Impact of maternal dietary counseling in the first year of life on DNA methylation in a cohort of children

Castilhos, Janaína Kehl de; Campagnolo, Paula Dal Bó; Almeida, Silvana; Vítolo, Márcia Regina; Mattevi, Vanessa Suñé

doi:10.1590/1678-4685-gmb-2020-0330

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…As a result, these factors may play a role in the rise in global DNA methylation. The findings of this study support the idea that nutritional interventions should be made early in life [ 749 ]. In another study, Anderson et al [ 750 ] found that maternal vitamin D supplementation affects the methylation of genes involved in developmental processes in mothers and breastfed babies.…”

Section: Breastfeeding and Epigeneticssupporting

confidence: 84%

“…The impact of dietary intervention in the first year of life on global methylation levels in leukocyte samples from a group of infants born in southern Brazil between 2001 and 2002 was investigated [ 749 ]. Overall methylation assessments were performed on DNA samples from 237 4-year-old children using enzyme-linked immunosorbent assays.…”

Section: Breastfeeding and Epigeneticsmentioning

confidence: 99%

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Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects

et al. 2022

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Infants who are exclusively breastfed in the first six months of age receive adequate nutrients, achieving optimal immune protection and growth. In addition to the known nutritional components of human breast milk (HBM), i.e., water, carbohydrates, fats and proteins, it is also a rich source of microRNAs, which impact epigenetic mechanisms. This comprehensive work presents an up-to-date overview of the immunomodulatory constituents of HBM, highlighting its content of circulating microRNAs. The epigenetic effects of HBM are discussed, especially those regulated by miRNAs. HBM contains more than 1400 microRNAs. The majority of these microRNAs originate from the lactating gland and are based on the remodeling of cells in the gland during breastfeeding. These miRNAs can affect epigenetic patterns by several mechanisms, including DNA methylation, histone modifications and RNA regulation, which could ultimately result in alterations in gene expressions. Therefore, the unique microRNA profile of HBM, including exosomal microRNAs, is implicated in the regulation of the genes responsible for a variety of immunological and physiological functions, such as FTO, INS, IGF1, NRF2, GLUT1 and FOXP3 genes. Hence, studying the HBM miRNA composition is important for improving the nutritional approaches for pregnancy and infant’s early life and preventing diseases that could occur in the future. Interestingly, the composition of miRNAs in HBM is affected by multiple factors, including diet, environmental and genetic factors.

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Section: Breastfeeding and Epigeneticssupporting

confidence: 84%

Section: Breastfeeding and Epigeneticsmentioning

confidence: 99%

Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects

et al. 2022

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Association of a Promoter DNA Methyltransferase 3 Gene Variant with DNA Methylation and Anthropometrics in Children from 4 to 12 Years Old

de Castilhos,

Campagnolo,

Almeida

et al. 2024

DNA

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The global prevalence of obesity among adults, adolescents, and children has increased to alarming levels, making this disease a serious public health problem. The etiology of obesity is complex and multifactorial. Currently, epigenetic alterations are being investigated to understand the mechanisms of interaction between genes and environmental and behavioral risk factors involved in the genesis of obesity. In this study, we examined the association of the DNA methyltransferase 3 (DNMT3B) gene-149 C>T variant (rs2424913) genotypes with global DNA methylation and the changes in anthropometric parameters in a cohort of 171 children followed from birth to 12 years old. Genotypes were obtained using real-time polymerase chain reaction, and global DNA methylation was measured in blood samples collected at 4 years old through enzyme-linked immunosorbent assays. Our results showed that the TT genotype is associated with an increase in global methylation levels at 4 years old and higher changes in body mass index, waist circumference, subscapular subcutaneous fat, body fat mass, body lean mass, and basal metabolic rate from 4 to 12 years. Our results suggest that this promoter DNMT3B gene variant and DNA methylation can be factors relevant to the increased risk of children developing obesity at an early age.

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Impact of maternal dietary counseling in the first year of life on DNA methylation in a cohort of children

Cited by 2 publications

References 33 publications

Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects

Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects

Association of a Promoter DNA Methyltransferase 3 Gene Variant with DNA Methylation and Anthropometrics in Children from 4 to 12 Years Old

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