miR-140-3p suppresses the proliferation and migration of macrophages

Qiao, Pingping; Jun, Zhu; Lu, Xiaoheng; Jin, Yifei; Wang, Yifan; Shan, Qianqian; Wang, Yaxian

doi:10.1590/1678-4685-gmb-2021-0160

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Biological activities of miR‐140 and miR‐200 in Schwann cells remain largely undetermined although an earlier study demonstrates that miR‐140 directly interacts with myelin transcription factor Egr2 (Krox‐20) and suppresses Schwann cell myelination (Viader et al, 2011). Actually, miR‐140 has been identified as a migration suppressor in many cell types, including macrophages, vascular smooth muscle cells, breast cancer cells, and hepatocellular carcinoma cells (Dou et al, 2021; Li et al, 2021; Ma et al, 2021; Qiao et al, 2022). By restraining the EMT process, miR‐140 hinders cell migration and invasion (Guo et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, (Viader et al, 2011). Actually, miR-140 has been identified as a migration suppressor in many cell types, including macrophages, vascular smooth muscle cells, breast cancer cells, and hepatocellular carcinoma cells (Dou et al, 2021;Li et al, 2021;Ma et al, 2021;Qiao et al, 2022). By restraining the EMT process, miR-140 hinders cell migration and invasion (Guo et al, 2020).…”

Section: Enhanced Migration Capacity Of Drg Schwann Cells Indicates Thatmentioning

confidence: 99%

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miR‐140 and miR‐200 regulate the migratory heterogeneity of location‐specific Schwann cell population

Chen

Miao

et al. 2023

Journal of Neurochemistry

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Schwann cells are functional cells in nerve regeneration and are commonly used as seed cells in tissue engineering. Enhanced Schwann cell migration capacity improves recovery effects, and thus, the identification of Schwann cells with greater migration ability is of great importance. In the present study, we examined the biological activities of Schwann cells collected from rat sciatic nerves (SN) and dorsal root ganglia (DRG). Observations from transwell migration assay and wound healing assay demonstrate that DRG Schwann cells migrate at a faster speed as compared with SN Schwann cells. Sequencing and bioinformatics suggest that differentially expressed genes between SN and DRG Schwann cells are associated with cell motility and migration. miR‐140 and miR‐200, two microRNAs (miRNAs) that are highly expressed in SN Schwann cells negatively influence Schwann cell migration and thus may be key regulators of Schwann cell phenotype. Igsf10, Plxna2, and Lcp1 are screened as candidate downstream targets of miR‐140 and miR‐200 based on bioinformatic analysis and their expression correlation with miRNAs. Our comparative analysis displays the unique characteristics of Schwann cells in different anatomical localizations and demonstrates that DRG Schwann cells are suitable seed cells for tissue engineering and regenerative medicine.image

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