Lesions of the oral cavity of dogs: 720 cases

Blume, Guilherme Reis; Eloi, Rômulo Santos Adjuto; Oliveira, Letícia Batelli de; Sonne, Luciana; Rezende, Lucas P.O.

doi:10.1590/1678-5150-pvb-7073

Cited by 2 publications

(1 citation statement)

References 47 publications

(98 reference statements)

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“…Our study found a higher occurrence of OSCC in mixed breed dogs, although it was also present in various pure breeds, including Poodles, Labrador Retrievers, Beagles, Boxers, Border Collies, Siberian Huskies, Pekingese, Pinschers, and Yorkshire Terriers. Despite the limited sample size, the prevalence of oral cancers in mixed breeds has also been reported in other studies of dogs [14,40]. Contrary to what is generally reported in the literature [3], our study noted that OSCC affected purebred dogs of all sizes, from minor to medium and large.…”

Section: Discussionsupporting

confidence: 50%

Investigating Cox-2 and EGFR as Biomarkers in Canine Oral Squamous Cell Carcinoma: Implications for Diagnosis and Therapy

Files,

Santos,

Queiroga

et al. 2024

CIMB

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Oral squamous cell carcinoma (OSCC) is a common and highly aggressive dog tumor known for its local invasiveness and metastatic potential. Understanding the molecular mechanisms driving the development and progression of OSCC is crucial for improving diagnostic and therapeutic strategies. Additionally, spontaneous oral squamous cell carcinomas in dogs are an excellent model for studying human counterparts. In this study, we aimed to investigate the significance of two key molecular components, Cox-2 and EGFR, in canine OSCC. We examined 34 tumor sections from various dog breeds to assess the immunoexpression of Cox-2 and EGFR. Our findings revealed that Cox-2 was highly expressed in 70.6% of cases, while EGFR overexpression was observed in 44.1%. Cox-2 overexpression showed association with histological grade of malignancy (HGM) (p = 0.006) and EGFR with vascular invasion (p = 0.006). COX-2 and EGFR concurrent expression was associated with HGM (p = 0.002), as well as with the presence of vascular invasion (p = 0.002). These data suggest that Cox-2 and EGFR could be promising biomarkers and potential therapeutic targets, opening avenues for developing novel treatment strategies for dogs affected by OSCC. Further studies are warranted to delve deeper into these findings and translate them into clinical practice.

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Section: Discussionsupporting

confidence: 50%

Investigating Cox-2 and EGFR as Biomarkers in Canine Oral Squamous Cell Carcinoma: Implications for Diagnosis and Therapy

Files,

Santos,

Queiroga

et al. 2024

CIMB

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A retrospective study of lingual lesions in 793 dogs and 406 cats at the Athens Veterinary Diagnostic Laboratory, 2010–2020

Riker,

Rissi

2024

J VET Diagn Invest

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Lingual biopsies are a common type of sample submission at the Athens Veterinary Diagnostic Laboratory (AVDL). Here we describe the pathology diagnoses of 793 canine and 406 feline lingual biopsies submitted to the AVDL in a 10-y period. Non-neoplastic lesions accounted for 450 diagnoses (57%) in dogs and 239 diagnoses (59%) in cats. Canine non-neoplastic lesions consisted of inflammatory lesions (286 cases; 64% of non-neoplastic lesions) and tumor-like proliferative lesions (164 cases; 36% of non-neoplastic lesions). Feline non-neoplastic lesions consisted of inflammatory lesions (228 cases; 95% of non-neoplastic lesions) and tumor-like proliferative lesions (11 cases; 5% of non-neoplastic lesions). The most common canine neoplasms were melanocytic neoplasms (103 cases; 30% of neoplasms) and epithelial neoplasms (102 cases; 30% of neoplasms), followed by mesenchymal neoplasms (90 cases; 26% of neoplasms) and round cell neoplasms (48 cases; 14% of neoplasms). Approximately 43% of melanocytic neoplasms affected Chow Chows and Labrador Retrievers, and 20% of epithelial neoplasms affected Labrador Retrievers. In cats, most tumors were epithelial (158 cases; 94% of neoplasms), followed by mesenchymal (8 cases; 5% of neoplasms) and round cell neoplasms (1 case; 1% of neoplasms). Over 50% of neoplasms of cats affected domestic shorthair cats. Although the percentage of lingual biopsies that had a neoplastic diagnosis was roughly the same between species, the diversity of neoplasms was much greater in dogs than in cats.

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Lesions of the oral cavity of dogs: 720 cases

Cited by 2 publications

References 47 publications

Investigating Cox-2 and EGFR as Biomarkers in Canine Oral Squamous Cell Carcinoma: Implications for Diagnosis and Therapy

Investigating Cox-2 and EGFR as Biomarkers in Canine Oral Squamous Cell Carcinoma: Implications for Diagnosis and Therapy

A retrospective study of lingual lesions in 793 dogs and 406 cats at the Athens Veterinary Diagnostic Laboratory, 2010–2020

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