2020
DOI: 10.1590/1678-7757-2019-0558
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Abstract: Ameloblastoma cell lines derived from different subtypes demonstrate distinct developmental patterns in a novel animal experimental model Objective: Ameloblastoma is a representative odontogenic tumor comprising several characteristic invasive forms, and its pathophysiology has not been sufficiently elucidated. A stable animal experimental model using immortalized cell lines is crucial to explain the factors causing differences among the subtypes of ameloblastoma, but this model has not yet been disclosed. In … Show more

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Cited by 2 publications
(1 citation statement)
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“…Zhang et al [ 13 , 14 ] established an experimental model of ameloblastoma by transplanting ameloblastoma tissue and primary culture cells into immunodeficient mice. In addition, our research group transplanted immortalized ameloblastoma cells derived from follicular and plexiform types subcutaneously into the heads of immunodeficient mice and established stable animal experimental models of two different types of ameloblastoma [ 15 ]. By using such experimental animal models, we expect progress in the development of a novel therapeutic method for ameloblastoma.…”
Section: Introductionmentioning
confidence: 99%
“…Zhang et al [ 13 , 14 ] established an experimental model of ameloblastoma by transplanting ameloblastoma tissue and primary culture cells into immunodeficient mice. In addition, our research group transplanted immortalized ameloblastoma cells derived from follicular and plexiform types subcutaneously into the heads of immunodeficient mice and established stable animal experimental models of two different types of ameloblastoma [ 15 ]. By using such experimental animal models, we expect progress in the development of a novel therapeutic method for ameloblastoma.…”
Section: Introductionmentioning
confidence: 99%