Loss to follow-up and missing data: important issues that can affect your study results

Ferreira, Juliana Carvalho; Patino, Cecilia María

doi:10.1590/1806-3713/e20190091

Cited by 14 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Up to know, there are no agreed upon standards regarding the amount of missing data. It has been reported that a loss of 20% of the sample or greater suggests heightened possibility of bias, likely mistrusting the study results 93 and therefore should not be acceptable 94 . It has been reported that even 5%–20% of missing data (due to dropouts and loss to follow-up) are potentially leading to bias 13,95 …”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that a loss of 20% of the sample or greater suggests heightened possibility of bias, likely mistrusting the study results 93 and therefore should not be acceptable. 94 It has been reported that even 5%-20% of missing data (due to dropouts and loss to follow-up) are potentially leading to bias. 13,95 In addition, it has been suggested that when dropouts are less than 20% and similar courses of disease in the groups analyzed, strategies to deal with missing data can be performed; however, when the dropouts are higher than 20% and the courses of the disease are different, no recommendations can be provided.…”

Section: Missing Data: Sensitivity Analysismentioning

confidence: 99%

See 1 more Smart Citation

Are Biases Related to Attrition, Missing Data, and the Use of Intention to Treat Related to the Magnitude of Treatment Effects in Physical Therapy Trials?

Armijo‐Olivo

Costa

Ha³

et al. 2021

Am J Phys Med Rehabil

View full text Add to dashboard Cite

The objective of this study was to determine the association between biases related to attrition, missing data, and the use of intention to treat and changes in effect size estimates in physical therapy randomized trials. A meta-epidemiological study was conducted. A random sample of randomized controlled trials included in meta-analyses in the physical therapy discipline were identified. Data extraction including assessments of the use of intention to treat principle, attrition-related bias, and missing data was conducted independently by two reviewers. To determine the association between these methodological issues and effect sizes, a two-level analysis was conducted using a meta-meta-analytic approach. Three hundred ninety-three trials included in 43 meta-analyses, analyzing 44,622 patients contributed to this study. Trials that did not use the intention-to-treat principle (effect size = −0.13, 95% confidence interval = −0.26 to 0.01) or that were assessed as having inappropriate control of incomplete outcome data tended to underestimate the treatment effect when compared with trials with adequate use of intention to treat and control of incomplete outcome data (effect size = −0.18, 95% confidence interval = −0.29 to −0.08).Researchers and clinicians should pay attention to these methodological issues because they could provide inaccurate effect estimates. Authors and editors should make sure that intention-to-treat and missing data are properly reported in trial reports.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Missing Data: Sensitivity Analysismentioning

confidence: 99%

Are Biases Related to Attrition, Missing Data, and the Use of Intention to Treat Related to the Magnitude of Treatment Effects in Physical Therapy Trials?

Armijo‐Olivo

Costa

Ha³

et al. 2021

Am J Phys Med Rehabil

View full text Add to dashboard Cite

show abstract

“…When a participant withdraws or is lost from the study prior to the end of the observation period, it is collectively called ‘loss to follow‐up’. The validity of a study may be adversely affected by a lack of detail regarding loss to follow‐up and it is therefore essential to describe participants lost to follow‐up in the Results section and the reason for their loss (Ferreira & Patino, 2019). For example, if a participant in a pulp capping trial does not wish to attend the follow‐up because they had a pulpectomy during an emergency visit due to pain, not accounting for this patient would lead to a possible overestimation of the success rate of the treatment.…”

Section: Process Involved In Developing the Preferred Reporting Items...mentioning

confidence: 99%

PROBE 2023 guidelines for reporting observational studies in endodontics: Explanation and elaboration

Nagendrababu¹,

Duncan

Fouad

et al. 2023

Int Endodontic J

View full text Add to dashboard Cite

Observational studies play a critical role in evaluating the prevalence and incidence of conditions or diseases in populations as well as in defining the benefits and potential hazards of health‐related interventions. There are currently no reporting guidelines for observational studies in the field of Endodontics. The Preferred Reporting Items for study Designs in Endodontology (PRIDE) team has developed and published new reporting guidelines for observational‐based studies called the ‘Preferred Reporting items for OBservational studies in Endodontics (PROBE) 2023’ guidelines. The PROBE 2023 guidelines were developed exclusively for the speciality of Endodontics by integrating and adapting the ‘STrengthening the Reporting of OBservational studies in Epidemiology (STROBE)’ checklist and the ‘Clinical and Laboratory Images in Publications (CLIP)’ principles. The recommendations of the Guidance for Developers of Health Research Reporting Guidelines were adhered to throughout the process of developing the guidelines. The purpose of this document is to serve as a guide for authors by providing an explanation for each of the items in the PROBE 2023 checklist along with relevant examples from the literature. The document also offers advice to authors on how they can address each item in their manuscript before submission to a journal. The PROBE 2023 checklist is freely accessible and downloadable from the PRIDE website (http://pride-endodonticguidelines.org/probe/).

show abstract

“…26 The LTF rate was just fewer than 20% which is acceptable, although, rates higher than this can threaten the validity of the results. 27 Future studies should consider strategies to increase participant follow-up and factor in a similar LTF rate into recruitment projections. 28…”

Section: Feasibilitymentioning

confidence: 99%

Can we improve patients’ physical activity levels after discharge by interventions on the Acute Medical Unit? The ‘teachable moment’

MURPHY

Jeune²

2022

Acute Med

View full text Add to dashboard Cite

Introduction: >30% of the population does less physical activity (PA) than recommended and few patients receive PA advice during a hospital admission (2,5). This study aimed to assess the feasibility of recruiting acute medical unit (AMU) in-patients and to examine the effect of delivering PA interventions to them. Methods: In-patients who were inactive (<150mins/wk) were randomised to either a motivational interview (Long Interview, LI) or brief advice (Short Interview, SI). Participants’ physical activity levels were assessed at baseline and at two follow-up consultations. Results: 77 participants were recruited. At 12 weeks 22/39(56.4%) participants were physically active following the LI and 15/38(39.5%) following the SI. Discussion: Recruitment and retention of patients on the AMU was straightforward. PA advice helped a high proportion of participants become physically active.

show abstract

Loss to follow-up and missing data: important issues that can affect your study results

Cited by 14 publications

References 3 publications

Are Biases Related to Attrition, Missing Data, and the Use of Intention to Treat Related to the Magnitude of Treatment Effects in Physical Therapy Trials?

Are Biases Related to Attrition, Missing Data, and the Use of Intention to Treat Related to the Magnitude of Treatment Effects in Physical Therapy Trials?

PROBE 2023 guidelines for reporting observational studies in endodontics: Explanation and elaboration

Can we improve patients’ physical activity levels after discharge by interventions on the Acute Medical Unit? The ‘teachable moment’

Contact Info

Product

Resources

About