The effect of capsaicin on expression patterns of CGRP in trigeminal ganglion and trigeminal nucleus caudalis following experimental tooth movement in rats

Zhou, Yang; Long, Hu; Ye, Niansong; Liao, Lina; Yang, Xin; Fan, Jing; Wang, Yan; Lai, Wenli

doi:10.1590/1678-775720160150

“…The upregulation and release of CGRP are the hallmarks during pain episodes of orofacial pain (36). The release of CGRP to peripheral tissues could induce neurogenic in ammation that exacerbates pain (37,38). And we found CGRP was upregulated and released to periodontal tissues in response to orofacial pain in our previous studies (21,39).…”

Section: Discussionmentioning

confidence: 61%

N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways

Yan

¹

,

Han

²

,

Zhang

³

et al. 2020

Preprint

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Background: Nociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide (CGRP) is a well-known pro-nociceptive molecule that participates in the modulation of orofacial pain. We aimed to determine the effects of N/OFQ on the modulation of orofacial pain and on the release of CGRP.Methods: Orofacial pain model was established by ligating springs between incisors and molars in rats for the simulation of tooth movement. The expression level of N/OFQ was determined and pain level scored in response to orofacial pain. Both agonist and antagonist of N/OFQ receptor were administered to examine their effects on pain and the expression of CGRP in trigeminal ganglia (TG). Moreover, gene therapy based on the overexpression of N/OFQ was delivered to validate the modulatory role of N/OFQ on pain and CGRP expression.Results: Tooth movement elicited orofacial pain and an elevation in N/OFQ expression. N/OFQ exacerbated orofacial pain and upregulated CGRP expression in TG, while UFP-101 alleviated pain and downregulated CGRP expression. N/OFQ-based gene therapy was successful in overexpressing N/OFQ in TG, which resulted in pain exacerbation and elevation of CGRP expression in TG.Conclusions: N/OFQ exacerbated orofacial pain possibly through upregulating CGRP.

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“…The upregulation and release of CGRP are the hallmarks during pain episodes of orofacial pain (38). The release of CGRP to peripheral tissues could induce neurogenic in ammation that exacerbates pain (39,40). And we found CGRP was upregulated and released to periodontal tissues in response to orofacial pain in our previous studies (21,41,42).…”

Section: Discussionmentioning

confidence: 68%

N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways

Yan

¹

,

Han

²

,

Zhang

³

et al. 2020

Preprint

Self Cite

0

View full text Add to dashboard Cite

Background: Nociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide (CGRP) is a well-known pro-nociceptive molecule that participates in the modulation of orofacial pain. We aimed to determine the effects of N/OFQ on the modulation of orofacial pain and on the release of CGRP. Methods: Orofacial pain model was established by ligating springs between incisors and molars in rats for the simulation of tooth movement. The expression level of N/OFQ was determined and pain level scored in response to orofacial pain. Both agonist and antagonist of N/OFQ receptor were administered to examine their effects on pain and the expression of CGRP in trigeminal ganglia (TG). Moreover, gene therapy based on the overexpression of N/OFQ was delivered to validate the modulatory role of N/OFQ on pain and CGRP expression.Results: Tooth movement elicited orofacial pain and an elevation in N/OFQ expression. N/OFQ exacerbated orofacial pain and upregulated CGRP expression in TG, while UFP-101 alleviated pain and downregulated CGRP expression. N/OFQ-based gene therapy was successful in overexpressing N/OFQ in TG, which resulted in pain exacerbation and elevation of CGRP expression in TG. Conclusions: N/OFQ exacerbated orofacial pain possibly through upregulating CGRP.

show abstract

“…The upregulation and release of CGRP are the hallmarks during pain episodes of orofacial pain (36). The release of CGRP to peripheral tissues could induce neurogenic in ammation that exacerbates pain (37,38). And we found CGRP was upregulated and released to periodontal tissues in response to orofacial pain in our previous studies (21,39,40).…”

Section: Discussionmentioning

confidence: 68%

N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways

Yan

¹

,

Han

²

,

Zhang

³

et al. 2020

Preprint

Self Cite

0

View full text Add to dashboard Cite

Background: Nociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide (CGRP) is a well-known pro-nociceptive molecule that participates in the modulation of orofacial pain. We aimed to determine the effects of N/OFQ on the modulation of orofacial pain and on the release of CGRP.Methods: Orofacial pain model was established by ligating springs between incisors and molars in rats for the simulation of tooth movement. The expression level of N/OFQ was determined and pain level scored in response to orofacial pain. Both agonist and antagonist of N/OFQ receptor were administered to examine their effects on pain and the expression of CGRP in trigeminal ganglia (TG). Moreover, gene therapy based on the overexpression of N/OFQ was delivered to validate the modulatory role of N/OFQ on pain and CGRP expression.Results: Tooth movement elicited orofacial pain and an elevation in N/OFQ expression. N/OFQ exacerbated orofacial pain and upregulated CGRP expression in TG, while UFP-101 alleviated pain and downregulated CGRP expression. N/OFQ-based gene therapy was successful in overexpressing N/OFQ in TG, which resulted in pain exacerbation and elevation of CGRP expression in TG.Conclusions: N/OFQ exacerbated orofacial pain possibly through upregulating CGRP.

show abstract

The effect of capsaicin on expression patterns of CGRP in trigeminal ganglion and trigeminal nucleus caudalis following experimental tooth movement in rats

Cited by 22 publications

References 30 publications

N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways

N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways

N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways

N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways

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