Cistatina C sérica em cães criticamente enfermos em UTI

Souza, Eliana Matias de; Arndt, Marcio H. L.; Gomes, M.G.; Val, Adriane P. Costa; Leme, Fabíola Oliveira Paes

doi:10.1590/1678-5150-pvb-5695

Cited by 2 publications

(4 citation statements)

References 63 publications

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“…CysC is efficient and early in the diagnosis of AKI compared to creatinine (Segev et al, 2016, Souza et al, 2018. The present study diagnosed kidney damage in nine (32.14%) animals in the first 24 hours after admission to the ICU, with eight (89%) showing ultrasound changes.…”

Section: Discussionmentioning

confidence: 60%

“…Early diagnosis of AKI favors implementing strategies to reduce the morbidity and mortality of affected patients; however, it still represents a challenge in veterinary medicine (Coca et al, 2008). Serum cystatin C (CysC) stands out for having the best correlation with the Glomerular Filtration Rate (GFR) (Miyagawa et al, 2021), being less influenced by extra-renal factors and for being earlier in comparison to serum creatinine, being considered an excellent early marker of AKI (Souza et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…CysC was measured 24, 48 and 72 hours after admission to the Veterinary Hospital using an immunoturbidimetric method (Cystatin C Turbiquest Plus-Labtest®) previously calibrated with purified canine CysC (BioVendor Research and Diagnostic products). The reference range used was 0.57mg/L to 1.2mg/L according to (Souza et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Correlation between renal ultrasonography and serum cystatin C in acute kidney disease of critically ill dogs

Souza

Muniz

Costa-Val

et al. 2022

Arq. Bras. Med. Vet. Zootec.

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Acute kidney injury (AKI) is defined as the rapid decline in kidney function. Its development is related to critical clinical statuses, such as sepsis, complicated post-surgical recovery, and infectious diseases. Serum cystatin C (CysC) has the best correlation with the glomerular filtration rate. Ultrasonography stands out because it is highly accessible and can be done at the bedside. Twenty-eight dogs admitted to the intensive care unit with serum creatinine values <1.6 mg/dL and at-risk factors of AKI development were selected. CysC measurements and ultrasound assessments were performed daily for 72 hours. Using CysC dosage, 22/28 animals (78.6%) were considered to have AKI, and 17/22 had ultrasound compatible with AKI changes, demonstrating moderate agreement with CysC dosage. Increased cortical renal echogenicity is the most prevalent alteration in critically ill patients and is correlated with serum increases in CysC and is associated with renal structural damage.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

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Correlation between renal ultrasonography and serum cystatin C in acute kidney disease of critically ill dogs

Souza

Muniz

Costa-Val

et al. 2022

Arq. Bras. Med. Vet. Zootec.

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“… * IRIS AKI based on historical, serum creatinine >1.6 mg/dl or increase of 0.3 mg/dl of serum creatinine within 48 h and/or a reduction in urinary output (<1 ml/kg/h) ou anuria over 6 h, ** ( 26 ) . …”

Section: Resultsmentioning

confidence: 99%

Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog

et al. 2021

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Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mild changes in creatinine serum levels or reduction of urine output that cannot be considered biomarkers of renal injury but failure or insufficiency. Twenty-eight dogs admitted to the Intensive Care Unit under risk factors for the development of AKI were evaluated. Blood samples were collected for determination of sCr and CysC at admission and after 24, 48, and 72 h. Urine output was measured by daily monitoring, measured by collection in a closed system. The results showed the incidence of AKI was 67.9% based on the IRIS criteria and 78.6% based on cystatin C in critically ill patients' dogs. The measurement of serum cystatin C immediately on admission to the ICU was superior in the early identification of patients with AKI when compared to the IRIS classification and serum creatinine in critically ill dogs.

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Cistatina C sérica em cães criticamente enfermos em UTI

Cited by 2 publications

References 63 publications

Correlation between renal ultrasonography and serum cystatin C in acute kidney disease of critically ill dogs

Correlation between renal ultrasonography and serum cystatin C in acute kidney disease of critically ill dogs

Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog

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