Clinical, functional, and cytological evaluation of sputum in postinfectious bronchiolitis obliterans: a possible overlap with asthma?

Maia, Sarah Angélica; Eli, Denise; Cunha, Roberta; Bitencourt, Elessandra; Riedi, Carlos Antônio; Chong-Neto, Herberto José; Silva, Débora Carla Chong e; Filho, Nelson Augusto Rosário

doi:10.1590/1806-3713/e20190060

Cited by 3 publications

(3 citation statements)

References 12 publications

(16 reference statements)

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“…Previous studies have found that patients with PIBO with the positive bronchial dilation test are not significantly associated with a family history of asthma or allergy ( 26 , 27 ). However, some studies have found that more than 50% of patients with PIBO have allergies, and this study suggested that PIBO can coexist with bronchial asthma ( 28 , 29 ). It is difficult to say whether this was a concomitant allergy or a specific symptom of PIBO.…”

Section: Discussionmentioning

confidence: 63%

Effects of Inhaled Corticosteroids on Lung Function in Children With Post-infectious Bronchiolitis Obliterans in Remission

Zheng

Chen

et al. 2022

Front. Pediatr.

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BackgroundPost-infectious bronchiolitis obliterans (PIBO) is a rare and irreversible chronic obstructive pulmonary disease with no specific treatment, especially for patients with PIBO in remission. In this study, we evaluated the effects of continuous inhaled corticosteroids (ICSs) and intermittent ICSs on lung function in the remission of PIBO.MethodsThis was a retrospective study, and all the subjects we included were divided into continuous ICS group and intermittent ICS group according to treatment regimens. Patients in continuous ICS group received continuous ICSs (2 times a day), and patients in intermittent ICS group received intermittent ICSs (inhaled corticosteroids after acute respiratory tract infection or wheezing). Different lung function tests were performed at different ages. Tidal breathing lung function tests were performed in patients with PIBO aged ≤ 5 years, and the lung ventilation function test and the bronchial dilation test were performed in patients with PIBO aged more than 5 years. Lung function was assessed at the beginning of follow-up and at the end of follow-up (1 year of ICSs).ResultsAfter 1 year of ICSs, patients aged more than 5 years, forced vital capacity (FVC), and forced expiratory volume in 1 s (FEV1) were significantly higher than at the beginning of follow-up. After 1 year of ICSs, the difference in VT/Kg, TPTEF/TE, and VPEF/VE between the end and the beginning of follow-up in continuous ICS group shows an upward trend. But those showed a downward trend in intermittent ICS group. FVC, FEV1, and maximal mid-expiratory flow velocity 25–75% (MMEF25–75%) of continuous ICS group were significantly higher than at the beginning of follow-up. The difference in FEV1 and MMEF25–75% between the end of follow-up and the beginning of follow-up in continuous ICS group was significantly higher than that in intermittent ICS group. A total of 52.94% of patients with PIBO aged more than 5 years were positive for bronchial dilation tests.ConclusionInhaled corticosteroids can effectively improve lung function and relieve airway obstruction in patients aged more than 5 years in PIBO remission, especially continuous ICSs. Patients with PIBO may have reversible airflow limitations.

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Section: Discussionmentioning

confidence: 63%

Effects of Inhaled Corticosteroids on Lung Function in Children With Post-infectious Bronchiolitis Obliterans in Remission

Zheng

Chen

et al. 2022

Front. Pediatr.

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“…One-third of the sample presented positive bronchodilator response at spirometry and more than half presented allergic sensitization suggesting that PIBO and asthma may coexist. 5 In conclusion, there are clinical similarities between PIBO and asthma in pediatric population and both could be misdiagnosed.…”

Section: Postinfectious Bronchiolitis Obliterans and Asthma: A Misdia...mentioning

confidence: 94%

Postinfectious bronchiolitis obliterans and asthma: A misdiagnosis or overlap?

Chong-Silva

Botelho

Eli

et al. 2020

Pediatric Pulmonology

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“…El patrón histológico distintivo de la BO constrictiva es la fibrosis peribronquiolar con diferentes grados de estrechamiento de la luz. Aunque se cree que los dos tipos histológicos no están clínica ni temporalmente relacionados, y deben ser considerados diferentes entidades; la diferenciación entre estas dos entidades tiene significado clínico, debido a distintos patrones de pronóstico (Lee, Park, & Yang, 2022) (Maia, et al, 2019).…”

Section: Estudios Histológicos: Biopsia De Parénquima Pulmonarunclassified

Etiología, Fisiopatología, Diagnóstico y Tratamiento de la bronquiolitis Obliterante en Edad Pediátrica, un artículo de revisión

Guerra Marcial,

Montenegro García,

Andrade Cerda

et al. 2023

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Clinical, functional, and cytological evaluation of sputum in postinfectious bronchiolitis obliterans: a possible overlap with asthma?

Cited by 3 publications

References 12 publications

Effects of Inhaled Corticosteroids on Lung Function in Children With Post-infectious Bronchiolitis Obliterans in Remission

Effects of Inhaled Corticosteroids on Lung Function in Children With Post-infectious Bronchiolitis Obliterans in Remission

Postinfectious bronchiolitis obliterans and asthma: A misdiagnosis or overlap?

Etiología, Fisiopatología, Diagnóstico y Tratamiento de la bronquiolitis Obliterante en Edad Pediátrica, un artículo de revisión

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