogens, which are essential in reducing the incidence and duration of gastroenteritis and histopathological complications of enteric pathogens. In this study, the spores of two probiotic bacteria, Bacillus subtilis and Bacillus coagulans, were fed to rats for 3 weeks through their daily water intake. After that, Salmonella typhimurium was gavaged to the rats. On days 1, 3, 5, and 7 after gavaging, intestinal microbiota were evaluated, and on days 3, 5, and 7 after gavaging, gut and liver histopathological changes were also evaluated. Salmonella caused no changes in the spore and aerobic bacteria population compared to the control group, but it increased anaerobic and coliform bacteria and reduced lactic acid bacteria (LAB). But B. subtilis and B. coagulans reduced anaerobic and coliform bacteria and decreased the LAB population following Salmonella infection. Also, the histopathological evaluation showed that these probiotics attenuated the shortening and fusion of villi, mononuclear cell infiltration, submucosal edema, and epithelial necrosis in the intestine, hepatocyte degeneration, and mononuclear cell infiltration in the liver, which occurred due to Salmonella infection. B. subtilis and B. coagulans help the maintenance of the gut microflora population and reduce the histopathological effects when exposed to Salmonella, which causes the reduction of these pathogen's effects and early recovery.

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“…showed that chicks fed a diet with 200 mg/kg of Bacillus coagulans significantly increased the villus height/crypt depth ratio at the duodenum compared to the group fed only a basal diet, the amount of the secretory immunoglobulin SIgA has also observed a significant increase (Xu et al 2017). In a study by Y.Y.…”

Section: Improve Intestinal Morphology and Mucosal Immunity In Livestockmentioning

confidence: 93%

Application of Weizmannia coagulans in the medical and livestock industry

Wang

et al. 2022

Ann Microbiol

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Purpose Products enriched with probiotics have always been fashionable. Weizmannia coagulans has become a hot research topic in the academic community due to their multiple functional properties and high resistance to stress, which can retain their activity in a variety of harsh environments. This review aims to evaluate the probiotic effects of different strains of Weizmannia coagulans in animals and humans and to inspire better exploitation of the value of this strain. Methods This review summarizes the latest research progress of Weizmannia coagulans from two major applications in animal breeding and human health. Results The functional properties of Weizmannia coagulans are extensively recognized. In animals, the strain can promote nutrient absorption, reduce mortality, and enhance the slaughter rate in livestock and poultry. In humans, the strain can be used to treat gastrointestinal disorders, immunomodulation, depressive symptoms, and non-alcoholic fatty liver. Weizmannia coagulans is projected as an ideal substitute for antibiotics and other chemical drugs. Conclusion Despite the outstanding functional properties of Weizmannia coagulans, there are numerous strains of Weizmannia coagulans and significant differences between strains in functional and physiological properties. Currently, there are few literature reports on the probiotic mechanism and functional gene identification of Weizmannia coagulans, which is crucial for the commercialization of Weizmannia coagulans and the benefit of human society.

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Bacillus Coagulans Enhance the Immune Function of the Intestinal Mucosa of Yellow Broilers

Cited by 14 publications

References 40 publications

Intestinal Morphologic and Microbiota Responses to Dietary Bacillus spp. in a Broiler Chicken Model

Intestinal Morphologic and Microbiota Responses to Dietary Bacillus spp. in a Broiler Chicken Model

Protective effects of oral administration of mixed probiotic spores of Bacillus subtilis and Bacillus coagulans on gut microbiota changes and intestinal and liver damage of rats infected with Salmonella Typhimurium

Application of Weizmannia coagulans in the medical and livestock industry

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