Development and characterization of a novel bulk-fill elastomeric temporary restorative composite

Abstract

Objectives:This study investigated the physical and mechanical properties, antibacterial effect and biocompatibility of novel elastomeric temporary resin-based filling materials (TFMs) containing zinc methacrylate (ZM).Material and Methods:Experimental TFMs were prepared by mixing the zinc methacrylate with monomer, co-monomer, photoinitiator and fillers. A ZM concentration of 0 (control), 0.5% (Z0.5); 1% (Z1), 2% (Z2), or 5% (ZM5) wt% was added to the TFMs. Fermit-N (F) was used for comparison with the experimental material. Microleakage, water sorption/solubility, degree of conversion, depth of cure, ultimate tensile strength, and hardness were determined and compared. A modified direct contact test (DCT) with Enterococcus faecalis and a Streptococcus mutans’ biofilm accumulation assay was carried out to evaluate the antimicrobial effect and cytotoxicity of the assay. Statistical comparisons were performed (α=5%).Results:The results showed that the physical and mechanical properties of the experimental TFMs with ZM are comparable with the properties of the commercial reference and some properties were improved, such as lower microleakage and water sorption, and higher ultimate tensile strength values. TFMs with ZM killed E. faecalis only after 1 h. Biofilm development of S. mutans was not affected by the inclusion of ZM in the experimental TFMs.Conclusions:The present findings suggest that the physical, mechanical and biological properties of the experimental TFMs with ZM are comparable with the properties of the commercial reference. However, some properties were improved, such as lower microleakage and water sorption, and higher ultimate tensile strength values.

Systematic Review of Zinc’s Benefits and Biological Effects on Oral Health

“…Finally, 33 studies were included for data extraction. Two articles were published in 2017 [27,28], ten in 2018 [12,13,[29][30][31][32][33][34][35][36], four in 2019 [37][38][39][40], seven in 2020 [41][42][43][44][45][46][47], nine in 2021 [48][49][50][51][52][53][54][55][56], and one in 2022 [57].…”

“…According to the quality assessment tool, 33 studies met the criteria and were considered reliable. The highest scores were 38/39 points in four studies [32,36,40,53] and 36/36 in three studies [13,48,55], while the lowest scores were 32/36 [27,28,47,51,52] and 34/39 [34,41] (Tables 3 and 4, and Supplementary Table S1, available online).…”

“…Considering the study design, five studies were in vivo [27,29,37,41,48] and 28 studies were in vitro [12,13,28,[30][31][32][33][34][35][36][38][39][40][42][43][44][45][46][47][49][50][51][52][53][54][55][56][57].…”

“…For the urinary system, the embryonic kidney cell line was used [49]; and for the hematopoietic system, red blood corpuscles [47], bone marrow mesenchymal stem cells [51], and umbilical vein endothelial cells [56] were applied. For the integumentary apparatus, fibroblast cells were used instead [32]; and for skeletal system, the osteosarcoma cell line [52] was used.…”

Inovações em resina composta: uma revisão de literatura

“…Isso pode ser justificado devido aos componentes que o óxido de difenil fosfina apresenta, Cadenaro et al (2010) relataram que fatores como hidrofilicidade e conteúdo de solvente dessas formulações desempenham um papel significativo no grau de conversão. Peralta et al (2019) investigaram os aspectos físicos e mecânicos, além propriedades antibacterianas e biocompatibilidade de novos compósitos Bulk Fill (BK) à base de componentes elastoméricos temporários contendo Metacrilato de Zinco (MZ). Com isso, foram observadas algumas propriedades melhoradas, como menor infiltração e maior sorção de água, além de aumento dos valores de resistência à tração final.…”