The new bone formation in human maxillary sinuses using two bone substitutes with different resorption types associated or not with autogenous bone graft: a comparative histomorphometric, immunohistochemical and randomized clinical study

Pereira, Rodrigo dos Santos; Bonardi, João Paulo; Ouverney, Felippe Ricardo Frossard; Campos, Annelise Backer; Griza, Geraldo Luiz; Okamoto, Roberta; Hochuli‐Vieira, Eduardo

doi:10.1590/1678-7757-2020-0568

Cited by 2 publications

(5 citation statements)

References 26 publications

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“…In total, 266 records did not meet the inclusion criteria based on titles and abstract were excluded. Upon full text assessment by two authors, 84 studies were selected for data extraction for qualitative analysis [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ...…”

Section: Resultsmentioning

confidence: 99%

Residual Bone Height and New Bone Formation after Maxillary Sinus Augmentation Procedure Using Biomaterials: A Network Meta-Analysis of Clinical Trials

et al. 2023

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Background. Different factors may affect new bone formation following maxillary sinus floor augmentation for the rehabilitation of posterior edentulous maxilla. The purpose of this study was to determine the influence of residual bone height (RBH) on new bone formation after lateral sinus augmentation utilizing different biomaterials, through a network meta-analysis (NMA). Methods. PUBMED, Scopus, and Web of Science electronic databases were searched until 31 December 2022 to obtain relevant articles. A hand search was also conducted. Randomised controlled studies on maxillary sinus augmentation comparing different grafting materials in patients with atrophic posterior maxilla, in need of prosthetic rehabilitation, were included. The risk of bias was assessed following the guidelines of the Cochrane Collaboration. The primary outcome was new bone formation (NBF), assessed histomorphometrically. The statistical analysis was performed by splitting the data according to RBH (<4 mm and ≥4 mm). Results. A total of 67 studies were eligible for conducting NMA. Overall, in the included studies, 1955 patients were treated and 2405 sinus augmentation procedures were performed. The biomaterials used were grouped into: autogenous bone (Auto), xenografts (XG), allografts (AG), alloplasts (AP), bioactive agents (Bio), hyaluronic acid (HA), and combinations of these. An inconsistency factor (IF) seen in the entire loop of the XG, AP, and Bio+AP was found to be statistically significant. The highest-ranked biomaterials for the <4 mm RBH outcome were XG+AG, XG+AP, and Auto. Similarly, the surface under the cumulative ranking curve (SUCRA) of biomaterials for ≥4 mm RBH was Auto, Bio+XG, and XG+Auto. Conclusion. There is no grafting biomaterial that is consistently performing better than others. The performance of the materials in terms of NBF may depend on the RBH. While choosing a biomaterial, practitioners should consider both patient-specific aspects and sinus clinical characteristics.

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Section: Resultsmentioning

confidence: 99%

Residual Bone Height and New Bone Formation after Maxillary Sinus Augmentation Procedure Using Biomaterials: A Network Meta-Analysis of Clinical Trials

et al. 2023

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“…When the HA was used for maxillary sinus bone graft, the outcomes demonstrated lower resorption as well as a lower mean of bone formation [ 13 , 23 , 24 ]. However, β-TCP has fast resorption with a suitable mean of bone formation compared with autogenous bone graft [ 11 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…The presence of connective tissue is a usual histological finding in areas of bone type IV, according to the Misch classification [ 1 ]. In addition, in those areas between connective tissue and new bone formation, osteoblasts can be observed in the bone matrix’s periphery in some cases [ 10 , 12 , 13 , 22 , 23 ]. These findings did not affect oral rehabilitation with dental implants in the present study or in other studies presented in the literature [ 10 , 12 , 13 , 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, in those areas between connective tissue and new bone formation, osteoblasts can be observed in the bone matrix’s periphery in some cases [ 10 , 12 , 13 , 22 , 23 ]. These findings did not affect oral rehabilitation with dental implants in the present study or in other studies presented in the literature [ 10 , 12 , 13 , 22 , 23 ]. It is possible to observe similar data in other clinical studies.…”

Section: Discussionmentioning

confidence: 99%

“…It is possible to observe similar data in other clinical studies. In an experimental study, Costa et al performed a comparison between BCP in granules and paste in rabbit maxillary sinuses [ 23 ]. After 10 weeks, their results stated 34.20% for granules and 23.28% for paste, which differs from the present research outcomes with 49.4% and 41.9% for granules and paste, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Assessment of Biphasic Calcium Phosphate in Granules and Paste Forms in Human Maxillary Sinus Bone Augmentation: A Randomized, Split-Mouth Clinical Trial

et al. 2023

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The aim of the present study is to compare the biphasic calcium phosphate (BCP) using two different forms—(1) granules and (2) paste—in human maxillary sinus bone reconstruction as a split-mouth study using histomorphometric and immunolabeling for osteocalcin. Ten patients with bilateral maxillary posterior partial edentulism were selected in order to reconstruct bone height. They were divided into two groups: BCPG and BCP-P. After six months of bone healing, biopsies were harvested to assess the new bone formation and immunostaining for osteocalcin. The BCP g group had the following results: mean of bone formation in pristine bone 49.4 ± 21.6%, intermediate 49.4 ± 16.2%, and apical 55.3 ± 21.4%. The group BCP-P had a mean of 41.9 ± 17.3% in the pristine bone region, 37.5 ± 7.8% for intermediate, and 39.0 ± 13.5% for apical. The osteocalcin immunolabeling was high for both groups, demonstrating bone calcification. Thus, the two biomaterials present suitable results for the placement of dental implants.

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The new bone formation in human maxillary sinuses using two bone substitutes with different resorption types associated or not with autogenous bone graft: a comparative histomorphometric, immunohistochemical and randomized clinical study

Cited by 2 publications

References 26 publications

Residual Bone Height and New Bone Formation after Maxillary Sinus Augmentation Procedure Using Biomaterials: A Network Meta-Analysis of Clinical Trials

Residual Bone Height and New Bone Formation after Maxillary Sinus Augmentation Procedure Using Biomaterials: A Network Meta-Analysis of Clinical Trials

Clinical Assessment of Biphasic Calcium Phosphate in Granules and Paste Forms in Human Maxillary Sinus Bone Augmentation: A Randomized, Split-Mouth Clinical Trial

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