Neuroactive venom compounds obtained from Phlogiellus bundokalbo as potential leads for neurodegenerative diseases: insights on their acetylcholinesterase and beta-secretase inhibitory activities in vitro
Abstract:Background
Spider venom is a rich cocktail of neuroactive compounds designed to prey
capture and defense against predators that act on neuronal membrane
proteins, in particular, acetylcholinesterases (AChE) that regulate synaptic
transmission through acetylcholine (ACh) hydrolysis - an excitatory
neurotransmitter - and beta-secretases (BACE) that primarily cleave amyloid
precursor proteins (APP), which are, in turn, relevant in the structural
integrity of neurons. The present study provides prelim… Show more
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