Abstract:XRN2 is an evolutionarily conserved 5’-to-3’ exoribonuclease, which degrades or trims various types of RNA in the nucleus. Although XRN-2 is essential for embryogenesis, larval development and reproduction in
Caenorhabditis elegans
, relevant molecular pathways remain unidentified. Here we create a germline-specific
xrn-2
conditional mutant and perform a mutagenesis screen for suppressors of sterility. Loss-of-function alleles of
dpy-10
,
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