Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible

Hwang, Young Sun; Han, Sang-Sun; Kim, Ki-Rim; Lee, Yejin; Lee, Sun-Kyung; Park, Kwang-Kyun; Chung, Won Yoon

doi:10.1590/1678-775720140158

Cited by 6 publications

(13 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The red bone marrow is the most common site of metastatic depositis, due to high vascularization and metabolic activity of the tissue that enable the availability and development of tumor cells. With the ageing process, relatively little active marrow remains in the mandible, which explains the prevalence of metastatic lesions in this area in elderly patients 2 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fine needle aspiration biopsy of mandible: an effective alternative to conventional biopsy for the differential diagnosis between metastasis and osteonecrosis in oncologic patients treated with bisphosphates - Case report

Baldi¹,

Pinto²,

Ferrari³

et al. 2017

J Oral Diag

View full text Add to dashboard Cite

Bisphosphonates are the drugs of choice for the prevention and treatment of bone metastases of breast cancer, especially in more advanced cases. Osteonecrosis of the jaw (BRONJ) is the most common, debilitating complication of the use of this drug, caused mainly by bone manipulation. Because of this, the indication for biopsy for differential diagnosis is critical in cases of radiographic findings without mandibular exposure, and less invasive diagnostic methods have been discussed in the literature. The objective of this study was to describe a case of differential diagnosis of mandibular metastasis of breast cancer and BRONJ by fine needle aspiration (FNA). A 67-year-old woman was referred to the Dentistry and Stomatology Service of Ribeirao Preto General Hospital, Brazil, in January 2015, for investigation of pain followed by paresthesia in the lower lip. The patient had a history of mixed breast carcinoma in 1999, recurrent in 2010, treated with chemotherapy and Zometa from 2010 to 2013. Although no significant alterations were detected at clinical examination, the CT scan revealed osteolytic lesions involving the anterior and posterior right jaw. Because of the risk of bone necrosis after biopsy, FNA was chosen as the diagnostic method. Cytology confirmed metastasis of breast cancer and the patient had no complications in the puncture area. FNA was shown to be a viable, safe option for differential diagnosis between BRONJ and mandibular bone metastasis.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Its relatively high survival rates (61% in the first five years) have been associated with the occurrence of chronic conditions, including metastasis 1 . Approximately 11% of metastatic tumor to the jaw originates from breast cancer 2 .…”

Section: Introductionmentioning

confidence: 99%

Fine needle aspiration biopsy of mandible: an effective alternative to conventional biopsy for the differential diagnosis between metastasis and osteonecrosis in oncologic patients treated with bisphosphates - Case report

Baldi¹,

Pinto²,

Ferrari³

et al. 2017

J Oral Diag

View full text Add to dashboard Cite

show abstract

“…Further studies of second cancers in CLL are needed to clarify the role of immunologic impairment and other determinants. When feasible, molecular probes could clarify the underlying mechanisms of tumors associated with CLL [10,12] . In our case the patient did not receive treatment for the CLL.…”

Section: Discumentioning

confidence: 99%

Unusual mandibular metastasis of bladder cancer in a patient and two synchronous malignancies, bladder cancer and chronic lymphocytic leukemia, in an inguinal lymph node: A case report

Liakou

Georgiou

Georgiadis

et al. 2015

CRCP

View full text Add to dashboard Cite

Metastatic lesions to the mandible are rare, comprising less than 1% of all malignancies. Breast, lung and colon cancer are the most common primary tumors with a mandibular mass as the initial presentation of metastatic disease. The following report describes an unusual case of a mandibular mass in a patient with recurrent bladder transitional cell carcinoma (TCC) with a past medical history of chronic lymphocytic leukemia (CLL), as well as the synchronous presence of both cancers during the evaluation of an inguinal enlarged lymph node. The sudden appearance of an isolated lesion in the head and neck region should always raise suspicion in a patient with a history of cancer that rarely metastasizes to this site. The co-existence of two malignancies in the same lymph node is extremely rare, and, to our knowledge, this is the first case of metastatic bladder cancer and CLL in the same lymph node.

show abstract

“…Our results indicate that TQ can down-regulate CXCR4 expression and CXCL12-induced migration and invasion in breast cancer cell lines through inhibition of NF-κB activation. Furthermore, we tried to investigate the effect of TQ on experimental metastasis that involved the injection of breast cancer cells directly into the systemic circulation (Hwang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis

et al. 2018

View full text Add to dashboard Cite

Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in patients with breast cancer. Therefore, new agents that can abrogate CXCR4 expression have potential against breast cancer metastasis. In this study, we examined the potential effect of thymoquinone (TQ), derived from the seeds of Nigella sativa, on the expression and regulation of CXCR4 in breast cancer cells. TQ was found to inhibit the expression of CXCR4 in MDA-MB-231 triple negative breast cancer (TNBC) cells in a dose- and time-dependent manner. It was noted that suppression of CXCR4 by TQ was possibly transcriptionally regulated, as treatment with this drug caused down-regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation and suppression of NF-κB binding to the CXCR4 promoter. Pretreatment with a proteasome inhibitor and/or lysosomal stabilization did not affect TQ induced suppression of CXCR4. Down-regulation of CXCR4 was further correlated with the inhibition of CXCL12-mediated migration and invasion of MDA-MB-231 cells. Interestingly, it was observed that the deletion of p65 could reverse the observed anti-invasive/anti-migratory effects of TQ in breast cancer cells. TQ also dose-dependently inhibited MDA-MB-231 tumor growth and tumor vascularity in a chick chorioallantoic membrane assay model. We also observed TQ (2 and 4 mg/kg) treatment significantly suppressed multiple lung, brain, and bone metastases in a dose-dependent manner in a metastasis breast cancer mouse model. Interestingly, H&E and immunohistochemical analysis of bone isolated from TQ treated mice indicated a reduction in number of osteolytic lesions and the expression of metastatic biomarkers. In conclusion, the results indicate that TQ primarily exerts its anti-metastatic effects by down-regulation of NF-κB regulated CXCR4 expression and thus has potential for the treatment of breast cancer.

show abstract

Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible

Cited by 6 publications

References 28 publications

Fine needle aspiration biopsy of mandible: an effective alternative to conventional biopsy for the differential diagnosis between metastasis and osteonecrosis in oncologic patients treated with bisphosphates - Case report

Fine needle aspiration biopsy of mandible: an effective alternative to conventional biopsy for the differential diagnosis between metastasis and osteonecrosis in oncologic patients treated with bisphosphates - Case report

Unusual mandibular metastasis of bladder cancer in a patient and two synchronous malignancies, bladder cancer and chronic lymphocytic leukemia, in an inguinal lymph node: A case report

Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis

Contact Info

Product

Resources

About