Objectives:The main goal of this study was to investigate the effectiveness of SDF and its individual components, silver (Ag + ) and fluoride (F -) ions, in preventing enamel demineralization using biofilm and chemical models.Methodes: Polished human enamel specimens were assigned to five treatment groups (n=18 per group): SDF (38%); SDF followed by application of a saturated solution of potassium iodide (SDF+KI); silver nitrate (AgNO3; silver control, 253,900 ppm Ag + ); potassium fluoride (KF; fluoride control, 44,800 ppm