Diagnostic potential of Type VII Collagen during oral carcinogenesis

POOMSAWAT, Sopee; KARIYA, Abdulshukor; NIMMANON, Thirayost; KOSANWAT, Theerachai; JUENGSOMJIT, Rachai; Sirima, SANGUANSIN

doi:10.1590/1678-7757-2022-0486

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…This suggests a potential early role for altered stromal interactions in dysplastic development, possibly through reduced fibroblastic activity. Furthermore, studies have shown the reduced expression of type IV collagen (Col IV) and type VII collagen (Col VII) within the lamina densa of the basement membrane in oral leukoplakia with dysplasia ( 28 , 29 ), a phenomenon strongly associated with upregulated expression and activity of metalloproteinase 2 (MMP-2) and metalloproteinase 9 (MMP-9), suggesting their potential role in mediating basement membrane degradation ( 29 , 30 ), also related to reduced expression of TIMP metallopeptidase 1 (TIMP-1) ( 31 ). These observations suggest that dysplastic progression transcends the epithelial barrier, extending its molecular influence into the stroma through the basement membrane ( 32 ).…”

Section: Interaction Between Oral Dysplasia and Microenvironmentmentioning

confidence: 99%

New insights into the role of the oral leukoplakia microenvironment in malignant transformation

González-Arriagada,

Canedo-Marroquin,

Adorno-Farías

et al. 2024

Front. Oral. Health

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Oral leukoplakia is the most frequent and potentially malignant lesion of the oral cavity. Although dysplasia grading remains the main factor for risk assessment, challenges persist in determining the exact risk of transformation, and the literature has focused on studying alternative biomarkers. The interaction between dysplastic epithelial cells and the microenvironment starts early, and the communication is mainly mediated by lymphocytes, inflammatory factors, fibroblasts, and the extracellular matrix, leading to dysplastic progression. Leukoplakia-infiltrating leukocytes (LILs) and leukoplakia-associated fibroblasts (LAFs) play crucial roles in the dysplastic microenvironment. The immune response is related to intraepithelial T lymphocyte infiltration, mechanisms of immunosuppression coordinated by regulatory T cells, M2 macrophage polarization, and increased numbers of Langerhans cells; in contrast, fibroblastic and extracellular matrix factors are associated with increased numbers of pro-tumorigenic myofibroblasts, increased expression of metalloproteinases vs. decreased expression of TIMPs, and increased expression of chemokines and other inflammatory mediators. The microenvironment offers insights into the progression of leukoplakia to carcinoma, and understanding the complexity of the oral microenvironment in potentially malignant diseases aids in determining the risk of malignant transformation and proposing new therapeutic alternatives.

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