miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis

Coêlho, Marina de Castro; Queiroz, Ingrid Costa; Filho, José Maria Chagas Viana; Aquino, Sabrina García de; Persuhn, Darlene Camati; Oliveira, Naila Francis Paulo de

doi:10.1590/1678-7757-2019-0583

Cited by 8 publications

(2 citation statements)

References 42 publications

(13 reference statements)

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“…Thus, the assessment of polymorphism in MTHFR has the potential to clarify the susceptibility to progressive periodontal tissue destruction. 11 In future studies, host susceptibility outcomes, such as MTHFR polymorphism, should be examined.…”

Section: Discussionmentioning

confidence: 99%

Mild elevation of C-reactive protein in a young patient with severe periodontitis: a case report with 2 years of follow-up

Hasuike

Nagao

Moriya³

et al. 2022

J Int Med Res

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Periodontal inflammation is associated with systemic disease. Low-grade inflammation (LGI) is critical to the link between periodontal disease and several systemic disorders. C-reactive protein (CRP) is a common circulating biomarker for acute-phase immune responses, and it is closely related to LGI. The present case demonstrated excellent results using a comprehensive approach for periodontitis in a young woman with severe periodontitis and mild CRP elevation. A 21-year-old Japanese woman complained of tooth mobility and bleeding during tooth brushing. She was pre-obese (body mass index = 29.9), and she had a mildly elevated CRP level (5.2 mg/L). Of all periodontal sites, 34.5% had deep pockets (≥6 mm). The patient was diagnosed with stage III, grade C periodontitis and generalized aggressive periodontitis. Comprehensive periodontal treatments, including regenerative procedures for vertical bone loss and furcation involvement, were performed. Periodontal tissue inflammation was resolved, and periodontal regeneration was achieved. During the 2-year follow-up period, her teeth did not exhibit any signs of instability, attachment loss, or bone loss. Despite the weak nature of the evidence, this case suggests that CRP is valuable for assessing LGI, and it may potentially be considered during periodontal grading in the future.

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Section: Discussionmentioning

confidence: 99%

Mild elevation of C-reactive protein in a young patient with severe periodontitis: a case report with 2 years of follow-up

Hasuike

Nagao

Moriya³

et al. 2022

J Int Med Res

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show abstract

“…Furthermore, methylation modifications include histone methylation, DNA methylation, and RNA methylation [51], which are dynamic processes regulated by methyltransferases and demethylases of histones, DNA, and RNA (Figure 2). These enzymes could control the fate of stem cells by mediating their pluripotency or differentiation [9,[52][53][54][55][56].…”

Section: Methylation Modifications Of Epigeneticsmentioning

confidence: 99%

Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells

Zhang

Fang

et al. 2022

Stem Cells International

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Dental mesenchymal stem cells (DMSCs) are crucial in tooth development and periodontal health, and their multipotential differentiation and self-renewal ability play a critical role in tissue engineering and regenerative medicine. Methylation modifications could promote the appropriate biological behavior by postsynthetic modification of DNA or protein and make the organism adapt to developmental and environmental prompts by regulating gene expression without changing the DNA sequence. Methylation modifications involved in DMSC fate include DNA methylation, RNA methylation, and histone modifications, which have been proven to exert a significant effect on the regulation of the fate of DMSCs, such as proliferation, self-renewal, and differentiation potential. Understanding the regulation of methylation modifications on the behavior and the immunoinflammatory responses involved in DMSCs contributes to further study of the mechanism of methylation on tissue regeneration and inflammation. In this review, we briefly summarize the key functions of histone methylation, RNA methylation, and DNA methylation in the differentiation potential and self-renewal of DMSCs as well as the opportunities and challenges for their application in tissue regeneration and disease therapy.

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The rosetta stone of successful ageing: does oral health have a role?

et al. 2023

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Ageing is an inevitable aspect of life and thus successful ageing is an important focus of recent scientific efforts. The biological process of ageing is mediated through the interaction of genes with environmental factors, increasing the body’s susceptibility to insults. Elucidating this process will increase our ability to prevent and treat age-related disease and consequently extend life expectancy. Notably, centenarians offer a unique perspective on the phenomenon of ageing. Current research highlights several age-associated alterations on the genetic, epigenetic and proteomic level. Consequently, nutrient sensing and mitochondrial function are altered, resulting in inflammation and exhaustion of regenerative ability.Oral health, an important contributor to overall health, remains underexplored in the context of extreme longevity. Good masticatory function ensures sufficient nutrient uptake, reducing morbidity and mortality in old age. The relationship between periodontal disease and systemic inflammatory pathologies is well established. Diabetes, rheumatoid arthritis and cardiovascular disease are among the most significant disease burdens influenced by inflammatory oral health conditions. Evidence suggests that the interaction is bi-directional, impacting progression, severity and mortality. Current models of ageing and longevity neglect an important factor in overall health and well-being, a gap that this review intends to illustrate and inspire avenues for future research.

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miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis

Cited by 8 publications

References 42 publications

Mild elevation of C-reactive protein in a young patient with severe periodontitis: a case report with 2 years of follow-up

Mild elevation of C-reactive protein in a young patient with severe periodontitis: a case report with 2 years of follow-up

Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells

The rosetta stone of successful ageing: does oral health have a role?

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