Effects of Glycyrrhizic Acid on Productive and Immune Parameters of Broilers

Ocampo, C.L.; Gómez-Verduzco, Gabriela; Tapia-Pérez, Graciela; Gutiérrez, O. L.; Sumano, L.H.

doi:10.1590/1806-9061-2015-0135

Cited by 19 publications

(20 citation statements)

References 30 publications

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“…Al‐Daraji () showed that licorice extract, especially at the level of 450 ppm, effectively diminished the detrimental effects of aflatoxicosis on the general physiological status of broiler chickens. Ocampo et al () suggested that broiler growth performance was improved and mortality was decreased by adding glycyrrhizic acid (the main component of licorice extract) to drinking water via promoting immunity system. In consistent to our results, Nosrati et al () reported that supplementation of Echinacea purpurea extract in broiler’s drinking water increased BWG in grower and total rearing phase.…”

Section: Discussionmentioning

confidence: 99%

“…Vaya, Belinky, and Aviram (1997) isolated several constituents from licorice such as isoflavans (Hispaglabridin A, Hispaglabridin B, Glabridin, and 4-O-Methylglabridin), chalcones (isoprenylchalcone derivative and Isoliquiritigenin) and the isoflavone (Formononetin) with antioxidant capacity. Glycyrrhetinic acid is the main component in licorice, and has been used in human medicine (Ocampo, Gómez-Verduzco, Tapia-Perez, Gutierrez, & Sumano, 2016). It has been showed that licorice has anti-microbial (Fukai et al, 2002), and immunity enhancement effects (Fujioka, Kondou, & Fukuhara, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Response of broiler chickens reared at high density to dietary supplementation with licorice extract and probiotic

Rashidi

Ghorbani

Ahmad

et al. 2018

Animal Physiology Nutrition

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This study evaluated the effects of licorice extract and probiotic on performance, excreta characteristics and welfare‐related parameters of broiler chickens reared in high stocking density. Three hundred and thirty‐six 1‐day old broiler chicks (Ross 308) were used in a completely randomized design with five treatments and four replicates for 42 days. Treatments were as follows: (a) positive control (PC, 12 chicks/m2); (b) negative control (NC, 18 chicks/m2); (c) NC + 500 ppm licorice extract (LE); (d) NC + 200 ppm probiotic (P); (e) NC + ppm LE + ppm P. Body weight gain (BWG) was affected negatively by increased density in the growing period (p < 0.05). At high density, BWG was increased in the growing and whole period by adding LE and P separately and in combination (p < 0.01). Feed conversion ratio (FCR) was not affected by stocking density. Excreta weight (g/bird) and dry matter (DM, %) were reduced by increasing density (p < 0.01). Use of feed additives at high stocking density had no significant effect on excreta weight, but DM content of excreta was higher in NC + LE + P than NC. Gait problems and footpad and hock burns were increased by increased stocking density, but were not altered by feed additives. In conclusion, licorice extract and probiotic improved BWG of broilers reared at high stocking density; however, these birds had some disorders in footpad, hock and walking ability.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Response of broiler chickens reared at high density to dietary supplementation with licorice extract and probiotic

Rashidi

Ghorbani

Ahmad

et al. 2018

Animal Physiology Nutrition

View full text Add to dashboard Cite

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“…The active components of licorice and its extracts have anti-inflammatory, immunomodulatory and antiviral functions, and thus can augment the immunity of poultry by modulating both humoral and cell-mediated immune responses, prevent viral diseases, and render supplementary treatment for viral diseases [35,36]. Omer et al [35] reported that LE (60 mg/100 mL Glycyrrhiza extract) when used as a phytogenic feed additive exhibited antiviral activity against the Newcastle disease virus (NDV).…”

Section: Beneficial Role Of Licoricementioning

confidence: 99%

Use of Licorice (Glycyrrhiza glabra) Herb as a Feed Additive in Poultry: Current Knowledge and Prospects

Alagawany

Elnesr

Farag

et al. 2019

Animals

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Simple SummaryThe present review updates the current knowledge about the beneficial effect of licorice supplementation in poultry diets, particularly its positive effect on the treatment of high-prevalence diseases of the immune system, liver, and lungs.AbstractSupplementation of livestock and poultry diets with herbal plants containing bioactive components have shown promising reports as natural feed supplements. These additives are able to promote growth performance and improve feed efficiency, nutrient digestion, antioxidant status, immunological indices, and poultry health. Several studies have used complex herbal formulas with the partial inclusion of licorice. However, the individual use of licorice has been rarely reported. The major problem of the poultry industry is the epidemiological diseases, mainly confined to the respiratory, digestive, and immune systems. Licorice has certain bioactive components such as flavonoids and glycyrrhizin. The roots of this herb contain 1 to 9% glycyrrhizin, which has many pharmacological properties such as antioxidant, antiviral, anti-infective and anti-inflammatory properties. Licorice extracts (LE) have a positive effect on the treatment of high-prevalence diseases such as the immune system, liver, and lung diseases. Studies showed that adding LE to drinking water (0.1, 0.2, or 0.3 g/L) reduced serum total cholesterol (p < 0.05) of broiler chickens. Moreover, LE supplementation in poultry diets plays a significant role in their productive performance by enhancing organ development and stimulating digestion and appetite. Along with its growth-promoting effects, licorice has detoxifying, antioxidant, antimicrobial, anti-inflammatory, and other health benefits in poultry. This review describes the beneficial applications and recent aspects of the Glycyrrhiza glabra (licorice) herb, including its chemical composition and role in safeguarding poultry health.

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“…This effect has already been reported in chickens. 20,21 Glycyrrhizic acid is known to stimulate gastrointestinal motility and enzyme secretion. 32 Additionally, it has been shown to possess other pharmacological properties including anti-inflammatory, antiulcer, anti-allergic, immune-modulating and antiviral properties.…”

Section: Original Researchmentioning

confidence: 99%

“…In broiler chickens, glycyrrhizic acid stimulates weight gain, and this effect is linked to immune-related effects. 20 This was observed even in chickens affected by infectious bronchitis. 21 Furthermore, glycyrrhizic acid augments the survival of shrimp affected with the viral disease known as white spot syndrome, 22 and again, an Original Research immune-mediated mechanism is proposed.…”

Section: Introductionmentioning

confidence: 98%

Effects of glycyrrhizic acid (Viusid-Vet® powder) on the reduction of influenza virus spread and on production parameters in pigs

Ocampo-Camberos¹,

Tapia²,

Gutiérrez³

et al. 2017

Vet Méx OA

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Influenza viruses are among the most important respiratory pathogens in pigs and humans. They cause seasonal epidemics in pigs and occasional pandemics in humans. Herbal remedies have been regarded as suitable elements to aid in controlling influenza. This study was carried out to analyse the effects of the in-feed administration of glycyrrhizic acid, the best-known component of liquorice (as Viusid-Vet® powder), in pigs suffering an outbreak of influenza. Eighty crossbred Duroc-Landrace pigs, one day post-weaning (22 days old), were included in this trial. Piglets were randomly divided into the following two groups: those treated with glycyrrhizic acid and an untreated control group. Serological measurements to assess viral load and humoral responses were carried out. Blood samples from pigs were obtained every fortnight, starting on week two and ending on week 15. With these samples, haemagglutination inhibition (HI) tests were performed, using A/swine/New Jersey/11/76 (H1N1) and A/swine/Minnesota/9088-2/98 (H3N2) as reference viruses. Quantitative RT-PCR tests against the M gene of the influenza virus were also performed to assess viral shedding from nasal swab samples on weeks 1 to 8 after the beginning of the trial. Weight variables were assessed weekly for 18 weeks. In the HI tests, treated animals showed fewer positive responses compared to the control group for H1N1 and H3N2. However, a positive response to viral protection, as assessed by HI tests, was regarded as not conclusive of humoral immune stimulation. qRT-PCR tests for viral spread exhibited a lower rate of excretion for the treated group compared to the untreated one. Hence, it appears that glycyrrhizic acid stimulates, to some extent, immune responses against pig influenza as measured by viral shedding. For mean body weight, the generalized estimating equations show a higher weight gain for pigs treated with glycyrrhizic acid than the control group (P = 0.0001). These effects may assist producers in addressing the aftermath of an influenza outbreak.

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Effects of Glycyrrhizic Acid on Productive and Immune Parameters of Broilers

Cited by 19 publications

References 30 publications

Response of broiler chickens reared at high density to dietary supplementation with licorice extract and probiotic

Response of broiler chickens reared at high density to dietary supplementation with licorice extract and probiotic

Use of Licorice (Glycyrrhiza glabra) Herb as a Feed Additive in Poultry: Current Knowledge and Prospects

Effects of glycyrrhizic acid (Viusid-Vet® powder) on the reduction of influenza virus spread and on production parameters in pigs

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