The effect of Maras powder and smoking on the microRNA deregulation of oral mucosa

Taş, Betül; Güre, Ali O.

doi:10.1590/1678-7757-2019-0382

Cited by 9 publications

(3 citation statements)

References 14 publications

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“…MO, Kahramanmaraş ve çevresindeki illerden Gaziantep, Şanlıurfa ve Elazığ yörelerinde de yaygın kullanılmakta olup bu bölgelerde de MO ile ilgili yayınlar yapılmaktadır. [31][32][33] Vaka sayımızın az olması çalışmamızın kısıtlılıklarından biridir. Öte yandan hastanemizde nikotinin aktif metaboliti olan ve santral etkilerinden sorumlu olan kotinin düzeyinin ölçülemiyor oluşu ve bunun klinik korelasyonunun yapılmamış olması ise çalışmamızın zayıf yönleri arasında sayılabilir.…”

Section: Discussionunclassified

Maraş Otu İntoksikasyonu İle Kliniğimize Başvuran Çocuk Olguların Değerlendirilmesi

Güneş

Sarişik

2020

Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi

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Amaç: Maraş otu (MO), tütün türlerinden olan Nicotina Rustica L. yaprakları ile meşe ve asma odunun küllerinden elde edilen, ağızda çiğnenerek kullanılan toz formunda kullanılan dumansız tütün ürünlerindendir. Bölgemizde halk arasında yaygın kullanımından dolayı çocuk vakaların erişimi kolay olmakta ve özellikle küçük yaş gruplarında ciddi intoksikasyon kliniği ile hastalar acilimize başvurmaktadırlar. Çalışmamızın amacı, acil servisimize MO' ya bağlı zehirlenme ile başvuran olguların değerlendirilmesi ve genel hatları ile bu ürünün hastalar üzerindeki etkilerinin araştırılmasıdır. Yöntem: Çalışmaya son 1 yıl içerisinde acil servisimize kazara MO yutmuş, yaşları 10 ay ile 3 yaş arasında değişen, 18 olgu dâhil edilmiştir. Hastalara ait demografik, klinik ve laboratuvar değerleri hasta dosyaları taranarak elde edilmiştir. Ek ilaç alımı olan vakalar dışlanmıştır. Veriler istatistik programına yüklenip değerlendirilmiştir. Bulgular: Çalışmaya alınan hastaların yaşları 20,5 (10-75) ay iken, bunların 10 tanesini erkek bireyler oluşturmaktaydı. Hastaların venöz kan gazı değerlerinde %33,3'ünde metabolik asidoz vardı; bu hastaların pH değerleri (7,26-7,38) iken HCO3 değerleri (16,12-20,90) mmol/L olarak değişmekteydi. Hastaların % 50'sinin laktik asit düzeyleri üst sınırlarda olup 1,9-6,10 mmol/L arasında değişmekteydi. Sonuç: MO, içerdiği yüksek nikotin oranından ve diğer maddelerden dolayı özellikle küçük yaş grubunda ciddi toksisitelere sebep olan maddelerden biri olması nedeniyle vakaların hızlıca değerlendirilip takibe alınması gerekmektedir. Anahtar kelimeler: Çocuk; dumansız tütün; Maraş otu; nikotin; zehirlenme. ABSTRACT Objective: Maras powder (MP) is a smokeless tobacco product obtained from Nicotina Rustica L., which is a type of tobacco, and the ashes of oak and grapevine, used in the form of a powder used in the mouth. Due to the widespread use among the population in our region, access to pediatric cases is easy and patients apply to our emergency department with a serious intoxication clinic especially in young age groups. The purpose of our study is to evaluate the patients who applied to our emergency department with MP-related poisoning and to investigate the general outlines and the effects of this product on patients. Materials and methods: The study included 18 cases, aged between 10 months and 3 years, who had accidentally swallowed MP to our emergency room in the past year. The demographic, clinical, and laboratory values of the patients were obtained by scanning patient files. Cases with additional drug intake are excluded. The data were uploaded to the statistical program and evaluated. Results: While the ages of the patients included in the study were 20.5 (10-75) months, 10 of them were male individuals. Metabolic acidosis was present in 33.3% of patients in venous blood gas values; while the pH values of these patients (7.26-7.38), HCO3 values (16.12-20.90) ranged from mmol / L. Lactic acid levels of 50% of the patients were at the upper limits and ranged between 1.9-6.10 mmol / L. Conclusion:...

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Section: Discussionunclassified

Maraş Otu İntoksikasyonu İle Kliniğimize Başvuran Çocuk Olguların Değerlendirilmesi

Güneş

Sarişik

2020

Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi

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“…Deregulation of micro RNAs mediate process of tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis, and invasion consequently leading to carcinogenesis. 25…”

Section: Genetic and Molecular Studies: Preclinical Studiesmentioning

confidence: 99%

Smokeless Tobacco and Its Ill-Effects: Recent Literature Update

Singhavi

Singh

Chaturvedi

2021

Indian J Med Paediatr Oncol

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According to the Global Adult Tobacco Survey part 2 (GATS-2), approximately 200 million adult Indians consume smokeless tobacco (SLT). Circumvention of SLT product ban has been observed. We conducted a review of the literature to summarize the ill effects of tobacco for the articles published from 2019 to 2020. A systematic search of the databases PubMed (2019 onward) and Web of Science (2019 onward), through February 2021 was done. Search yielded 1,061 articles and after excluding articles based on the inclusion criteria, 37 articles were taken in to consideration. The review shows that differential SLT product has specific odds of oral carcinogenesis. Review also indicates the emerging data of cardiovascular risk due to higher use of SLT products along with its known cause of oral cancer. It also cautions about the adverse consequences of pregnancy associated with SLT use.

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“…15 Another study reported that smoking has an effect on downregulation of miR-200b and miR-92a expressions on oral mucosa and there was a negative correlation between the number of cigarettes and the expression level of miR-203a. 16 Because of this knowledge, this study hypothesized that smoking can dysregulate miRNA expression profiles in periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

Six miRNA expressions in the saliva of smokers and non‐smokers with periodontal disease

Dede

Gökmenoğlu

Turkmen

et al. 2022

J of Periodontal Research

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Background It has been stated that microRNA (miRNA) plays an important role in development, homeostasis, and immune functions, and abnormal miRNA expression may cause faster disease progression. Objective The aim of this study was to determine miR‐203, miR‐142‐3p, miR‐146a, miR‐146b, miR‐155, and miR‐29b gene expressions in the saliva of smokers and non‐smokers with the periodontal disease before and after non‐surgical periodontal therapy (NSPT). Methods A total of 90 individuals, 30 with periodontitis, 30 with gingivitis, and 30 periodontally healthy (control group), were included. These three groups were divided into subgroups as smoking and non‐smoking individuals, with 15 people in each group. NSPT was applied to patients with periodontitis and gingivitis. Saliva samples and clinical parameters were obtained at baseline and repeated 6 weeks after NSPT. Results Saliva miR‐203, miR‐142‐3p, miR‐146a, miR‐146b, and miR‐155 gene expressions were significantly upregulated in patients with periodontal disease compared to the control group both in smokers and non‐smokers, and also these miRNAs' gene expressions were significantly higher in the periodontitis group than in the gingivitis group at baseline (p < .05). A significant increase in saliva miR‐142‐3p expression was detected in all groups of smokers compared to non‐smokers (p < .05). Although there was a decrease in salivary miRNAs gene expressions with the treatment, it was not statistically significant (p > .05). Conclusions These results suggest that salivary miR‐146a, miR‐146b, miR142‐3p, miR‐155, and miR‐203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment. Moreover, smoking may contribute to an increase in the levels of salivary miR‐142‐3p in the periodontal health and disease.

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The effect of Maras powder and smoking on the microRNA deregulation of oral mucosa

Cited by 9 publications

References 14 publications

Maraş Otu İntoksikasyonu İle Kliniğimize Başvuran Çocuk Olguların Değerlendirilmesi

Maraş Otu İntoksikasyonu İle Kliniğimize Başvuran Çocuk Olguların Değerlendirilmesi

Smokeless Tobacco and Its Ill-Effects: Recent Literature Update

Six miRNA expressions in the saliva of smokers and non‐smokers with periodontal disease

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