2020
DOI: 10.1590/1678-4685-gmb-2019-0083
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PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts

Abstract: The XPC protein, which is mutated in xeroderma pigmentosum (XP) complementation group C (XP-C), is a lesion recognition factor in NER, but it has also been shown to interact with and stimulate DNA glycosylases, to act as transcriptional co-activator and on energy metabolism adaptation. We have previously demonstrated that XP-C cells show increased mitochondrial H 2 O 2 production with a shift between respiratory complexes I and II, leading to sensitivity to mitochondrial stress. Here we report a marked decreas… Show more

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Cited by 3 publications
(3 citation statements)
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“…The number and time of tumor formation were related to the degree of mtDNA consumption, and long-term depletion leads to the damage of mtDNA replication thus inducing the expression of early development and survival-promoting markers, including sonic hedgehog (SHH) [ 53 ]. PPARG related coactivator 1 (PPRC1), a transcription factor and regulator of mitochondrial biogenesis, may become a new therapeutic target for glioblastoma [ 54 , 55 ]. The above studies clarify the functions of these four genes in oxidative phosphorylation and the roles in tumors.…”
Section: Discussionmentioning
confidence: 99%
“…The number and time of tumor formation were related to the degree of mtDNA consumption, and long-term depletion leads to the damage of mtDNA replication thus inducing the expression of early development and survival-promoting markers, including sonic hedgehog (SHH) [ 53 ]. PPARG related coactivator 1 (PPRC1), a transcription factor and regulator of mitochondrial biogenesis, may become a new therapeutic target for glioblastoma [ 54 , 55 ]. The above studies clarify the functions of these four genes in oxidative phosphorylation and the roles in tumors.…”
Section: Discussionmentioning
confidence: 99%
“…Because activation of PGC-1α correlates with increased cellular energy demand [ 51 ], it is likely that ubiquinol protects RGCs via maintaining or increasing mtDNA in glaucomatous DBA/2J mice, in turn, leads to the preservation of PGC-1α expression. A previous study demonstrated that PGC-1α expression did not correlate with the expression level of TFAM [ 52 ] even though PGC-1α controls transcriptional expression of TFAM. Therefore, differential expression of PGC-1α and TFAM in glaucomatous retina suggests that ubiquinol may be associated with other transcriptional cofactors.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies have also shown that PGC-1β affects the growth and proliferation of tumor cells such as breast cancer, liver cancer, and glioma [10][11][12]. Comparatively few studies on PPRC1 have investigated the similar biological functions between PGC-1α and PGC-1β [13,14], while many have shown that PPRC1 not only plays an important role in improving and promoting oxidative stress, inflammation, and metabolic reprogramming but is also critical in regulating mitochondrial biogenesis and maintaining expression by coordinating the metabolic stress response [15]. It is well known that tumorigenesis is closely related to oxidative stress, metabolic reprogramming, and the regulation of mitochondrial energy metabolism.…”
Section: Introductionmentioning
confidence: 99%